notch3
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  • Official Full Name
  • notch 3
  • Background
  • This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
  • Synonyms
  • NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;
Cat.#:NOTCH3-5999HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOTCH3 Protein, GST-tagged
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Cat.#:NOTCH3-2543HTag:Fc
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Notch Homolog 3 (Drosophila), Fc Chimera
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Cat.#:NOTCH3-1813HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOTCH3 protein, His & GST-tagged
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Cat.#:NOTCH3-29729THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NOTCH3
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Cat.#:Notch3-2544MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Notch Gene Homolog 3 (Drosophila) , Fc Chimera
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Cat.#:NOTCH3-4028RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NOTCH3 Protein
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Cat.#:NOTCH3-9094ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NOTCH3
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Cat.#:CSC-P0983Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0984Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0985Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 scFv Stable Cell Line-CHO
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Cat.#:CSC-P0989Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0990Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0991Tag:
Source (Host):Species:Human
Product nameAnti-Human NOTCH3 scFv Stable Cell Line-CHO
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Involved Pathway

NOTCH3 involved in several pathways and played different roles in them. We selected most pathways NOTCH3 participated on our site, such as Dorso-ventral axis formation, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dorso-ventral axis formation
ETV7; PIWIL1; NOTCH4; CPEB1B; CPEB1; ETS1; MAP2K1; NOTCH2; FMN2; KRAS
Notch signaling pathway
DTX3L; NOTCH1B; KAT2B; DLA; DNER; JAG1B; MIB1; HER6; PSENEN; DTX1
Thyroid hormone signaling pathway
NCOA1; SLC9A1; ATP1A2; MED30; NOTCH4; TBC1D4; NRAS; NOTCH2; HDAC2; NOTCH1
MicroRNAs in cancer
ZEB2; PDGFRB; MARCKS; TNR; MMP16; TP63; RASSF1; MTOR; THBS1; CDC25A

Protein Function

NOTCH3 has several biochemical functions, for example, calcium ion binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH3 itself. We selected most functions NOTCH3 had, and list some proteins which have the same functions with NOTCH3. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MMP1A; S100Z; CAPNS1A; PVALB3; ACTN2; LPCAT1; CDH23; VWCE; EFHC1; CRACR2B
Function enzyme binding
Related Protein PARP4; USP22; EGLN1; NPC2; PEX5; AKT1; CLSTN2; MSH3; HOXA9; WWOX
Function protein binding
Related Protein RPA2; DAPK1; RANBP3; AHNAK2; MPHOSPH6; Trf; AP1B1; DDX47; CYB561; SLIT2

Interacting Protein

NOTCH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH3.
Psma1; ABL1; NCK1; JAG1; LRP1; ANKRD28; FBLN1; CSNK2B; opuD; ald1; q8d176_yerpe; rhsA5; E2F3

NOTCH3 Related Articles

Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).