Recombinant Human MUSK protein(Arg433-Val783), His&GST-tagged

• Cat.No.: MUSK-959H
• Product Overview: Recombinant Human MUSK isoform 2 (O15146-2) (Arg 433-Val 783) was expressed in Insect Cells, fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Specification

• Source: Insect Cells
• Species: Human
• Tag: His&GST
• Protein length: Arg433-Val783
• Form: Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10mM GSH.
• Molecular Mass: The recombinant human MUSK (aa 433-783)/GST chimera consists of 588 amino acids and has a calculated molecular mass of 68 kDa. It migrates as an approximately 58 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: Please refer to the hard copy of CoA.

Gene Information

• Gene Name: MUSK muscle, skeletal, receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: MUSK
• Synonyms: MUSK; muscle, skeletal, receptor tyrosine kinase; muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; MGC126323; MGC126324
• Gene ID: 4593
• mRNA Refseq: NM_001166280
• Protein Refseq: NP_001159752
• MIM: 601296
• UniProt ID: O15146

Reviews

11/20/2022

The MUSK protein's high quality, stellar technical support, and compatibility with diverse experimental approaches make it an optimal choice for meeting my research needs.

09/01/2017

Its usage in these techniques is highly praised by scientists worldwide, attesting to its effectiveness and significance in advancing scientific knowledge and understanding.

01/25/2017

Its ability to consistently provide accurate and reliable results makes it an invaluable tool for quantifying and detecting specific targets in biological samples.

Q&As

How is MUSK protein targeted in the treatment of autoimmune myasthenia gravis?

In autoimmune myasthenia gravis, immunosuppressive therapies and acetylcholinesterase inhibitors are commonly used to manage symptoms, and some treatments specifically target the immune response against MUSK.

Can MUSK protein abnormalities be detected early in life?

Yes, genetic testing and other diagnostic measures can identify MUSK protein abnormalities early in life, enabling prompt intervention and management.

Are there diagnostic tests for MUSK-related disorders?

Yes, diagnostic tests such as genetic testing and antibody assays can be employed to identify MUSK-related disorders.

How does MUSK protein contribute to muscle regeneration?

MUSK protein plays a role in signaling pathways that contribute to muscle regeneration, making it an important factor in tissue repair.

Can MUSK protein be a target for gene therapy?

Yes, gene therapy approaches aimed at restoring normal MUSK function are being explored as potential treatments for MUSK-related disorders.