NOTCH3

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NOTCH3

Official Full Name notch 3
Background This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Synonyms NOTCH3; notch 3; IMF2; CASIL; CADASIL; neurogenic locus notch homolog protein 3; Notch homolog 3;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NOTCH3-1813H Recombinant Human NOTCH3 protein, His & GST-tagged E.coli His/GST
    Human NOTCH3-2543H Recombinant Human Notch Homolog 3 (Drosophila), Fc Chimera Sf21 Insect Cell Fc
    Human NOTCH3-29729TH Recombinant Human NOTCH3 Wheat Germ N/A
    Human NOTCH3-5999H Recombinant Human NOTCH3 Protein, GST-tagged Wheat Germ GST
    Mouse Notch3-2544M Recombinant Mouse Notch Gene Homolog 3 (Drosophila) , Fc Chimera Insect Cell Fc
    Rat NOTCH3-4028R Recombinant Rat NOTCH3 Protein Mammalian Cell His
    Zebrafish NOTCH3-9094Z Recombinant Zebrafish NOTCH3 Mammalian Cell His

    NOTCH3 involved in several pathways and played different roles in them. We selected most pathways NOTCH3 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dorso-ventral axis formation SPIRE1; MAP2K1; PIWIL1; NOTCH3; SPIRE2; GRB2B; MAPK3; CPEB1B; NOTCH1B; EGFRA
    Notch signaling pathway DTX3L; DLL4; DTX1; LFNG; NUMB; JAG1B; RFNG; DLK1; JAG1A; CTBP1
    Thyroid hormone signaling pathway BAD; SIN3A; NOTCH4; FXYD2; TP53; PLCG2; NOTCH2; RHEB; ATP1B3; PIK3CD
    MicroRNAs in cancer DICER1; RASSF1; ST14; DDIT4; CD44; TNR; DNMT1; TIMP3; GLS; RPTOR

    NOTCH3 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH3 itself. We selected most functions NOTCH3 had, and list some proteins which have the same functions with NOTCH3. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SLC25A23B; EFCAB3; DMP1; PLA2G2A; NUCB2A; PCDHGB3; CAPN1A; EFCAB1; CUBN; S100A9
    enzyme binding PTPLAD1; PRTN3; TTN; LYN; HDAC2; MAPT; SUPT5H; HMOX1; KDM1A; JUN
    protein binding LRRC4C; OAZ1; NAP1L1; CST1; COL10A1; FLOT2; HOXB6; LGALS8; RYR1; BIRC3

    NOTCH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH3.

    Psma1; ABL1; NCK1; JAG1; LRP1; ANKRD28; FBLN1; CSNK2B; opuD; ald1; q8d176_yerpe; rhsA5; E2F3

    Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
    Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).

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