Recombinant Human NOS2 Protein, GST-tagged

• Cat.No.: NOS2-5992H
• Product Overview: Human NOS2A partial ORF ( NP_000616, 685 a.a. - 794 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 37.84 kDa
• AA Sequence: DVRGKQHIQIPKLYTSNVTWDPHHY RLVQDSQPLDLSKALSSMHAKNVFT MRLKSRQNLQSPTSSRATILVELSC EDGQGLNYLPGEHLGVCPGNQPALV QGILERVVDG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: NOS2 nitric oxide synthase 2, inducible [ Homo sapiens ]
• Official Symbol: NOS2
• Synonyms: NOS2; nitric oxide synthase 2, inducible; nitric oxide synthase 2A (inducible, hepatocytes) , NOS2A; nitric oxide synthase, inducible; HEP NOS; iNOS; NOS; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes); INOS; NOS2A; HEP-NOS
• Gene ID: 4843
• mRNA Refseq: NM_000625
• Protein Refseq: NP_000616
• MIM: 163730
• UniProt ID: P35228

Reviews

12/18/2022

They can provide technical assistance, ensuring optimal utilization of the product.

11/09/2016

This unique capability to selectively bind to exposed PS simplifies the identification and quantification of different cellular populations, reducing experimental errors and enhancing accuracy.

02/02/2016

This may include providing detailed protocols, troubleshooting guidance, and access to knowledgeable experts who can answer any inquiries or concerns.

Q&As

How does genetic variation in the NOS2 gene impact clinical outcomes?

Genetic polymorphisms in the NOS2 gene have been associated with susceptibility to certain diseases and can influence individual response to treatment.

Are there any clinical biomarkers associated with NOS2 protein expression?

Certain inflammatory markers and nitric oxide levels can be associated with NOS2 protein expression in clinical settings.

How does NOS2 protein contribute to the pathogenesis of infectious diseases?

NOS2 protein plays a role in the host defense against pathogens by generating nitric oxide to inhibit microbial growth.

Can NOS2 protein be a potential therapeutic target in inflammatory diseases?

Can NOS2 protein expression be used to monitor response to treatment in clinical trials?

Monitoring changes in NOS2 protein expression may provide insights into treatment response and help evaluate therapeutic efficacy in clinical trials.