lilrb3
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  • Official Full Name
  • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
  • Background
  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • LILRB3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; leukocyte immunoglobulin-like receptor subfamily B member 3; CD85a; HL9; ILT5; LIR 3; LIR3; CD85 antigen like family member A; CD85a antigen; IL T5; Immunoglobulin like transcript 5; Leukocyte immunoglobulin like receptor 3; Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 3; Leukocyte immunoglobulin like receptor subfamily B member 3; MGC138403; Monocyte inhibitory receptor HL9; PIRB; ILT-5; OTTHUMP00000069587; OTTHUMP00000197712; OTTHUMP00000237014; immunoglobulin-like transcript 5; CD85 antigen-like family member A; leukocyte immunoglobulin-like re; LIR-3
Cat.#:LILRB3-1445MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse LILRB3 Protein (664-841 aa), His-tagged
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Cat.#:LILRB3-362HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human LILRB3 Protein, Fc-tagged
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Cat.#:LILRB3-535HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LILRB3 Protein (Met1-Glu443), His-tagged, Biotinylated
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Cat.#:LILRB3-0623HTag:Fc/Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human LILRB3 protein, Fc & Avi-tagged, Biotinylated
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Cat.#:LILRB3-219HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human LILRB3, Fc Chimera
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Cat.#:LILRB3-3356HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LILRB3, His tagged
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Cat.#:LILRB3-7060HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LILRB3 protein, His-tagged
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Cat.#:LILRB3-908MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LILRB3 Protein, His-tagged
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Cat.#:LILRB3-2208HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LILRB3 cell lysate
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Cat.#:LILRB3-1653MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LILRB3 cell lysate
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Involved Pathway

LILRB3 involved in several pathways and played different roles in them. We selected most pathways LILRB3 participated on our site, such as Adaptive Immune System, B cell receptor signaling pathway, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with LILRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
KIF22; AGO3; AP1S3A; SPSB2; CLEC2H; GAN; AHCYL1; CDKN1B; MICA; KIR2DS2
B cell receptor signaling pathway
LILRB3; RAC3; CDK4; NFKB1; IKBKB; NFKBIB; INPPL1; MAPK4; ARPC4; PTPN6
Immune System
DHX9; NLRC5; SIGLEC15; CTS7; UFL1; KIF2B; SIGLEC12; CFHL4; SAMHD1; C1rb
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TREM1; MICA; AMICA1; CLEC2D; TREML1; KIR2DS2; SH2D1B; LILRB2; CD300LG; CD160
Osteoclast differentiation
ITGB3; SOCS3; PIK3R1; PIK3CD; FOSB; TGFBR1; OSCAR; MAP2K7; NFATC1; GAB2
Spinal Cord Injury
RTN4; NOX4; GAP43; GDNF; RTN4R; PTPRZ1; LILRB3; MBP; RGMA; AIF1

Protein Function

LILRB3 has several biochemical functions, for example, protein binding, receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LILRB3 itself. We selected most functions LILRB3 had, and list some proteins which have the same functions with LILRB3. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein RAB25; Itga10&Itgb1; MYO18A; CXCL2; EPHA4; KIF9; TNFRSF10A; FRS3; RHOT1; RHNO1
Function receptor activity
Related Protein MED30; GRIA2A; IGF2R; ITGB1A; GRIN1A; GRIA4B; SELS; NLGN4X; TNFRSF10B; SLC1A5
Function transmembrane signaling receptor activity
Related Protein CLDN3; CD3D; TLR2; EBP; GHRHRL; FZD8A; GABRQ; GLP1R; SLAMF1; GPR113

Interacting Protein

LILRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LILRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LILRB3.
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