Recombinant Human Low Density Lipoprotein Receptor-Related Protein Associated Protein 1

• Cat.No.: LRPAP1-1251H
• Product Overview: Recombinant human LRPAP1 is expressed in E. coli.

Specification

• Cat. No.: LRPAP1-1251H
• Description: LRPAP1is a 39 kDa receptor-associated protein capable of universally inhibitingligand interaction with members of the LDL Receptor family that mediateendocytosis and signal transduction of many extracellular ligands whichparticipate in lipoprotein metabolism, protease regulation, embryonicdevelopment, and the pathogenesis of disease. It also binds tightly to gp330,an endocytic receptor that resembles LRP and is abundantly expressed in thekidney, and to the Very Low Density Lipoprotein (VLDL) Receptor. LRPAP1 promotesthe proper folding of these receptors, a function that is likely independentfrom its ability to inhibit ligand binding. Some evidence suggests LRPAP1 mayplay a role in regulating the expression of LRP, possibly by stabilizing thereceptor during biosynthesis or transport along the secretory pathway, andcould be a short-acting modulator of LRP activity.
• Source: E. coli
• Species: Human
• Form: Frozen Liquid in 0.1M Tris-HCl + 0.1 M NaCl pH 7.4.
• Concentration: 2.5 mg/mL
• Molecular Weight: 39 kDa
• Applications: Suitableto block receptor function in uptake assays.
• Storage: Store at-70°C. 3 years. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: LRPAP1

Gene Information

• Gene Name: LRPAP1low density lipoprotein receptor-related protein associated protein 1 [ Homosapiens ]
• Synonyms: LRPAP1; lowdensity lipoprotein receptor-related protein associated protein 1; RAP;MRAP; A2RAP; HBP44; A2MRAP; MGC138272; alpha-2-macroglobulinreceptor-associated protein; alpha-2-MRAP; OTTHUMP00000115346; OTTHUMP00000217120;alpha-2-macroglobulin receptor-associated protein 1; low-densitylipoprotein receptor-related protein associated protein 1; low-densitylipoprotein-related protein-associated protein 1 (alpha-2-macroglobulinreceptor-associated protein 1); lipoprotein receptor associated protein
• Gene ID: 4043
• mRNA Refseq: NM_002337
• Protein Refseq: NP_0023328
• MIM: 104225
• UniProt ID: P30533
• Chromosome Location: 4p16.3
• Pathway: Lissencephaly gene(LIS1) in neuronal migration and development; Reelin signaling pathway; Signalingevents mediated by the Hedgehog family
• Function: heparinbinding; lipase binding; unfolded protein binding; low-density lipoproteinparticle receptor binding; asialoglycoprotein receptor activity; receptorantagonist activity; very-low-density lipoprotein particle receptor binding