Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1, His-tagged

• Cat.No.: LRPAP1-1384H
• Product Overview: Recombinant humanLRPAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli andpurified by using conventional chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: LRPAP1,also known as alpha-2-macroglobulin receptor-associated protein, belongs tothe alpha-2-MRAP family. This protein interacts withLRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present onthe cell surface forming a complex with the alpha 2 macroglobulin receptorheavy and light chains In complex with the alpha 2 MR or gp330, it may havesome role in the pathogenesis of membrane glomerular nephritis.
• Form: Liquid. 20mM Tris-HClbuffer (pH8.0) containing 20% glycerol 1mM DTT.
• Molecular Weight: 40.4 kDa(348aa), confirmed by MALDI-TOF.
• Purity: > 90%by SDS - PAGE
• Concentration: 1.0mg/ml (determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMYSREK NQPKPSPKRE SGEEFRMEKL NQLWEKAQRLHLPPVRLAEL HADLKIQERD ELAWKKLKLD GLDEDGEKEARLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHHKEKVHEYNVLLETLSRTEEIHENVISPSDL SDIKGSVLHS RHTELKEKLR SINQGLDRLR RVSHQGYSTE AEFEEPRVID LWDLAQSANLTDKELEAFREELKHFEAKIEKHNHYQKQLE IAHEKLRHAE SVGDGERVSR SREKHALLEG RTKELGYTVK KHLQDLSGRI SRARHNEL
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: LRPAP1 low density lipoproteinreceptor-related protein associated protein 1 [ Homo sapiens ]
• Official Symbol: LRPAP1
• Synonyms: LRPAP1; low density lipoproteinreceptor-related protein associated protein 1; RAP; MRAP; A2RAP; HBP44;A2MRAP; MGC138272; alpha-2-macroglobulin receptor-associated protein;alpha-2-MRAP; OTTHUMP00000115346; lipoprotein receptor associated protein;alpha-2-macroglobulin receptor-associated protein 1; low density lipoproteinreceptor-related protein-associated protein 1; low densitylipoprotein-related protein-associated protein 1 (alpha-2-macroglobulinreceptor-associated protein 1)
• Gene ID: 4043
• mRNA Refseq: NM_002337
• Protein Refseq: NP_002328
• MIM: 104225
• UniProt ID: P30533
• Chromosome Location: 4p16.3
• Pathway: Lissencephaly gene (LIS1) in neuronalmigration and development; Reelin signaling pathway; Signaling eventsmediated by the Hedgehog family
• Function: asialoglycoprotein receptor activity;heparin binding; lipase binding; low-density lipoprotein particle receptorbinding; receptor antagonist activity; unfolded protein binding;very-low-density lipoprotein particle receptor binding