pdgfra
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  • Official Full Name
  • platelet-derived growth factor receptor, alpha polypeptide
  • Background
  • This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described.
  • Synonyms
  • PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor alpha; CD140a; PDGFR2; PDGFR-alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; CD140A; PDGFR-2; RHEPDGFRA; MGC74795
Cat.#:Pdgfra-1774MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Pdgfra Protein, Fc-tagged
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Cat.#:PDGFRA-2050HTag:Fc/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA Protein, Fc/His-tagged
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Cat.#:PDGFRA-188HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFRA Protein, His-tagged
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Cat.#:PDGFRA-3560HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFRA, His-tagged
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Cat.#:PDGFRA-147HTag:DDK/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA Protein, DDK/HIS-tagged
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Cat.#:PDGFRA-1576HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide
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Cat.#:PDGFRA-1612HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PDGFRA, GST-tagged
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Cat.#:PDGFRA-1676HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human PDGFRA
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Cat.#:PDGFRA-29161THTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PDGFRA protein, GST-tagged
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Cat.#:PDGFRA-30830THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDGFRA
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Cat.#:PDGFRA-3181HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA, His tagged
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Cat.#:PDGFRA-384HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDGFRA, GST-tagged, Active
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Cat.#:PDGFRA-662HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human PDGFRA, Fc-tagged, Biotinylated
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Cat.#:PDGFRA-7290HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDGFRA, His & GST tagged
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Cat.#:PDGFRA-824HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA, Fc tagged
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Cat.#:PDGFRA-825HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA, None tagged
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Cat.#:PDGFRA-12570MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDGFRA Protein
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Cat.#:Pdgfra-385MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Pdgfra, GST-tagged, Active
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Cat.#:Pdgfra-51RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Pdgfra, Fc tagged
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Cat.#:Pdgfra-52RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Pdgfra, His tagged
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Cat.#:PDGFRA-6314CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDGFRA
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Cat.#:PDGFRA-9027ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PDGFRA
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Cat.#:PDGFRA-1147HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, His-tagged
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Cat.#:PDGFRA-1287HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, GST-tagged
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Cat.#:PDGFRA-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDGFRA cell lysate
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Cat.#:PDGFRA-2657HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDGFRA cell lysate
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Cat.#:PDGFRA-824RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat PDGFRA cell lysate
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Cat.#:Kit-1615Tag:
Source (Host):Species:
Product namePDGFRa Functional Assay Kit
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Cat.#:Kit-1616Tag:
Source (Host):Species:
Product nameU2OS PDGFRa Bioassay Kit
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Involved Pathway

PDGFRA involved in several pathways and played different roles in them. We selected most pathways PDGFRA participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF19; IL1B; CACNG7; CACNA1SA; CACNG1A; CACNG1; CACNB4; HSC70; FGFR1; TAOK2
Ras signaling pathway
PAK2; ANGPT1; RAC2; PLA2G10; PIK3R1; GRIN2B; RASSF5; FIGF; PTPN11; LAT
Rap signaling pathway
APBB1IP; INS2; FGFR1; RAP1B; RAC2; VAV2; GRIN1; LPAR3; LAT; KRAS
Calcium signaling pathway
PPIF; PLCB3; TMEM8C; PPP3CB; PTAFR; PLCD1A; ITPKA; MLCK2; P2RX4; P2RX8
Cytokine-cytokine receptor interaction
ACVR1B; CSF2RA; CXCL8B.3; GM13304; CXCL12B; CCL26; CD40LG; GM-CSF; KITA; EPO
Phospholipase D signaling pathway
CYTH1; LPAR5; KITLG; PTGFR; PTK2B; PIP5K1C; TSC2; LPAR2; AVPR1A; AGTR1A
Endocytosis
KDRL; BC2; RAB35B; HSPA1A; SH3GLB1B; SH3GL2; EHD3; DNM3; ARPC3; VPS37A
PIK-Akt signaling pathway
G6PC; PDGFC; ITGB5; COL6A6; GNGT2; RAC1; IFNA4; FGF7; LAMA5; TP53
Focal adhesion
ACTB1; IGF1R; PTK2AB; MYLPFA; MAP2K1; BADB; FLT1; PTENA; HRASA; ITGA8
Gap junction
DRD2B; HTR2CL1; DRD2A; TUBA8L4; PLCB4; ADRB3B; PRKG2; MAP2K2; TJP1; PRKACG
Regulation of actin cytoskeleton
RRAS2; FGF17; PPP1CBL; FGF6; ARHGAP35; PIK3R3; ITGA2; FGF8; PIK3R5; ITGA9
HTLV-I infection
RANBP3; POLD4; KAT2B; TCF3; DVL2; GM-CSF; Pdgfa&Pdgfb; TBPL1; TLN1; RELA
Pathways in cancer
MAPK10; RELA; EP300; AXIN1; FGF1; LAMA4; IKBKG; WNT9B; GLI2; PTGS2
MicroRNAs in cancer
STMN1; TRP53; TPM1; SHC1; ERBB3; BMPR2; MDM4; APC2; BCL2L2; SIRT1
Glioma
CALM3; MDM2; PIK3CD; SHC3; TRP53; PDGFRA; IGF1R; MAPK3; CCND1; GRB2
Prostate cancer
SRD5A2; FOXA1; AKT2; TRP53; INS; INS2; PTEN; SMARCC2; FOXO1; IGF1
Melanoma
MET; PDGFD; AKT1; FGF10; PDGFC; MDM2; Fgf15; RAF1; Pdgfa&Pdgfb; MAPK1
Central carbon metabolism in cancer
MTOR; SLC1A5; FGFR1; TP53; C12orf5; MAP2K1; FGFR3; HKDC1; HRAS; PFKP
Choline metabolism in cancer
PDGFA; HIF1A; WASL; CHKA; TSC2; EIF4EBP1; PCYT1A; DGKA; PIK3CB; MAPK9

Protein Function

PDGFRA has several biochemical functions, for example, ATP binding, platelet-derived growth factor alpha-receptor activity, platelet-derived growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFRA itself. We selected most functions PDGFRA had, and list some proteins which have the same functions with PDGFRA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLRP4E; TAF1; PRPF4BA; RPS6KA5; MKNK2A; ALDH18A1; PET112L; SLC14A2; SYN2B; PHKG1A
Function platelet-derived growth factor alpha-receptor activity
Related Protein PDGFRA
Function platelet-derived growth factor binding
Related Protein COL1A1; COL6A1; COL1A2; Pdgfa&Pdgfb; PDGFB; PDGFA; PDGFRB; COL2A1; COL4A1; COL5A1
Function platelet-derived growth factor receptor binding
Related Protein PDGFD; ITGA5; PDGFAB; PDGFC; FIGF; VEGFA; PDGFRA; PTEN; ITGB3; IL1R1
Function protein binding
Related Protein SPATA2; CDK15; RGS14; PRDX1; ACD; LY6H; SULT1E1; SRSF2; PDIA6; CD247
Function protein homodimerization activity
Related Protein CAV2; DRD2; S100A16; SEPT12; MZF1; FLT3LG; CHRNA7; ADH1; COMMD1; NOG
Function protein kinase activity
Related Protein WNK2; CAMK2B1; TRIM24; STK25; DYRK1AA; CSNK1D; CAMKK1B; PRKAA1; GRK7B; CDK14
Function transmembrane receptor protein tyrosine kinase activity
Related Protein NPTN; KIT; INSRA; TIE1; ERBB2; ERBB4; ERBB3B; ERBB4A; EPHA4A; NTRK1
Function vascular endothelial growth factor binding
Related Protein PDGFRB; PDGFRA; NRP1; KDR
Function vascular endothelial growth factor-activated receptor activity
Related Protein NRP2; NRP1B; KDR; NRP1A; NRP2B; PDGFRA; FLT3; FLT1; NRP1; NRP2A

Interacting Protein

PDGFRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFRA.
PDGFB; CRK; PDGFA

PDGFRA Related Articles

Yi, JH; Park, BB; et al. Retrospective analysis of extra-gastrointestinal stromal tumors. WORLD JOURNAL OF GASTROENTEROLOGY 21:1845-1850(2015).
Albuquerque, A; Rios, E; et al. Evaluation of clinico-pathological features and Helicobacter pylori infection in gastric inflammatory fibroid polyps. VIRCHOWS ARCHIV 465:643-647(2014).

PDGFRA Related Gene Family

Immunoglobulins