MTNR1A
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Official Full Name
melatonin receptor 1A
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Overview
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. -
Synonyms
MTNR1A; melatonin receptor 1A; melatonin receptor type 1A; MEL 1A R; MEL-1A-R; Mel1a melatonin receptor; Mel1a receptor; MelR; MR; MT 1; MT1; MTNR 1A; MTR1A_HUMAN;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Cattle
- Chicken
- Goat
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster)
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|S
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MTNR1A Related Articles
- MTNR1A Related Gene Family
MTNR1A involved in several pathways and played different roles in them. We selected most pathways MTNR1A participated on our site, such as Neuroactive ligand-receptor interaction, Circadian entrainment, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTNR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neuroactive ligand-receptor interaction | CSH;THRAA;GRIA3B;HTR1A;APLNR;HTR5AL;NPY2R;CNR1;GRIN3B |
Circadian entrainment | GNG10;CALML5;MTNR1A;GRIN2A;GNAI2;KCNJ5;ADCYAP1R1;RASD1;MTNR1B |
MTNR1A has several biochemical functions, for example, hormone binding, melatonin receptor activity, organic cyclic compound binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTNR1A itself. We selected most functions MTNR1A had, and list some proteins which have the same functions with MTNR1A. You can find most of the proteins on our site.
Function | Related Protein |
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hormone binding | UCN2;TTR;NPR3;NPR1;AMHR2;MC5R;LRP2;MC1R;ADIPOR1B |
melatonin receptor activity | MTNR1BB;MTNR1A;MTNR1AA;MTNR1AL;GPR50;MTNR1BA;MTNR1C;MTNR1B |
organic cyclic compound binding | MTNR1A;SLC16A1 |
protein binding | IL33;LRP2BP;PDCD5;GRHL3;SFPQ;MAPK12;PPP2R1A;ARHGEF15;WDR20 |
MTNR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTNR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of MTNR1A.
RGS20; MTNR1B; PGRMC1; IRS4; VAPB; GNAI2; GNAI3; CNP; HSPA5; EEF1G; CALR; CANX; TMEM33; RAB10
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