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MUSK

  • Official Full Name

    muscle, skeletal, receptor tyrosine kinase

  • Overview

    This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
  • Synonyms

    MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • Yeast
  • DDK|His
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|SUMO|Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MUSK-1434H Active Recombinant Human MUSK, GST-tagged Sf9 Insect Cell GST 519 aa-end
Human MUSK-30261TH Recombinant Human MUSK N/A
Human MUSK-5457H Recombinant Human Muscle, Skeletal, Receptor Tyrosine Kinase, GST-tagged Insect Cell GST
Human MUSK-959H Recombinant Human MUSK protein(Arg433-Val783), His&GST-tagged Insect Cells N-His&GST Arg433-Val783
Human MUSK-105H Recombinant Human MUSK, GST-tagged Wheat Germ GST
Human MUSK-557H Recombinant Human MUSK, His-tagged Sf9 Insect Cell His
Human MUSK-364H Recombinant Human MUSK, GST-tagged, Active Sf9 Insect Cell GST
Human MUSK-165H Recombinant Human MUSK protein, DDK/His-tagged HEK293 DDK/His
Human MUSK-530H Recombinant Human MUSK Mammalian Cell His
Human MUSK-5760H Active Recombinant Human MUSK Protein, GST/His-tagged Insect Cell GST/His
Human MUSK-2372H Recombinant Human MUSK Protein (24-495 aa), His-tagged Yeast His 24-495 aa
Human MUSK-3255H Recombinant Human MUSK protein, GST-tagged E.coli GST 24-495aa
Human MUSK-3547H-B Recombinant Human MUSK Protein Pre-coupled Magnetic Beads HEK293
Human MUSK-3547H Recombinant Human MUSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MUSK-2466H Recombinant Human MUSK Protein, His-tagged E.coli N-His Leu24-Thr495
Mouse MUSK-1288M Recombinant Mouse MUSK Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
Mouse Musk-1182M Recombinant Mouse Musk protein, His-tagged E.coli His Cys517~Arg777 (Accession # Q61006)
Rat MUSK-3825R Recombinant Rat MUSK Protein Mammalian Cell His
Rat MUSK-3484R-B Recombinant Rat MUSK Protein Pre-coupled Magnetic Beads HEK293
Rat MUSK-3484R Recombinant Rat MUSK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MUSK-1246Z Recombinant Zebrafish MUSK Mammalian Cell His
Chicken MUSK-5684C Recombinant Chicken MUSK Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MUSK Related Articles
  • MUSK Related Research Area

MUSK involved in several pathways and played different roles in them. We selected most pathways MUSK participated on our site, such as ECM proteoglycans, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUSK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM proteoglycansBGNA;VCANB;DAG1;ASPN;LRP4;SPARC;MATN3B;PTPRS;BGNB
Extracellular matrix organizationITGB3A;FAM49BA;PTPRS;LOXL2;CTSG;TLDC2;MMP11;TRAPPC4;LAMC3

MUSK has several biochemical functions, for example, ATP binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUSK itself. We selected most functions MUSK had, and list some proteins which have the same functions with MUSK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTRIB3;MAP3K11;DDX10;ABCA6;SMYHC2;KIF11;EPHA4;ATPBD4;PFKFB2
metal ion bindingZFP667;DRL;AMHR2;MICALL2B;PLA2G12B;ZBED5;REST;CTH1;CACNA1H
protein bindingPCNA;FCN1;RANBP6;PPP2R1B;DOCK10;ENTPD5;SALL4;ANKRA2;ESR2
protein tyrosine kinase activityCAMKK2;MAP2K3;LCK;AXL;MAP2K5;ZAP70;FGFR1;RET;KITA
transmembrane receptor protein tyrosine kinase activityRET;ERBB4A;CSF1RA;ROR2;ROS1;INSRR;EGFR;EPHA4A;TEK

MUSK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUSK here. Most of them are supplied by our site. Hope this information will be useful for your research of MUSK.

HSP90AB1; HSP90AA1; FKBP5; CDC37; HSP90AB1; Chrnb1

Ha, JC; Richman, DP; et al. Myasthenia gravis and related disorders: Pathology and molecular pathogenesis. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:651-657(2015).
Katarzyna, MZ; Belaya, K; et al. Collagen Q - A potential target for autoantibodies in myasthenia gravis. JOURNAL OF THE NEUROLOGICAL SCIENCES 348:241-244(2015).
  • Q&As
  • Reviews

Q&As (5)

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How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis? 02/19/2019

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life? 02/27/2018

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders? 07/10/2017

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration? 01/31/2017

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy? 08/19/2016

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.

Customer Reviews (3)

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Reviews
11/20/2022

    The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

    09/01/2017

      Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

      01/25/2017

        Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

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