NOS2 Protein, nitric oxide synthase 2, inducible

NOS2

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NOS2

Official Full Name nitric oxide synthase 2, inducible
Background Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms NOS2; nitric oxide synthase 2, inducible; HEP-NOS; NOS; nitric oxide synthase 2A (inducible, hepatocytes); Hepatocyte NOS; Inducible NO synthase; Peptidyl-cysteine S-nitrosylase NOS2; NOS type II; EC 1.14.13.39; INOS; nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS, type II; inducible NOS; OTTHUMP00000163279; NOS2A
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Nos2-65M Recombinant Mouse Nos2 Protein E.coli
    Human NOS2-298H Recombinant Human NOS2 Mammalian Cell His
    Human NOS2-3759HCL Recombinant Human NOS2 293 Cell Lysate HEK293 N/A
    Human NOS2-5992H Recombinant Human NOS2 Protein, GST-tagged Wheat Germ GST
    Human NOS2-611H Recombinant Human NOS2, His-Flag-tagged Insect Cell N/A
    Human NOS2-7795H Recombinant Human NOS2 protein, His & T7-tagged E.coli His/T7
    Human NOS2-7796H Recombinant Human NOS2 protein, His & T7-tagged E.coli His/T7
    Mouse NOS2-10786M Recombinant Mouse NOS2 Protein Mammalian Cell His
    Mouse Nos2-7797M Recombinant Mouse Nos2 protein, His-tagged E.coli His
    Mouse Nos2-7798M Recombinant Mouse Nos2 protein, His-tagged E.coli His
    Mouse Nos2-7799M Recombinant Mouse Nos2 protein, His-tagged E.coli His
    Rat NOS2-4024R Recombinant Rat NOS2 Protein Mammalian Cell His
    Rat Nos2-7800R Recombinant Rat Nos2 protein, His-tagged E.coli His
    Chicken NOS2-6520C Recombinant Chicken NOS2 Mammalian Cell His

    NOS2 involved in several pathways and played different roles in them. We selected most pathways NOS2 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arginine biosynthesis GLSA; GLUD2; GOT2; NOS2A; GLS2; GLS; GOT2A; ASL2; ybaS; ASL
    Arginine and proline metabolism MAOA; DAO.1; LAP3; ALDH7A1; CKBB; ODC1; AOC1; GOT2A; GOT1; ALDH3A2
    Metabolic pathways ALOX12; CRYL1; HPGDS; ATP6V1G2; ST3GAL2; HLCS; NADK2; MVDA; AGXT2L2; LSM1
    Calcium signaling pathway ERBB3B; ADCY1A; PLCZ1; PTK2BB; PLCD3; CD38; EDNRB; ADRB3; HTR2A; ATP2A2A
    HIF- signaling pathway EP300; NPPA; PIK3CA; INS; BCL2; TIMP1; IGF1; NFKB1; VHL; IGF1R
    Peroxisome ECH1; FAR1; PEX14; ACSL1B; HSD17B4; ACAA1A; PEX11C; PEX13; ACAA1; DAO.2
    Salmonella infection ACTB2; RHOG; LBP; MYD88; MAPK10; MYH10; CXCL8B.3; PFN1; CDC42L2; IFNGR1
    Pertussis IL6; NFKB1; TICAM2; CASP1; FOS; IL1A; RHOA; MAPK11; C4BP; CALML3
    Leishmaniasis FCGR2A; NOS2; HLA-DPB1; MAPK1; PTPN6; FCGR3B; TGFB2; HLA-DMB; HLA-DOB; FCGR1
    Chagas disease (American trypanosomiasis) IFNGR1; TRAF6; PIK3R1; PPP2R1B; LOC100033925; TICAM1; CD247; C1QB; TGFBR1; PIK3CD
    Toxoplasmosis STAT3; LAMB4; BAD; TGFB2; AKT1; IL12B; HLA-DOB; HSPA1A; PIK3R3; BIRC7
    Amoebiasis COL3A1; COL27A1; LAMB4; RAB7A; COL4A5; CXCL8; LAMB1; IL1R2; CXCL1; PIK3R1
    Tuberculosis IFNA2; ATP6V0C; MAPK3; ATP6V0D2; CLEC7A; TGFB2; HLA-DRB1; HLA-DOA; CALML3; IRAK4
    Pathways in cancer FGF20; FZD6; FGFR1; EGLN3; BID; CDC42; MMP9; FGF17; Fgf15; MLH1
    Small cell lung cancer LAMB1; LAMA1; BCL2; TP53; LAMB2; RARB; APAF1; NOS2; LAMA3; BIRC7

    NOS2 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS2 itself. We selected most functions NOS2 had, and list some proteins which have the same functions with NOS2. You can find most of the proteins on our site.

    Function Related Protein
    FMN binding POR; NOS3; NDOR1; NOS2; HAO2; DHODH; NOS1; PNPO; NOS2A; NOS2B
    NADP binding G6PDX; NOX5; PGD; CAT; NOX1; MTHFR; HMGCRA; POR; CRYM; ASPDH
    NADPH-hemoprotein reductase activity NOS2A; NOS2B; POR; NOS1; CYP2J6; NDOR1; MTRR; NOS3; NOS2
    arginine binding NAGS; RARS; NOS2; NOS3; NOS1
    calmodulin binding CAMK2B1; STRN; CAMKVB; MYH1E; MIP; C2orf62; CAMKK1; MYO1E; MYH9; PLCB1
    flavin adenine dinucleotide binding MTO1; DLD; KDM1A; PPOX; ACADVL; ACOX3; ACOX2; FMO3; GCDH; GCDHA
    heme binding CYP2R1; CYP2A4; DGCR8; PGRMC2; CYP2J5; CYBA; CYP3C1L2; CYP2K18; CYP4F3; CYP46A1.1
    iron ion binding CYP2X9; CYP26C1; CYGB; CYP2D9; CYP3A43; CYP2AA3; CYP46A1.1; XDH; OGFOD3; FAM84B
    nitric-oxide synthase activity NOS2A; NOS2; NOS1; NOS3; NOS2B
    protein binding IL1A; ABHD14B; GTF2H2; PSMC6; GOSR2; ABCG2; EZR; MAPK8IP3; UBE2O; FBN1
    protein homodimerization activity PTPRO; SHMT1; SRGAP2A; UGT1A7; ZBTB16; HOMER2; VIL1; XPNPEP1; NFKB1; CPOX
    receptor binding ARPP19; PVRL2L; PLA2G1B; FGF13B; CXCL1; HMGCL; SSTR3; PLG; FGF12A; FGF18B
    tetrahydrobiopterin binding TH; NOS2; NOS1; NOS3

    NOS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS2.

    GAPDH; S100A8; S100A9; arginine

    Niedbala, W; Besnard, AG; et al. Nitric oxide enhances Th9 cell differentiation and airway inflammation. NATURE COMMUNICATIONS 5:-(2014).
    Giordano, D; Draves, KE; et al. Nitric Oxide Regulates BAFF Expression and T Cell-Independent Antibody Responses. JOURNAL OF IMMUNOLOGY 193:1110-1120(2014).

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