Description : |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
122.67 kDa |
AA Sequence : |
MGTSHPAFLVLGCLLTGLSLILCQL SLPSILPNENEKVVQLNSSFSLRCF GESEVSWQYPMSEEESSDVEIRNEE NNSGLFVTVLEVSSASAAHTGLYTC YYNHTQTEENELEGRHIYIYVPDPD VAFVPLGMTDYLVIVEDDDSAIIPC RTTDPETPVTLHNSEGVVPASYDSR QGFNGTFTVGPYICEATVKGKKFQT IPFNVYALKATSELDLEMEALKTVY KSGETIVVTCAVFNNEVVDLQWTYP GEVKGKGITMLEEIKVPSIKLVYTL TVPEATVKDSGDYECAARQATREVK EMKKVTISVHEKGFIEIKPTFSQLE AVNLHEVKHFVVEVRAYPPPRISWL KNNLTLIENLTEITTDVEKIQEIRY RSKLKLIRAKEEDSGHYTIVAQNED AVKSYTFELLTQVPSSILDLVDDHH GSTGGQTVRCTAEGTPLPDIEWMIC KDIKKCNNETSWTILANNVSNIITE IHSRDRSTVEGRVTFAKVEETIAVR CLAKNLLGAENRELKLVAPTLRSEL TVAAAVLVLLVIVIISLIVLVVIWK QKPRYEIRWRVIESISPDGHEYIYV DPMQLPYDSRWEFPRDGLVLGRVLG SGAFGKVVEGTAYGLSRSQPVMKVA VKMLKPTARSSEKQALMSELKIMTH LGPHLNIVNLLGACTKSGPIYIITE YCFYGDLVNYLHKNRDSFLSHHPEK PKKELDIFGLNPADESTRSYVILSF ENNGDYMDMKQADTTQYVPMLERKE VSKYSDIQRSLYDRPASYKKKSMLD SEVKNLLSDDNSEGLTLLDLLSFTY QVARGMEFLASKNCVHRDLAARNVL LAQGKIVKICDFGLARDIMHDSNYV SKGSTFLPVKWMAPESIFDNLYTTL SDVWSYGILLWEIFSLGGTPYPGMM VDSTFYNKIKSGYRMAKPDHATSEV YEIMVKCWNSEPEKRPSFYHLSEIV ENLLPGQYKKSYEKIHLDFLKSDHP AVARMRVDSDNAYIGVTYKNEEDKL KDWEGGLDEQRLSADSGYIIPLPDI DPVPEEEDLGKRNRHSSQTSEESAI ETGSSSSTFIKREDETIEDIDMMDD IGIDSSDLVEDSFLTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |