nos2
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  • Official Full Name
  • nitric oxide synthase 2, inducible
  • Background
  • Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
  • Synonyms
  • NOS2; nitric oxide synthase 2, inducible; HEP-NOS; NOS; nitric oxide synthase 2A (inducible, hepatocytes); Hepatocyte NOS; Inducible NO synthase; Peptidyl-cysteine S-nitrosylase NOS2; NOS type II; EC 1.14.13.39; INOS; nitric oxide synthase, inducible; nitric oxide synthase, macrophage; NOS, type II; inducible NOS; OTTHUMP00000163279; NOS2A
Cat.#:NOS2-5992HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOS2 Protein, GST-tagged
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Cat.#:NOS2-298HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NOS2
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Cat.#:NOS2-611HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NOS2, His-Flag-tagged
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Cat.#:NOS2-7795HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS2 protein, His & T7-tagged
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Cat.#:NOS2-7796HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS2 protein, His & T7-tagged
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Cat.#:NOS2-10786MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NOS2 Protein
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Cat.#:Nos2-7797MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:Nos2-7798MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:Nos2-7799MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos2 protein, His-tagged
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Cat.#:NOS2-4024RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NOS2 Protein
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Cat.#:Nos2-7800RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nos2 protein, His-tagged
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Cat.#:NOS2-6520CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NOS2
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Cat.#:NOS2-3759HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NOS2 293 Cell Lysate
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Involved Pathway

NOS2 involved in several pathways and played different roles in them. We selected most pathways NOS2 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
ybaS; GLULC; GOT2A; GLUD1B; GPT2L; GLULA; ASS1; NOS2; NAGS; NOS2B
Arginine and proline metabolism
HOGA1; PYCRL; ADC; CARNS1; SAT1; P4HA1; LAP3; DAO.3; SMOX; DHDPSL
Metabolic pathways
IMPDH2; TST; POLA1; GBA; ALDH3A2A; PLA2G3; PDXP; ATP6V0E2; PLA2G10; EHHADH
Calcium signaling pathway
HTR2C; CALM1; CALML5; SLC8A1B; TNNC1B; GRIN2D; CACNA1C; EDNRAA; ATP2B2; CD38
HIF- signaling pathway
SERPINE1; PGK1; EIF4E2; IGF1; MAP2K2; MKNK1; ANGPT2; FLT1; BCL2; TFRC
Peroxisome
ACSL1A; ECH1; MLYCD; HACL1; PEX26; MPV17L2; IDH1; SLC25A17; ACSL3; NUDT7
Salmonella infection
RELA; RAB7B; WASB; CDC42; MAPK11; PFN1; FOS; KLC2; CXCL2; CXCL8B.3
Pertussis
C3; IRF3; ITGB2L; MYD88; MAPK11; Hc; Il23a; C4A; CD14; C1QB
Leishmaniasis
NCF2; IFNG; C3; HLA-DRA; MAPK13; ITGAM; IRAK1; HLA-DMB; FCGR4; ITGA4
Chagas disease (American trypanosomiasis)
PPP2R2B; GNAQ; CCL2; Fasl; IL1B; TLR4; AKT2; CD3D; PIK3R2; PIK3R3
Toxoplasmosis
TNF; IFNG; CASP8; HLA-DMA; IFNGR1; ALOX5; HSPA1B; XIAP; LAMA2; MAP2K6
Amoebiasis
SERPINB4; PIK3CD; RAB7B; SERPINB6B; IFNG; PRKCB; PIK3CB; LAMC1; COL4A3; IL-8
Tuberculosis
EEA1; IFNA14; ATP6V0B; RAB7A; HLA-DRB4; HLA-DMB; TNF; CAMK2G; HLA-DOA; TLR2
Pathways in cancer
MSH6; PTEN; ARNT; TRP53; BAX; NCOA4; MET; MAP2K1; ARHGEF12; FGF11
Small cell lung cancer
LAMA4; LAMC2; CCNE1; AKT1; IKBKG; BIRC2; ITGA2; LAMC1; PIK3CD; BIRC3

Protein Function

NOS2 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS2 itself. We selected most functions NOS2 had, and list some proteins which have the same functions with NOS2. You can find most of the proteins on our site.
Function
Related Protein
Function FMN binding
Related Protein POR; NOS3; CREG2; HAO2; NOS2B; NOS2A; HAO1; TYW1; NOS1; PNPO
Function NADP binding
Related Protein GSR; DHFRL1; NNT; HMGCRB; NDOR1; NOX1; CRYM; SPR; MTHFR; NOS1
Function NADPH-hemoprotein reductase activity
Related Protein NOS3; CYP2J6; NOS1; MTRR; POR; NOS2A; NOS2B; NDOR1; NOS2
Function arginine binding
Related Protein NOS3; RARS; NOS2; NOS1; NAGS
Function calmodulin binding
Related Protein IQCB1; MYH3; CAMKVB; MARCKSB; MKNK1; RRAD; ITPKB; AKAP5; MYH4; MAP2
Function flavin adenine dinucleotide binding
Related Protein NOX4; AIFM2; DUS3L; ETFA; ACADL; GFER; ACOX1; ACOXL; FMO2; AIFM3
Function heme binding
Related Protein CYP2C70; CYP4V7; PGRMC1; CYP46A1.2; TDO2; CYP2P10; CYGB; CYP2P6; MPX; CYP46A1.4
Function iron ion binding
Related Protein FAXDC2; CYP2K22; CYP2AA9; CYP17A2; CYP4Z1; CYP26C1; NOS2B; CALR; CYP2N13; FTH1
Function nitric-oxide synthase activity
Related Protein NOS2B; NOS3; NOS2A; NOS2; NOS1
Function protein binding
Related Protein DRG2; PXN; HMGB4; SVIL; ABCG2; TINAGL1; TGFB1I1; ALOX15; RAPGEF4; PTPRM
Function protein homodimerization activity
Related Protein OXCT1; RNF40; PDCD10; UGT1A2; PEX11B; SPATA24; CEBPE; RAB11FIP4B; GRPEL1; CRYBA2
Function receptor binding
Related Protein TRIM24; RARRES2; EDN3; CD2; NPY; TNFSF12; TYROBP; LHB; PGR; AMACR
Function tetrahydrobiopterin binding
Related Protein NOS1; TH; NOS3; NOS2

Interacting Protein

NOS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS2.
GAPDH; S100A8; S100A9; arginine

NOS2 Related Articles

Niedbala, W; Besnard, AG; et al. Nitric oxide enhances Th9 cell differentiation and airway inflammation. NATURE COMMUNICATIONS 5:-(2014).
Giordano, D; Draves, KE; et al. Nitric Oxide Regulates BAFF Expression and T Cell-Independent Antibody Responses. JOURNAL OF IMMUNOLOGY 193:1110-1120(2014).