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LRPAP1

  • Official Full Name

    low density lipoprotein receptor-related protein associated protein 1

  • Overview

    LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
  • Synonyms

    LRPAP1; low density lipoprotein receptor-related protein associated protein 1; LRPAP1; RAP; MRAP; A2RAP; HBP44; A2MRAP; OTTHUMP00000115346; MGC138272; low density lipoprotein receptor-related protein associated protein 1; alpha-2-macroglobulin receptor-associated protein; alpha-2-MRAP; lipoprotein receptor associated protein; alpha-2-macroglobulin receptor-associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GFP
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • His|Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRPAP1-1251H Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 E.coli N/A
Human LRPAP1-1384H Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1, His-tagged E.coli His
Human LRPAP1-29430TH Recombinant Human LRPAP1 E.coli N/A
Human LRPAP1-75H Recombinant Human RAP, FITC Labeled E.coli N/A
Human LRPAP1-2264H Active Recombinant Human LRPAP1 protein, His-tagged HEK293 His Tyr35-Leu357
Human LRPAP1-2574HCL Recombinant Human LRPAP1 cell lysate Human Cell N/A
Human LRPAP1-848H Recombinant Human LRPAP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LRPAP1-6640H Recombinant Human LRPAP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LRPAP1-4687H Recombinant Human LRPAP1 Protein, GST-tagged Wheat Germ GST
Human LRPAP1-6026HF Recombinant Full Length Human LRPAP1 Protein, GST-tagged In Vitro Cell Free System GST 357 amino acids
Human LRPAP1-2017H Recombinant Human LRPAP1 Protein, His-tagged E.coli His Tyr35-Leu357
Human LRPAP1-4460H Recombinant Human LRPAP1 Protein (Tyr35-Leu357), N-His tagged E.coli N-His Tyr35-Leu357
Mouse Lrpap1-113M Recombinant Mouse Lrpap1, His-tagged E.coli His
Mouse Lrpap1-3359M Recombinant Mouse Lrpap1, His tagged Human Cell His
Mouse LRPAP1-2168MCL Recombinant Mouse LRPAP1 cell lysate Human Cell N/A
Mouse Lrpap1-7272M Recombinant Mouse Lrpap1 Protein, His-tagged E.coli His 29-360
Mouse Lrpap1-1340M Recombinant Mouse Lrpap1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Lrpap1-5912M Recombinant Mouse Lrpap1 protein, GFP-His-tagged HEK293 GFP-His 248-360aa(H294F,H296F,Y297C,H305F)
Mouse Lrpap1-1270M Recombinant Mouse Lrpap1 protein, His&Myc-tagged Insect Cell His&Myc 248-360aa
Mouse Lrpap1-5913M Recombinant Mouse Lrpap1 protein, His&Myc-tagged HEK293 His&Myc 248-360aa
Mouse Lrpap1-1271M Recombinant Mouse Lrpap1 protein, GFP-His-tagged Insect Cell GFP-His 248-360aa
Mouse Lrpap1-1108M Recombinant Mouse Lrpap1 protein E.coli N/A 248-360aa
Mouse Lrpap1-1274M Recombinant Mouse Lrpap1 protein, GFP-His-tagged Insect Cell GFP-His 248-360aa
Rat Lrpap1-184R Recombinant rat Lrpap1, GST-Tagged GST
Rat Lrpap1-1252R Recombinant Rat Low Density Lipoprotein Receptor-Related Protein Associated Protein 1, His-tagged E.coli His/Myc
Rat LRPAP1-3456R Recombinant Rat LRPAP1 Protein Mammalian Cell His
Rat Lrpap1-7869R Recombinant Rat Lrpap1 protein, His-tagged E.coli His Glu111~Leu360 (Accession # Q99068)
Rat LRPAP1-3112R Recombinant Rat LRPAP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LRPAP1-3112R-B Recombinant Rat LRPAP1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LRPAP1-11454Z Recombinant Zebrafish LRPAP1 Mammalian Cell His
Chicken LRPAP1-6619C Recombinant Chicken LRPAP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LRPAP1 Related Articles
  • LRPAP1 Related Research Area

LRPAP1 involved in several pathways and played different roles in them. We selected most pathways LRPAP1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, Reelin signaling pathway, Signaling events mediated by the Hedgehog family, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRPAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Lissencephaly gene (LIS1) in neuronal migration and developmentNDEL1;NUDC;DAB1;DCX;KATNA1;LRPAP1;DYNLT1;MAP1B;VLDLR
Reelin signaling pathwayLRPAP1;MAP1B;DAB1;VLDLR
Signaling events mediated by the Hedgehog familyLRPAP1;PTHLH

LRPAP1 has several biochemical functions, for example, asialoglycoprotein receptor activity, heparin binding, lipase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRPAP1 itself. We selected most functions LRPAP1 had, and list some proteins which have the same functions with LRPAP1. You can find most of the proteins on our site.

Function Related Protein
asialoglycoprotein receptor activityASGR1;ASGR2;LRPAP1
heparin bindingKAL1;CTSG;F11;PRELP;CCL2;NRP2;APPB;BMP4;PLA2G5
lipase bindingPLIN5;APOB;LRPAP1;FAF2;GPIHBP1;APOA5
low-density lipoprotein particle receptor bindingAPOE;APOEB;SYT1;ARRB2;SNX17;AP2M1;LANCL1;MMP13;DNAJA1
protein bindingZC3H10;IQUB;DNAJB9;CLC;DUSP2;PLEKHO1;SLC3A1;LAMTOR1;DNAJB2
receptor antagonist activityDKK1;ADH7;IL18BP;AGTR2;LRPAP1;ESR2
unfolded protein bindingAPCS;CLN3;DNAJB1A;HSP90AA1.1;HSPA1A;ERLEC1;HSP90B1;LRPAP1;RUVBL2
very-low-density lipoprotein particle receptor bindingAPOEA;LRPAP1;APOE;PCSK9;Reln;APOEB

LRPAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRPAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRPAP1.

VLDLR; LPL; LRP1; SMAD2; SORL1; PPM1G; RANBP2; POLA2; RTN4; ETV7; SUMO3; Lrp4; SORT1

Fred, RG; Boddeti, SK; et al. Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells. CLINICAL SCIENCE 128:17-28(2015).
Singh, NK; Banerjee, BD; et al. APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease. NEUROLOGICAL SCIENCES 35:1075-1081(2014).
  • Q&As
  • Reviews

Q&As (5)

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Can LRPAP1 be a target for therapeutic interventions, and if so, in what diseases? 11/29/2022

LRPAP1 may be a potential therapeutic target in diseases where its interactions with LRP1 play a crucial role, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.

In what ways does LRPAP1 influence the immune system, and how might this be relevant in clinical applications? 10/15/2021

LRPAP1 has been implicated in immune system regulation, and its interactions with LRP1 may impact immune responses, suggesting potential applications in immunotherapy.

Are there any known genetic variations or mutations in the LRPAP1 gene associated with diseases? 05/07/2020

Genetic variations or mutations in the LRPAP1 gene have been investigated in the context of certain diseases, and understanding these variations may provide insights into disease susceptibility and progression.

How does LRPAP1 contribute to the regulation of lipoprotein metabolism and cardiovascular health? 06/20/2016

LRPAP1 plays a role in lipoprotein metabolism by influencing the function of LRP1, a receptor involved in the clearance of lipoproteins from the circulation, thus impacting cardiovascular health.

How might the study of LRPAP1 contribute to personalized medicine approaches in the future? 02/14/2016

Understanding the role of LRPAP1 in various diseases may contribute to personalized medicine by identifying individuals who could benefit from targeted therapies based on their specific genetic or molecular profiles.

Customer Reviews (3)

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Reviews
12/17/2021

    This technical support is invaluable, especially for researchers who may be new to working with LRPAP1 protein or if they encounter specific difficulties while conducting their experiments.

    12/20/2020

      They can offer guidance on experimental design, protocol optimization, and troubleshooting, helping researchers overcome any challenges encountered during their trials.

      06/20/2016

        the manufacturer's technical expertise can be advantageous to researchers.

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