musk
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  • Official Full Name
  • muscle, skeletal, receptor tyrosine kinase
  • Background
  • This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
  • Synonyms
  • MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324
Cat.#:MUSK-2372HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MUSK Protein (24-495 aa), His-tagged
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Cat.#:MUSK-5457HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Muscle, Skeletal, Receptor Tyrosine Kinase, GST-tagged
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Cat.#:MUSK-5760HTag:GST/His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human MUSK Protein, GST/His-tagged
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Cat.#:MUSK-1288MTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse MUSK Protein, His-SUMO/MYC-tagged
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Cat.#:MUSK-364HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MUSK, GST-tagged, Active
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Cat.#:MUSK-105HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MUSK, GST-tagged
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Cat.#:MUSK-165HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MUSK protein, DDK/His-tagged
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Cat.#:MUSK-30261THTag:
Source (Host):Species:Human
Product nameRecombinant Human MUSK
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Cat.#:MUSK-530HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MUSK
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Cat.#:MUSK-959HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MUSK, His & GST tagged
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Cat.#:Musk-1182MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Musk protein, His-tagged
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Cat.#:MUSK-3825RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MUSK Protein
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Cat.#:MUSK-5684CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MUSK
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Cat.#:MUSK-1246ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MUSK
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Cat.#:MUSK-557HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MUSK, His-tagged
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Cat.#:MUSK-1434HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MUSK (Active), GST-tagged
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Involved Pathway

MUSK involved in several pathways and played different roles in them. We selected most pathways MUSK participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ECM proteoglycans
HAPLN1; SPARC; MUSK; MATN3; FMOD; BGNA; PTPRS; COL9A1; DAG1; ITGB3A
Extracellular matrix organization
COL5A3B; TRAPPC4; FN1B; HAPLN1; MMP8; COL19A1; LTBP4; PCOLCEA; FURINA; SERPINH1B

Protein Function

MUSK has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUSK itself. We selected most functions MUSK had, and list some proteins which have the same functions with MUSK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CHTF18; TWF2; GTF2F2A; ATP8A1; CSNK1G1; PAICS; NEK9; OXSR1A; VRK3; MAT1A
Function metal ion binding
Related Protein NOTCH1A; OSGEP; ZNF433; ZFP161; DYTN; ZBTB37; CSRP1A; ZNF397; SETDB1B; LNX2
Function protein binding
Related Protein DYNC1I2; SLC30A8; POC1A; FRS3; HADHB; UNC13A; VAC14; BEND7; NCF2; ITGB2
Function protein tyrosine kinase activity
Related Protein EPHA4A; FGFR3; NEK1; FER; IGF1RB; ERBB4; EPHB2; LYN; KDRL; ABL1
Function transmembrane receptor protein tyrosine kinase activity
Related Protein FGFR1B; INSRR; ALK; FLT4; NPTNB; CSF1RA; ROS1; ROR2; NTRK3; EPHA4A

Interacting Protein

MUSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUSK here. Most of them are supplied by our site. Hope this information will be useful for your research of MUSK.
HSP90AB1; HSP90AA1; FKBP5; CDC37; HSP90AB1; Chrnb1

MUSK Related Articles

Ha, JC; Richman, DP; et al. Myasthenia gravis and related disorders: Pathology and molecular pathogenesis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:651-657(2015).
Katarzyna, MZ; Belaya, K; et al. Collagen Q - A potential target for autoantibodies in myasthenia gravis. JOURNAL OF THE NEUROLOGICAL SCIENCES 348:241-244(2015).