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LILRB3

  • Official Full Name

    leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

  • Overview

    This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    LILRB3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; leukocyte immunoglobulin-like receptor subfamily B member 3; CD85a; HL9; ILT5; LIR 3; LIR3; CD85 antigen like family member A; CD85a antigen; IL T5; Immunoglobulin like transcript 5; Leukocyte immunoglobulin like receptor 3; Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 3; Leukocyte immunoglobulin like receptor subfamily B member 3; MGC138403; Monocyte inhibitory receptor HL9; PIRB; ILT-5; OTTHUMP00000069587; OTTHUMP00000197712; OTTHUMP00000237014; immunoglobulin-like transcript 5; CD85 antigen-like family member A; leukocyte immunoglobulin-like re; LIR-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Mammalian cells
  • Mouse
  • Yeast
  • Avi|Fc
  • C
  • His
  • Fc
  • Fc Chimera
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LILRB3-219H Active Recombinant Human LILRB3, Fc Chimera Mammalian cells Fc Chimera
Human LILRB3-522HB Active Recombinant Human LILRB3 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gly24-Glu443
Human LILRB3-0623H Recombinant Human LILRB3 protein, Fc & Avi-tagged, Biotinylated HEK293 Avi/Fc Gly 24 - Glu 443
Human LILRB3-7060H Recombinant Human LILRB3 protein, His-tagged E.coli His Leu217~Leu407
Human LILRB3-3356H Recombinant Human LILRB3 protein(Met1-Glu443), His-tagged HEK293 C-His Met1-Glu443
Human LILRB3-2208HCL Recombinant Human LILRB3 cell lysate Human Cell N/A
Human CAB11578MH Mouse Anti-Human Leukocyte immunoglobulin-like receptor subfamily B member 3 Monoclonal Antibody Mouse N/A
Human LILRB3-0372H Recombinant Human LILRB3 protein, Fc-tagged HEK293 Fc Gly24-Glu443
Human LILRB3-012H Recombinant Human LILRB3 Protein, His-tagged E.coli His
Human LILRB3-199H Recombinant Human LILRB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LILRB3-522H Recombinant Human LILRB3 protein, His-Avi-tagged HEK293 His-Avi Gly24-Glu443
Human LILRB3-3955H Recombinant Human LILRB3 Protein (Met1-Glu443), C-His tagged Mammalian cells C-His Met1-Glu443
Human LILRB3-357H Recombinant Human LILRB3 Protein, His-tagged HEK293 His Full
Human LILRB3-356H Recombinant Human LILRB3 Protein, Fc-tagged HEK293 Fc Full
Human LILRB3-362H Recombinant Human LILRB3 protein, Fc-tagged HEK293 human/IgG1/Fc 420
Human LILRB3-199H-B Recombinant Human LILRB3 Protein Pre-coupled Magnetic Beads HEK293
Human LILRB3-535H Recombinant Human LILRB3 Protein (Met1-Glu443), His-tagged, Biotinylated HEK293 His Met1-Glu443
Human CAB11579MH Mouse Anti-Human Leukocyte immunoglobulin-like receptor subfamily B member 3 Monoclonal Antibody Mouse N/A
Mouse LILRB3-908M Recombinant Mouse LILRB3 Protein, His-tagged HEK293 His
Mouse LILRB3-1653MCL Recombinant Mouse LILRB3 cell lysate Human Cell N/A
Mouse LILRB3-1445M Recombinant Mouse LILRB3 Protein (664-841 aa), His-tagged Yeast His 664-841 aa
Homo sapiens (Human) RFL29488HF Recombinant Full Length Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3(Lilrb3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-631)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LILRB3 Related Research Area

LILRB3 involved in several pathways and played different roles in them. We selected most pathways LILRB3 participated on our site, such as Adaptive Immune System, B cell receptor signaling pathway, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemGM11711;AP1S1;KIF11;SPTBN2;AP1M2;KIF2B;RNF6;TRIM69;CDKN1B
B cell receptor signaling pathwayACTR3;PRKCB;CD19;PIK3CD;PIK3R5;CMTM3;PLEKHA2;PPP3CC;PTPN6
Immune SystemSiglece;KIF2A;CLEC2D;GBP6;NA;MYO9B;IFI27;DYNC1H1;WSB1
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellCLEC2H;TREM1;CD200;MICA;ICAM4;AF251705;LAIR1;Siglece;TREML1
Osteoclast differentiationIFNB1;FOSL2;LILRA4;MAP3K14;PIK3R5;TGFBR2;SIRP-BETA;BLNK;MAPK13
Spinal Cord InjuryRGMA;GAP43;GDNF;OMG;LILRB3;KLK8;LGALS3;PTPRZ1;RTN4R

LILRB3 has several biochemical functions, for example, protein binding, receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB3 itself. We selected most functions LILRB3 had, and list some proteins which have the same functions with LILRB3. You can find most of the proteins on our site.

Function Related Protein
protein bindingTNFAIP8;NCL;MLF2;C22orf23;C15orf23;SLC30A1;THRA;TXNRD1;SVIP
receptor activityAGER;VMN1R50;KLRK1;FPR1;CSF2RB;MED17;PAQR4;ITGAX;SEC63
transmembrane signaling receptor activityFCAMR;ERBB2;LILRA1;BAI2;CD3D;CELSR1;NRXN3;KLRB1;CELSR3

LILRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB3.

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