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Recombinant Human MTNR1A protein, His-tagged

Cat.No. : MTNR1A-8164H
Product Overview : Recombinant Human MTNR1A aa. (Gly296~Val350) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Source : E. coli
Species : Human
Tag : His
Form : Freeze-dried powder
Molecular Mass : 13kDa as determined by SDS-PAGE reducing conditions
Protein length : Gly296~Val350
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >98%
Characteristic : The isoelectric point is 6.6.
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200ug/mL
Storage Buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Gene Name : MTNR1A melatonin receptor 1A [ Homo sapiens (human) ]
Official Symbol : MTNR1A
Synonyms : MT1; MEL-1A-R; mel1a receptor; melatonin receptor type 1A
Gene ID : 4543
mRNA Refseq : NM_005958.4
Protein Refseq : NP_005949.1
UniProt ID : P48039

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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