nos2
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  • Official Full Name
  • nitric oxide synthase 2, inducible
  • Background
  • Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
  • Synonyms
  • NOS2; nitric oxide synthase 2, inducible; HEP-NOS; NOS; nitric oxide synthase 2A (inducible, hepatocytes); Hepatocyte NOS; Inducible NO synthase; Peptidyl-cysteine S-nitrosylase NOS2; NOS type II; EC 1.14.13.39; INOS; nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS, type II; inducible NOS; OTTHUMP00000163279; NOS2A
Cat.#:NOS2-5992HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOS2 Protein, GST-tagged
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Cat.#:NOS2-298HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NOS2
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Cat.#:NOS2-611HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NOS2, His-Flag-tagged
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Cat.#:NOS2-7795HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS2 protein, His & T7-tagged
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Cat.#:NOS2-7796HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS2 protein, His & T7-tagged
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Cat.#:NOS2-10786MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NOS2 Protein
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Cat.#:Nos2-7797MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:Nos2-7798MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:Nos2-7799MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:NOS2-4024RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NOS2 Protein
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Cat.#:Nos2-7800RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nos2 protein, His-tagged
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Cat.#:NOS2-6520CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NOS2
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Cat.#:NOS2-3759HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NOS2 293 Cell Lysate
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Involved Pathway

NOS2 involved in several pathways and played different roles in them. We selected most pathways NOS2 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
GOT1; GOT2; GLSA; GPT2; NAGS; GPT2L; GPT; NOS2; GLUD2; GOT2A
Arginine and proline metabolism
PRODH; GOT2B; Ckmm; ALDH2; SAT2; CKBB; AMD1; DAO.2; P4HA2; ALDH9A1A.1
Metabolic pathways
NDUFA4L2; UOX; PIGK; CYP27A1; NDUFS3; GALCB; ACER1; MAN2A2; PAPSS2; GCLM
Calcium signaling pathway
TMEM8C; CAMK2D1; PDE1C; PHKB; NOS1; ITPKC; PPP3R1B; PLN; ADRB2B; CHRM2
HIF- signaling pathway
LDHA; IFNGR1; TF; LTBR; NPPA; IFNG; CUL2; EIF4E2; HK2; FLT1
Peroxisome
DAO.2; CRAT; FAR1; ACSL4; NOS2B; IDH2; CAT; NOS2; ACSL4B; NUDT19
Salmonella infection
IFNG1-2; WASF1; TLR5; DYNC1I2A; NLRC4; MAPK8; PFN2; CASPA; IL8L1; FLNB
Pertussis
C4A; SERPING1; Hc; C1QA; ITGB2L; Itgam&Itgb2; IRF3; MAPK13; TNF; C4BPA
Leishmaniasis
MARCKSL1; MYD88; FOS; ELK1; STAT1; TRAF6; FCGR4; IL12B; MAPK11; HLA-DRB5
Chagas disease (American trypanosomiasis)
SMAD2; PPP2R1A; MYD88; GNA14; PIK3R2; ACE; CASP8; CXCL8; MAPK8; CCL5
Toxoplasmosis
HLA-DRA; CD40LG; IRGM; MAPK8; LAMA2; GNAI1; IL10RA; BIRC2; TLR2; BIRC3
Amoebiasis
AASS; Casp3; IL6; CD14; IL10; IL12B; SERPINB1B; PRKACG; PRKACB; SERPINB6
Tuberculosis
cgr2b; Ifna11; TGFB2; ARHGEF12; PPP3CB; IRAK4; RAB5B; NFKB1; CD209A; RAB7A
Pathways in cancer
MAPK3; NOS2; PTGER4; RXRG; VEGFB; HSP90AA1; LAMA3; ARHGEF1; FGFR3; FH
Small cell lung cancer
IKBKB; FHIT; CCND1; LAMA2; LAMA5; BIRC3; NFKBIA; AKT2; TP53; ITGA3

Protein Function

NOS2 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS2 itself. We selected most functions NOS2 had, and list some proteins which have the same functions with NOS2. You can find most of the proteins on our site.
Function
Related Protein
Function FMN binding
Related Protein CREG2; DHODH; POR; CREG1; NOS2; TYW1; NOS2A; NOS2B; TYW1B; HAO1
Function NADP binding
Related Protein HMGCRA; H6PD; FMO2; HMGCRB; NOS3; MTRR; IDH1; G6PD; POR; NOX5
Function NADPH-hemoprotein reductase activity
Related Protein MTRR; CYP2J6; NOS2; NOS3; NOS1; NOS2A; POR; NOS2B; NDOR1
Function arginine binding
Related Protein NOS3; NOS1; RARS; NAGS; NOS2
Function calmodulin binding
Related Protein SNTB1; SLC8A1; MYO5C; ITPKB; NRGNA; NOS1; STRN4; CAMK1G; MYH1E; PPP3CC
Function flavin adenine dinucleotide binding
Related Protein IVD; AIFM2; AOX1; D2HGDH; ACAD8; GCDHB; DLDH; CYBB; LDHD; AIFM4
Function heme binding
Related Protein CYGB1; CYP4A14; EIF2AK1; HRG-1; CYP2X7; HBA-X; CYP1D1; HBBE1.1; CYP2K18; HBB
Function iron ion binding
Related Protein ALKBH8; CYP2H1; CYP2E1; CYP2S1; CYP2AA1; CYP2D10; HBG1; CYP11A1; CYP8B3; CYP2V1
Function nitric-oxide synthase activity
Related Protein NOS2A; NOS1; NOS2B; NOS2; NOS3
Function protein binding
Related Protein NXF2; MYBL2; TPM4; KLRC2; CLK3; PECAM1; EGR1; KIF3A; LRRC33; CD74
Function protein homodimerization activity
Related Protein HMGCR; ACHE; CADM2; ENO3; Bcl2a1b; CD226; ENPP1; VEGFB; GOT2; TESCA
Function receptor binding
Related Protein NRXN1; INHA; PPP2R4; ICAM3; NOS2; NRG2B; DPP4; FLT3LG; Icosl; NRG1
Function tetrahydrobiopterin binding
Related Protein NOS1; TH; NOS2; NOS3

Interacting Protein

NOS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS2.
GAPDH; S100A8; S100A9; arginine

NOS2 Related Articles

Niedbala, W; Besnard, AG; et al. Nitric oxide enhances Th9 cell differentiation and airway inflammation. NATURE COMMUNICATIONS 5:-(2014).
Giordano, D; Draves, KE; et al. Nitric Oxide Regulates BAFF Expression and T Cell-Independent Antibody Responses. JOURNAL OF IMMUNOLOGY 193:1110-1120(2014).