manf
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  • Official Full Name
  • mesencephalic astrocyte-derived neurotrophic factor
  • Background
  • The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
  • Synonyms
  • ARP; ARMET; MGC142148; MGC142150; mesencephalic astrocyte-derived neurotrophic factor; OTTHUMP00000210954; arginine-rich, mutated in early stage tumors
Cat.#:MANF-2015HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MANF Protein, His-tagged
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Cat.#:MANF-327HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MANF Protein, MYC/DDK-tagged
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Cat.#:MANF-522HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MANF Protein, His-tagged
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Cat.#:MANF-702HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human MANF Protein
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Cat.#:Manf-187MTag:N/A
Source (Host):E.coliSpecies:Mouse
Product nameRecombinant Mouse Manf protein
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Cat.#:Manf-928RTag:N/A
Source (Host):E.coliSpecies:Rat
Product nameRecombinant Rat Manf protein
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Cat.#:ARMET-837HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARMET protein
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Cat.#:ARMET-838HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARMET protein, GST-tagged
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Cat.#:MANF-13HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MANF, Carrier Free
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Cat.#:MANF-192HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MANF protein
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Cat.#:MANF-3205HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MANF, His tagged
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Cat.#:MANF-429HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MANF, His-tagged
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Cat.#:MANF-518HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human MANF protein, His-tagged
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Cat.#:MANF-536HTag:N/A
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human MANF protein
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Cat.#:MANF-639HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human MANF, His-tagged, Biotinylated
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Cat.#:MANF-693HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MANF Protein, Fc-tagged
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Cat.#:MANF-935MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MANF Protein, His-tagged
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Cat.#:MANF-4519ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MANF
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Cat.#:MANF-2212HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MANF cell lysate
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Cat.#:MANF-1581MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MANF cell lysate
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Protein Function

MANF has several biochemical functions, for example, growth factor activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MANF itself. We selected most functions MANF had, and list some proteins which have the same functions with MANF. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein NRG4; NUDT6; FGF8; FGF6; FGF13B; CLEC11A; NTF4; PDGFAB; KLK1B3; COL20A1
Function poly(A) RNA binding
Related Protein FSCN1; ETF1B; SCG3; NKRF; PDAP1; CSNK1E; TUFM; C3orf26; ACAA2; HNRNPA0

Interacting Protein

MANF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MANF here. Most of them are supplied by our site. Hope this information will be useful for your research of MANF.
IKBKE; ZDHHC17; Racgap1

MANF Related Gene Family

Cytokines