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Recombinant Human Mitogen-Activated Protein Kinase kinase 5, His-tagged

Cat.No. : MAP2K5-492H
Product Overview : Recombinant human MAP2K5 protein, was expressed as 6 his-tagged fusion protein by E. coli and purified by Ni-sepharose.
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Cat. No. : MAP2K5-492H
Description : The protein encoded by MAP2K5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MAP2K5 specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Source : Human
Host : E. coli
Expression Vector : PET28a
Form : The puri?ed protein was resolved in 1 M PBS (58 mM Na2HPO4,17 mM NaH2PO4, 68 mM NaCl, pH 8.) added with 300 mM Imidazole and 0.7% Sarcosyl, 15% glycerol.
Buffer : PBS based buffer
Sequence : 96-448 amino acids
Molecular Mass : 44 kDa
Storage : The protein is stored in PBS bu?er at -20°C. Repeated freeze-thaw cycles should be avoided.
Gene Name : MAP2K5 mitogen-activated protein kinase kinase 5 [ Homo sapiens ]
Official Symbol : MAP2K5
Synonyms : MAP2K5; mitogen-activated protein kinase kinase 5; MEK5; MAPKK5; PRKMK5; HsT17454; dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; OTTHUMP00000164363; MAP kinase kinase 5; MAP kinase kinase MEK5b; EC; MKK5
Gene ID : 5607
mRNA Refseq : NM_001206804
Protein Refseq : NP_001193733
MIM : 602520
UniProt ID : Q13163
Chromosome Location : 15q23
Pathway : EGFR1 Signaling Pathway; ErbB1 downstream signaling; Focal Adhesi; Gap junction; Insulin Signaling; Integrin-mediated cell adhesion; Integrin-mediated cell adhesion; MicroRNAs in cardiomyocyte hypertrophy; NGF signalling via TRKA from the plasma membrane; Neurotrophin signaling pathway; Signalling by NGF; Signalling to ERK5; Signalling to ERK5; Trk receptor signaling mediated by the MAPK pathway
Function : ATP binding; MAP kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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