pcsk1
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  • Official Full Name
  • proprotein convertase subtilisin/kexin type 1
  • Background
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]
  • Synonyms
  • PCSK1; proprotein convertase subtilisin/kexin type 1; PC1; PC3; NEC1; SPC3; BMIQ12; neuroendocrine convertase 1; prohormone convertase 1; prohormone convertase 3;
Cat.#:PCSK1-2091RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat PCSK1 Protein (111-752 aa), His-tagged
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Cat.#:PCSK1-180HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK1, His-tagged
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Cat.#:PCSK1-764HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCSK1 Protein, His-tagged
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Cat.#:PCSK1-87HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human PCSK1, His-tagged
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Cat.#:PCSK1-892HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK1, His tagged
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Cat.#:Pcsk1-1157MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pcsk1 protein, His & T7-tagged
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Cat.#:PCSK1-12513MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PCSK1 Protein
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Cat.#:PCSK1-4305RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Pcsk1 protein, His-tagged
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Cat.#:PCSK1-7222ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PCSK1
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Cat.#:PCSK1-2249HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PCSK1 cell lysate
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Involved Pathway

PCSK1 involved in several pathways and played different roles in them. We selected most pathways PCSK1 participated on our site, such as Incretin synthesis, secretion, and inactivation, Insulin processing, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Incretin synthesis, secretion, and inactivation
SPCS3; GRP; O3far1; GPR119; GPR120; SLC38A8; DPP4; PCSK1; CDX2
Insulin processing
EXOC8; RAB27A; CPN1; CPE; EXOC6; KIF5B; EXOC5; SLC30A8; PCSK2; KIF5A
Metabolism of proteins
CPB2; NAPG; NSFA; ADAMTS10; NOP56; STT3A; TOMM40; DOHH; EIF5A2; PHC2
Peptide hormone biosynthesis
CGB7; INHBAA; INHA; CGB5; PCSK1
Peptide hormone metabolism
GZMH; GPR120; GPR119; INHA; PCSK2; INHBAA; BCHE; CDX2; MBOAT4; O3far1
Synthesis, secretion, and deacylation of Ghrelin
MBOAT4; SLC38A8; PCSK1; SPCS3
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
O3far1; GPR119; PCSK1; SPCS3; CDX2; SLC38A8; DPP4
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
GPR119; DPP4; PCSK1

Protein Function

PCSK1 has several biochemical functions, for example, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK1 itself. We selected most functions PCSK1 had, and list some proteins which have the same functions with PCSK1. You can find most of the proteins on our site.
Function
Related Protein
Function serine-type endopeptidase activity
Related Protein FURIN; LOC100686744; Prss32; KLK1B24; FAM108A1; ELANE; TPSG1; HTRA1A; DPP4; GZMM

PCSK1 Related Articles

Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).