Recombinant Human MAP2K5 Protein, GST-tagged

• Cat.No.: MAP2K5-001H
• Product Overview: Recombinant Human MAP2K5 Protein with a GST tag was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
• Form: Liquid
• Molecular Mass: 77.0 kDa
• Purity: 70%-90%
• Notes: Small volumes of MEK5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Storage Buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Warning: For Research Use Only. Not for use in diagnostic procedures.

Gene Information

• Gene Name: MAP2K5 mitogen-activated protein kinase kinase 5 [ Homo sapiens (human) ]
• Official Symbol: MAP2K5
• Synonyms: MAP2K5; MAPKK5; MKK5; PRKMK5; SAPKK5; SKK5; HsT17454; mitogen-activated protein kinase kinase 5; dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MEK 5; EC 2.7.12.2
• Gene ID: 5607
• mRNA Refseq: NM_145160
• Protein Refseq: NP_660143
• MIM: 602520
• UniProt ID: Q13163