nox4
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  • Official Full Name
  • NADPH oxidase 4
  • Background
  • This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • NOX4; NADPH oxidase 4; KOX; KOX 1; kidney oxidase-1; renal NAD(P)H-oxidase; kidney superoxide-producing NADPH oxidase; KOX-1; RENOX
Cat.#:NOX4-1475RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat NOX4 Protein (210-424 aa), His-tagged
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Cat.#:NOX4-2200RTag:His|B2M
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat NOX4 Protein (210-424 aa), His-B2M-tagged
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Cat.#:NOX4-6008HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOX4 Protein, GST-tagged
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Cat.#:NOX4-1336HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOX4, GST-tagged
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Cat.#:NOX4-1977HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOX4 protein, His-tagged
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Cat.#:NOX4-22HTag:N/A
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOX4 Protein
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Cat.#:NOX4-29711THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NOX4
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Cat.#:NOX4-4032RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NOX4 Protein
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Cat.#:NOX4-3740CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NOX4
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Involved Pathway

NOX4 involved in several pathways and played different roles in them. We selected most pathways NOX4 participated on our site, such as Oxidative Stress, Signaling events mediated by PTP1B, Spinal Cord Injury, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative Stress
NOX4; NQO1; JUNBA; TXN2; NFIX; TXNRD2
Signaling events mediated by PTP1B
CSN2; NOX4; YBX1; DOK1
Spinal Cord Injury
GAP43; MBP; AIF1; PTPRZ1; KLK8; TNFSF13B; RTN4; LILRB3; RGMA; NOX4

Protein Function

NOX4 has several biochemical functions, for example, NAD(P)H oxidase activity, electron carrier activity, flavin adenine dinucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOX4 itself. We selected most functions NOX4 had, and list some proteins which have the same functions with NOX4. You can find most of the proteins on our site.
Function
Related Protein
Function NAD(P)H oxidase activity
Related Protein AIFM1; DERL3; KMO; NOX4; CYB5R4; DUOX2
Function electron carrier activity
Related Protein TXNRD1; AIFM1; NDUFA12; NOX4; ALDH2; GPX2; AOX4; FDX1L; ACOX1; ACAD9
Function flavin adenine dinucleotide binding
Related Protein FMO3; TXNRD1; DUS3L; GFER; CRY-DASH; ACOXL; GSR; AOX1; AOX4; ETFDH
Function heme binding
Related Protein CYP3A7; CYP17A2; HBA2; PTGS1; CYP4F11; HBZ; SRC; CYP1D1; CYP2X10.2; CYP4T8
Function modified amino acid binding
Related Protein NOX4; CBS; MTHFR; CPS1; MUT; DPEP1
Function nucleotide binding
Related Protein ATP11A; RAD51L1; ATP1A1B; CELF2; UBE2D1A; EPHA2A; RDM1; TUBA8L3; CLK2A; PLK2B
Function oxygen sensor activity
Related Protein HIF1AN; EGLN2; NOX4
Function superoxide-generating NADPH oxidase activity
Related Protein SH3PXD2AA; PAX2; NOX3; NOX5; CYBB; NOX1; NCF1; NOX4

NOX4 Related Articles

Zhao, WW; Ma, GX; et al. Lipopolysaccharide induced LOX-1 expression via TLR4/MyD88/ROS activated p38MAPK-NF-kappa B pathway. VASCULAR PHARMACOLOGY 63:162-172(2014).
Nayernia, Z; Jaquet, V; et al. New Insights on NOX Enzymes in the Central Nervous System. ANTIOXIDANTS & REDOX SIGNALING 20:2815-2837(2014).