Recombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, GST-tagged

• Cat.No.: PDGFRA-1287H
• Product Overview: Recombinant humanPDGFRA catalytic domain (amino acids 550-1089), GST-tagged was expressed ininsect cells. Its molecular weight is 89800 Dalton.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 550-1089 a.a.
• Description: PDGFRA is a cellsurface receptor tyrosine kinase which binds members of the platelet-derivedgrowth factor family. No special measures were taken to activate this kinase.PDGFRA encodes a cell surface tyrosine kinase receptor for members of theplatelet-derived growth factor family. These growth factors are mitogens forcells of mesenchymal origin. The identity of the growth factor bound to areceptor monomer determines whether the functional receptor is a homodimer ora heterodimer, composed of both platelet-derived growth factor receptor alphaand beta polypeptides.
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT + 50%glycerol.
• Molecular Weight: 89.8 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PDGFRA

Gene Information

• Gene Name: PDGFRA platelet-derived growth factor receptor,alpha polypeptide [ Homo sapiens ]
• Synonyms: PDGFRA;platelet-derived growth factor receptor, alpha polypeptide; CD140A; CD140a;PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factorreceptor; EC 2.7.10.1; PDGF-R-alpha; CD140 antigen-like family member A;CD140a antigen
• Gene ID: 5156
• mRNA Refseq: NM_006206
• Protein Refseq: NP_006197
• MIM: 173490
• UniProt ID: P16234
• Chromosome Location: 4q12
• Pathway: ATF-2 transcriptionfactor network; Calcium signaling pathway; Cytokine-cytokine receptorinteraction; Downstream signal transduction; Endocytosis; Focal adhesion; Gapjunction; Glioma; HTLV-I infection; MAPK signaling pathway; Melanoma;Pathways in cancer; PDGFR-alpha signaling pathway; Regulation of actin cytoskeleton;Signaling by PDGF
• Function: ATP binding; growthfactor binding; nucleotide binding; phosphatidylinositol 3-kinase binding;platelet-derived growth factor alpha-receptor activity; platelet-derivedgrowth factor binding; platelet-derived growth factor receptor binding;protein homodimerization activity; protein tyrosine kinase activity; receptoractivity; transmembrane receptor protein tyrosine kinase activity; vascularendothelial growth factor-activated receptor activity