parp1
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  • Official Full Name
  • poly (ADP-ribose) polymerase 1
  • Background
  • This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase);
Cat.#:ZNF101-434HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PARP1 Protein, MYC/DDK-tagged
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Cat.#:PARP1-1658HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Poly (ADP-ribose) Polymerase 1
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Cat.#:PARP1-496HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Poly (ADP-ribose) Polymerase 1
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Cat.#:PARP1-640HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PARP1, His-tagged
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Cat.#:PARP1-430HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Poly (ADP-ribose) Polymerase 1, GST-tagged
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Cat.#:PARP1-101HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PARP1 Protein, DDK-tagged
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Cat.#:PARP1-1530HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PARP1, His-tagged
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Cat.#:PARP1-156HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PARP1 Protein, His-tagged
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Cat.#:PARP1-27540THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PARP1
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Cat.#:PARP1-30787THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PARP1
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Cat.#:PARP1-337HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PARP1
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Cat.#:PARP1-444HTag:MYC
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PARP1, MYC-tagged
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Cat.#:PARP1-451HTag:HA
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PARP1, HA-tagged
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Cat.#:PARP1-58HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PARP-1
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Cat.#:PARP1-650HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PARP1, His tagged
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Cat.#:Parp1-2535MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Parp1, His tagged
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Cat.#:Parp1-357MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Parp1 Protein, His-tagged
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Cat.#:Parp1-358MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Parp1 Protein, His-tagged
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Cat.#:PARP1-4276RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PARP1 Protein
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Cat.#:PARP1-6815CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PARP1
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Cat.#:PARP1-4040ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PARP1
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Cat.#:PARP1-710HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PARP1 cell lysate
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Cat.#:PARP1-514MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse PARP1 cell lysate
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Cat.#:Kit-1792Tag:N/A
Source (Host):Species:
Product namePARP1 Chemiluminescent Assay Kit
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Cat.#:Kit-1793Tag:N/A
Source (Host):Species:
Product namePARP1 Chemiluminescent Assay Kit (384-well)
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Cat.#:Kit-1794Tag:N/A
Source (Host):Species:
Product namePARP1 Colorimetric Assay Kit
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Involved Pathway

PARP1 involved in several pathways and played different roles in them. We selected most pathways PARP1 participated on our site, such as Base Excision Repair, Caspase cascade in apoptosis, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base Excision Repair
NEIL3; POLE3; PNKP; nth; APEX1; PCNA; SMUG1; PARP1; POLE2; TDG
Caspase cascade in apoptosis
LMNB1; DFFA; DIABLO; TOP1; TFAP2A; CASP4; ACTA1; PARP1; SATB1; CASP2
Corticotropin-releasing hormone
TCF4; CYP11A1; ECE1; JUNB; IVL; TRIM28; CRH; KRT14; CYP21A2; CYP11B1
DNA Damage Recognition in GG-NER
PARP1; COPS2; ACTR5; COPS6; COPS8; NFRKB; COPS7B; INO80E; GPS1; YY1
DNA Double-Strand Break Repair
PPP4CB; KIAA0146; PPP4R2A; PARP2; RIF1; BRE; UIMC1; RBBP8; RAD9A; PPP4R2
DNA Repair
RBBP8; RAD18; ALKBH2; USP10; ELL; KIAA0101; BAZ1B; TFPT; PPP4R2A; COPS8
Downregulation of SMAD2/3:SMAD4 transcriptional activity
RNF111; SKILB; SKIA; USP9; USP9X; SKIB; SKI; PARP1; SMAD3B; TRIM33

Protein Function

PARP1 has several biochemical functions, for example, DNA binding, NAD binding, NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP1 itself. We selected most functions PARP1 had, and list some proteins which have the same functions with PARP1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein CHD9; ZFP28; TIGD6; THRAA; PEG10; ZNF454; HOMEZB; MYCB; IRX5A; CERS2
Function NAD binding
Related Protein HPGD; HIBADHB; LDHA; IDH1; GPD1B; BDH2; AOX4; HIBADH; HIBADHA; DLD
Function NAD+ ADP-ribosyltransferase activity
Related Protein ART1; PARP1; TNKS2; ZC3HAV1; GIG2J; GIG2L; PARP15; PARP16; GIG2E; PARP6
Function R-SMAD binding
Related Protein SMAD6; MYOCD; SMAD3; PARP1; PPM1A; MEN1; SMURF1; SMAD4; AXIN1; C18orf1
Function chromatin binding
Related Protein ENY2; RBPJL; SOX9; RCC1; ATAD2B; PDX1; HINFP; CHD8; NPM2; SIX1
Function enzyme binding
Related Protein KDM4C; SCNM1-PS; TP53; EIF2AK3; HIST1H2AD; ECM1; H2AFX; RCOR3; STUB1; CALU
Function identical protein binding
Related Protein NOD1; RUNX1T1; LCK; PTS; GBP1; ADORA2A; PFKL; LUC7L; SCAND1; SEPHS1
Function poly(A) RNA binding
Related Protein CIRH1A; PRPF4B; HIST1H1C; FUBP1; ZYX; SLC16A3; EIF4A1; C14orf21; FASN; NUDT21
Function protein N-terminus binding
Related Protein ATM; SLC6A3; KCNIP1; PEX19; GLRX; NCOR2; ERCC6; KCNQ2; SMARCE1; NCOA1
Function protein binding
Related Protein BRCA2; PDE4DIP; ECD; HIPK1; PRLHR; NRXN1; DNAJB2; RTDR1; DBC1; CHRD
Function protein kinase binding
Related Protein FAM83E; SUFU; PLCG1; GSTP2; NCS1; CHRNA7; CD8A; TRAF6; HNRNPA0; MLKL
Function transcription factor binding
Related Protein ZBTB49; TRAPPC2; NAB2; KEAP1B; MDFI; VDRA; EP300; AIP; DOT1L; CREBBP
Function zinc ion binding
Related Protein MICAL2B; APOBEC3G; FAM90A1; MT1X; ADAMTS2; SOD1; BRAP; ADAM25; LPP; ZRANB2

Interacting Protein

PARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP1.
XRCC5; TP53; WRN

PARP1 Related Articles

Beck, C; Robert, I; et al. Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3. EXPERIMENTAL CELL RESEARCH 329:18-25(2014).
Kim, J; Lim, W; et al. Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:675-684(2014).