LRPAP1
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Official Full Name
low density lipoprotein receptor-related protein associated protein 1
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Overview
LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II. -
Synonyms
LRPAP1; low density lipoprotein receptor-related protein associated protein 1; LRPAP1; RAP; MRAP; A2RAP; HBP44; A2MRAP; OTTHUMP00000115346; MGC138272; low density lipoprotein receptor-related protein associated protein 1; alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
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- GFP
- His
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- His (Fc)
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- His|Myc
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- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LRPAP1 Related Articles
- LRPAP1 Related Research Area
LRPAP1 involved in several pathways and played different roles in them. We selected most pathways LRPAP1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, Reelin signaling pathway, Signaling events mediated by the Hedgehog family, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Lissencephaly gene (LIS1) in neuronal migration and development | NDEL1;NUDC;DAB1;DCX;KATNA1;LRPAP1;DYNLT1;MAP1B;VLDLR |
Reelin signaling pathway | LRPAP1;MAP1B;DAB1;VLDLR |
Signaling events mediated by the Hedgehog family | LRPAP1;PTHLH |
LRPAP1 has several biochemical functions, for example, asialoglycoprotein receptor activity, heparin binding, lipase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPAP1 itself. We selected most functions LRPAP1 had, and list some proteins which have the same functions with LRPAP1. You can find most of the proteins on our site.
Function | Related Protein |
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asialoglycoprotein receptor activity | ASGR1;ASGR2;LRPAP1 |
heparin binding | KAL1;CTSG;F11;PRELP;CCL2;NRP2;APPB;BMP4;PLA2G5 |
lipase binding | PLIN5;APOB;LRPAP1;FAF2;GPIHBP1;APOA5 |
low-density lipoprotein particle receptor binding | APOE;APOEB;SYT1;ARRB2;SNX17;AP2M1;LANCL1;MMP13;DNAJA1 |
protein binding | ZC3H10;IQUB;DNAJB9;CLC;DUSP2;PLEKHO1;SLC3A1;LAMTOR1;DNAJB2 |
receptor antagonist activity | DKK1;ADH7;IL18BP;AGTR2;LRPAP1;ESR2 |
unfolded protein binding | APCS;CLN3;DNAJB1A;HSP90AA1.1;HSPA1A;ERLEC1;HSP90B1;LRPAP1;RUVBL2 |
very-low-density lipoprotein particle receptor binding | APOEA;LRPAP1;APOE;PCSK9;Reln;APOEB |
LRPAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPAP1.
VLDLR; LPL; LRP1; SMAD2; SORL1; PPM1G; RANBP2; POLA2; RTN4; ETV7; SUMO3; Lrp4; SORT1
- Q&As
- Reviews
Q&As (5)
Ask a questionLRPAP1 may be a potential therapeutic target in diseases where its interactions with LRP1 play a crucial role, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.
LRPAP1 has been implicated in immune system regulation, and its interactions with LRP1 may impact immune responses, suggesting potential applications in immunotherapy.
Genetic variations or mutations in the LRPAP1 gene have been investigated in the context of certain diseases, and understanding these variations may provide insights into disease susceptibility and progression.
LRPAP1 plays a role in lipoprotein metabolism by influencing the function of LRP1, a receptor involved in the clearance of lipoproteins from the circulation, thus impacting cardiovascular health.
Understanding the role of LRPAP1 in various diseases may contribute to personalized medicine by identifying individuals who could benefit from targeted therapies based on their specific genetic or molecular profiles.
Customer Reviews (3)
Write a reviewThis technical support is invaluable, especially for researchers who may be new to working with LRPAP1 protein or if they encounter specific difficulties while conducting their experiments.
They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.
the manufacturer's technical expertise can be advantageous to researchers.
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