MAP2K5 Protein, MAP2K5 mitogen-activated protein kinase kinase 5


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Official Full Name MAP2K5 mitogen-activated protein kinase kinase 5
Background Mitogen-activated protein kinase kinase 5 (MKK5) belongs to the serine/threonine protein kinase family and the MAPK subfamily (MAP2K, MKK or MEKs). MKK5 specifically phosphorylates erk5/MAPK7 within the kinase activation loop pThr-E-pTyr motif. After activation erk5 phosphorylates MKK5 on multiple phosphoserine residues. The MKK5/erk5 pathway may play an important role in prostate and breast cancer.
Synonyms MAP2K5; mitogen-activated protein kinase kinase 5; PRKMK5; dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAPKK5; MEK5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • Human
    • Insect Cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K5-001H Recombinant Human MAP2K5 Protein, GST-tagged Insect Cells GST
    Human MAP2K5-003H Recombinant Human MAP2K5 Protein, GST-tagged Wheat Germ GST
    Human MAP2K5-29560TH Recombinant Human MAP2K5 Wheat Germ N/A
    Human MAP2K5-4509HCL Recombinant Human MAP2K5 293 Cell Lysate HEK293 N/A
    Human MAP2K5-492H Recombinant Human Mitogen-Activated Protein Kinase kinase 5, His-tagged Human His
    Human MAP2K5-597H Recombinant Human MAP2K5 Mammalian Cell His
    Mouse MAP2K5-9502M Recombinant Mouse MAP2K5 Protein Mammalian Cell His
    Rat MAP2K5-3561R Recombinant Rat MAP2K5 Protein Mammalian Cell His
    Cynomolgus Monkey MAP2K5-676C Recombinant Cynomolgus MAP2K5 Protein, His-tagged Mammalian Cell His
    Chicken MAP2K5-5458C Recombinant Chicken MAP2K5 Mammalian Cell His
    Zebrafish MAP2K5-6382Z Recombinant Zebrafish MAP2K5 Mammalian Cell His

    MAP2K5 involved in several pathways and played different roles in them. We selected most pathways MAP2K5 participated on our site, such as MAPK signaling pathway, Gap junction, Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNA1H; FGF1B; MOS; CACNB4; PDGFAA; NRAS; MAP3K14; RPS6KA4; FGF6A; MAP2K2
    Gap junction DRD2B; GNA15.4; TUBA4A; ITPR1; GJD2; TUBA8; HRASB; CDK1; ADRB3A; PDGFA
    Neurotrophin signaling pathway BAD; PLCG2; PLCG1; NTRK3; NTF3; PDPK1; SH2B2; RPS6KA1; NGFRAP1; CALM2
    Oxytocin signaling pathway NFATC2; CALM2; NPR2; MAP2K1; PIK3CD; FOS; PTGS2; MYLK3; PPP3CC; CACNA2D2

    MAP2K5 has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K5 itself. We selected most functions MAP2K5 had, and list some proteins which have the same functions with MAP2K5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACTC1; MLH1; PRKG2; CSNK2A2; SPS2; CSF1RA; ABCB5; PET112L; IP6K1; NUBP2
    metal ion binding ACSM4; EXT1B; RASSF5; ITK; MT1HL1; MAP3K3; ME3; ZNF16; ADPRHL2; GTF2E1
    protein binding TACR1; MEI4; PLRG1; TMEM110; DPH1; SYNJ2; VAV3; NUDT4; LEF1; LRP2
    protein kinase activity CAMK1DA; JAK2A; CDK1; PRKCHA; STK26; TNNI3K; ERBB4A; PAK2; EGFRA; NEK2
    protein serine/threonine kinase activity VRK2; KSR2; PHKG1A; OBSCN; ACVR2AA; TLK2; LRRK2; NEK10; ADCK4; RPS6KA3A
    protein tyrosine kinase activity BMX; MAP2K5; EPHB4B; MAP2K3; NTRK2B; PTK2BB; IGF1RB; HCK; PTK2; FGFR1B

    MAP2K5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K5.


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