Recombinant Human MANF protein

• Cat.No.: MANF-192H
• Product Overview: Recombinant Human MANF was expressed in E. coli.

Specification

• Description: MANF is a neurotrophic factor found mainly in central nervous tissues where it may remain localized to the endoplasmic reticulum/Golgi apparatus, or secreted. It has been shown that MANF plays an important role in protecting cells against tunicamycin and thapsigargin -induced cell death. Without MANF, cells become increasingly vulnerable to the aforementioned drugs. Also, MANF is structurally homologous to CDNF.
• Source: E. coli
• Species: Human
• Form: Lyophilized from a 0.2 μm filtered solution in PBS
• Molecular Mass: 18.4 kDa
• Endotoxin: <1.0 EU/μg of recombinant protein as determined by the LAL method.
• Purity: 95%
• Applications: Cell Assay
• Storage: The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade- 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
• Reconstitution: Reconstitute at 200 μg/mL in PBS

Gene Information

• Gene Name: MANF mesencephalic astrocyte-derived neurotrophic factor [ Homo sapiens ]
• Official Symbol: MANF
• Synonyms: MANF; mesencephalic astrocyte-derived neurotrophic factor; arginine rich, mutated in early stage tumors , ARMET; ARP; arginine-rich, mutated in early stage tumors; ARMET; MGC142148; MGC142150
• Gene ID: 7873
• mRNA Refseq: NM_006010
• Protein Refseq: NP_006001
• MIM: 601916
• UniProt ID: P55145
• Chromosome Location: 3p21.1
• Function: growth factor activity; molecular_function