PARP1

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PARP1

Official Full Name poly (ADP-ribose) polymerase 1
Background This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Synonyms PARP1; poly (ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthase 1; poly(ADP-ribosyl)transferase; ADP-ribosyltransferase NAD(+); NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • C-Myc/DDK
    • DDK
    • GST
    • HA
    • His
    • MYC
    • MYC/DDK
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PARP1-1531H Recombinant Human PARP1 protein, His-tagged E. coli
    Human PARP1-01H Recombinant Human PARP1 protein, His-tagged E. coli His
    Human PARP1-075H Recombinant Human PARP1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Parp1-548M Recombinant Mouse Parp1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human PARP1-59H Recombinant Human PARP1 Protein E. coli
    Human PARP1-101H Recombinant Human PARP1 Protein, DDK-tagged Insect Cell DDK
    Human PARP1-1530H Recombinant Human PARP1, His-tagged E.coli His
    Human PARP1-156H Recombinant Human PARP1 Protein, His-tagged Insect Cell His
    Human PARP1-1658H Recombinant Human Poly (ADP-ribose) Polymerase 1 Insect Cell N/A
    Human PARP1-27540TH Recombinant Human PARP1 N/A
    Human PARP1-30787TH Recombinant Human PARP1 N/A
    Human PARP1-337H Recombinant Human PARP1 Mammalian Cell His
    Human PARP1-430H Recombinant Human Poly (ADP-ribose) Polymerase 1, GST-tagged Sf9 Insect Cell GST
    Human PARP1-444H Recombinant Human PARP1, MYC-tagged Sf21 Insect Cell MYC
    Human PARP1-451H Recombinant Human PARP1, HA-tagged Sf21 Insect Cell HA
    Human PARP1-496H Recombinant Human Poly (ADP-ribose) Polymerase 1 E.coli N/A
    Human PARP1-58H Recombinant Human PARP-1 Sf9 Insect Cell N/A
    Human PARP1-640H Recombinant Human PARP1, His-tagged Sf21 Insect Cell His
    Human PARP1-650H Recombinant Human PARP1, His tagged Insect Cell His
    Human PARP1-710HCL Recombinant Human PARP1 cell lysate Insect Cell N/A
    Human ZNF101-434H Recombinant Human PARP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Parp1-2535M Recombinant Mouse Parp1, His tagged Insect Cell His
    Mouse Parp1-357M Recombinant Mouse Parp1 Protein, His-tagged E.coli His
    Mouse Parp1-358M Recombinant Mouse Parp1 Protein, His-tagged E.coli His
    Mouse PARP1-514MCL Recombinant Mouse PARP1 cell lysate Insect Cell N/A
    Rat PARP1-4276R Recombinant Rat PARP1 Protein Mammalian Cell His
    Chicken PARP1-6815C Recombinant Chicken PARP1 Mammalian Cell His
    Zebrafish PARP1-4040Z Recombinant Zebrafish PARP1 Mammalian Cell His
    Kit-1792 PARP1 Chemiluminescent Assay Kit N/A
    Kit-1793 PARP1 Chemiluminescent Assay Kit (384-well) N/A
    Kit-1794 PARP1 Colorimetric Assay Kit N/A

    PARP1 involved in several pathways and played different roles in them. We selected most pathways PARP1 participated on our site, such as Base Excision Repair, Caspase cascade in apoptosis, Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base Excision Repair POLD1; HMGB1A; NEIL3; UNG; MPG; LIG3; APEX2; NEIL1; NEIL2; HMGB1B
    Caspase cascade in apoptosis LMNB1; ACTA1; CRADD; CASP4; CASP2; NUMA1; PARP1; SATB1; DIABLO; CFL2
    Corticotropin-releasing hormone ECE1; KRT14; CRHBP; CYP21A2; TBX19; CYP11B1; PARP1; CASP12; TCF4; CRH
    DNA Damage Recognition in GG-NER CETN2; COPS5; COPS7A; MCRS1; COPS6; PARP2; DDB1; PARP1; COPS4; INO80B
    DNA Double-Strand Break Repair RAD17; HTATIP; PPP4R2B; UBE2V2; KIAA0146; RAD9A; RHNO1; RIF1; TDP1; PAXIP1
    DNA Repair RAD51AP1; COPS7B; ZNF830; COPS5; PNKP; CLSPN; SMARCA5; PPP4R2; ELL; CHD1L
    Downregulation of SMAD2/3:SMAD4 transcriptional activity USP9; SKIB; USP9X; SKILB; SKI; SMAD3B; PARP1; RNF111; SKIA; TRIM33

    PARP1 has several biochemical functions, for example, DNA binding, NAD binding, NAD+ ADP-ribosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP1 itself. We selected most functions PARP1 had, and list some proteins which have the same functions with PARP1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding ZFY2; POU3F3B; SMTNL; NAT14; ZNF571; HIST3H3; BRD4; MYNN; SMAD5; HIVEP3
    NAD binding IDH1; HPGD; NDUFS2; CTBP2L; AOX4; HSD3B5; HSD11B2; IDH2; PHGDH; AOX3
    NAD+ ADP-ribosyltransferase activity TIPARP; GIG2E; GIG2O; PARP11; GIG2J; PARP8; GIG2L; SIRT6; GIG2H; GIG2Q
    R-SMAD binding SMAD3; C18orf1; SMAD6; PARP1; ZC3H3; FOXH1; SMAD2; ANKRD1; ZEB2; MEN1
    chromatin binding CCDC111; RDBP; KDM1A; AAAS; PBX2; SIRT7; NFATC3; POLG; CAPNS2; LHX2
    enzyme binding BCR; PRKCE; HIST1H2AM; NOTCH3; Txn1; KPNB1; ATP6AP2; SUDS3; EGLN1; CAV1
    identical protein binding SIAH1A; TGFB3; NME1; BNIP3L; DVL2; DNMT3A; E2F7; AGER; PRMT1; NEFL
    poly(A) RNA binding KHDRBS3; RPS27.1; SECISBP2; SRP54A; PPIE; ZCCHC8; EXOSC6; YWHAG; EIF2C3; NDUFV3
    protein N-terminus binding ALOX5AP; MORF4L1; PHB2; STX5A; NFE2; SNF8; STX5; ARF6; THAP7; SNCA
    protein binding TLX2; RSPO2; COX4I1; IMP3; RRP8; MZF1; TAL2; HIST1H4F; GATAD2A; MMRN2
    protein kinase binding RPS19; SQSTM1; EMP2; GRB7; SHC3; ACTA2; LIPE; TNIP2; TRAF6; KCNA5
    transcription factor binding SRY; PBX2; MECP2; MED6; AGTR2; CAMTA2; ZFPM1; Trl; UBE2I; KEAP1B
    zinc ion binding RNF121; UBR5; PHF20B; PCGF5A; FBXO30; ZMYM2; PHF7; KDM1B; FHL1; RNF180

    PARP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP1.

    XRCC5; TP53; WRN

    Beck, C; Robert, I; et al. Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3. EXPERIMENTAL CELL RESEARCH 329:18-25(2014).
    Kim, J; Lim, W; et al. Photodynamic therapy (PDT) resistance by PARP1 regulation on PDT-induced apoptosis with autophagy in head and neck cancer cells. JOURNAL OF ORAL PATHOLOGY & MEDICINE 43:675-684(2014).

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