lrpap1
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  • Official Full Name
  • low density lipoprotein receptor-related protein associated protein 1
  • Background
  • LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
  • Synonyms
  • LRPAP1; low density lipoprotein receptor-related protein associated protein 1; LRPAP1; RAP; MRAP; A2RAP; HBP44; A2MRAP; OTTHUMP00000115346; MGC138272; low density lipoprotein receptor-related protein associated protein 1; alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
Cat.#:LRPAP1-2017HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LRPAP1 Protein, His-tagged
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Cat.#:LRPAP1-4687HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LRPAP1 Protein, GST-tagged
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Cat.#:LRPAP1-848HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human LRPAP1 Protein, MYC/DDK-tagged
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Cat.#:LRPAP1-2264HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LRPAP1, His tagged
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Cat.#:LRPAP1-29430THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LRPAP1
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Cat.#:LRPAP1-75HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAP, FITC Labeled
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Cat.#:Lrpap1-113MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lrpap1, His-tagged
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Cat.#:Lrpap1-3359MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lrpap1, His tagged
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Cat.#:Lrpap1-184RTag:GST
Source (Host):Species:Rat
Product nameRecombinant rat Lrpap1, GST-Tagged
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Cat.#:LRPAP1-3456RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LRPAP1 Protein
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Cat.#:Lrpap1-7869RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lrpap1 protein, His-tagged
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Cat.#:LRPAP1-6619CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LRPAP1
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Cat.#:LRPAP1-11454ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LRPAP1
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Cat.#:LRPAP1-1384HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1, His-tagged
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Cat.#:LRPAP1-1251HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1
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Cat.#:Lrpap1-1252RTag:His/Myc
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Low Density Lipoprotein Receptor-Related Protein Associated Protein 1, His-tagged
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Cat.#:LRPAP1-2574HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LRPAP1 cell lysate
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Cat.#:LRPAP1-2168MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LRPAP1 cell lysate
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Involved Pathway

LRPAP1 involved in several pathways and played different roles in them. We selected most pathways LRPAP1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, Reelin signaling pathway, Signaling events mediated by the Hedgehog family, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Lissencephaly gene (LIS1) in neuronal migration and development
KATNA1; DYNLT1; DCX; LRPAP1; DAB1; NUDC; MAP1B; VLDLR; NDEL1
Reelin signaling pathway
VLDLR; LRPAP1; MAP1B; DAB1
Signaling events mediated by the Hedgehog family
LRPAP1; PTHLH

Protein Function

LRPAP1 has several biochemical functions, for example, asialoglycoprotein receptor activity, heparin binding, lipase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPAP1 itself. We selected most functions LRPAP1 had, and list some proteins which have the same functions with LRPAP1. You can find most of the proteins on our site.
Function
Related Protein
Function asialoglycoprotein receptor activity
Related Protein LRPAP1; ASGR1; ASGR2
Function heparin binding
Related Protein COL5A1; LIPI; ADAMTS8; PTPRF; COL25A1; NRP1; ADAMTS1; NELL2; ZFP207; PCOLCE
Function lipase binding
Related Protein GPIHBP1; LRPAP1; PLIN5; APOA5; APOB; FAF2
Function low-density lipoprotein particle receptor binding
Related Protein APOEB; MMP13; APOB; PCSK9; CCDC167; LRP2; HSP90B1; DNAJA1; SACS; DKK1
Function protein binding
Related Protein LDOC1; MAGEC2; USH1G; PARK2; C9orf142; KCTD1; ESYT1; SPANXC; Ar; TNF
Function receptor antagonist activity
Related Protein AGTR2; IL18BP; DKK1; ADH7; LRPAP1; ESR2
Function unfolded protein binding
Related Protein CALR; CCT3; DNAJB8; LRPAP1; NDUFAF1; SCG5; SRSF10; LMAN1; DNAJA2L; CALR3
Function very-low-density lipoprotein particle receptor binding
Related Protein APOEB; PCSK9; APOE; APOEA; LRPAP1; Reln

Interacting Protein

LRPAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPAP1.
VLDLR; LPL; LRP1; SMAD2; SORL1; PPM1G; RANBP2; POLA2; RTN4; ETV7; SUMO3; Lrp4; SORT1

LRPAP1 Related Articles

Fred, RG; Boddeti, SK; et al. Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells. CLINICAL SCIENCE 128:17-28(2015).
Singh, NK; Banerjee, BD; et al. APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease. NEUROLOGICAL SCIENCES 35:1075-1081(2014).