Recombinant Human Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, His-tagged

• Cat.No.: PDGFRA-1147H
• Product Overview: Recombinant Human PDGFRA, fusedwith a His-tag at N-terminus, was expressed in E. coli and purifed byconventional chromatography, after refolding of the isolated inclusion bodiesin a renaturation buffer.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: PDGFRA, also knownas platelet derived growth factor receptor alpha, is a cell surface tyrosinekinase receptor for members of the platelet-derived growth factor family.This protein can bind to both A and B subunits of PDGF. It is particularlyimportant for kidney development since mice heterozygous for the receptorexhibit defective kidney phenotypes.
• Concentration: 0.5 mg/ml
• Form: Suppliedas a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, 0.1MNaCl and 1mM DTT.
• Purity: > 85% by SDS-PAGE
• Sequence: 24-524 amino acids:MGSSHHHHHH SSGLVPRGSH MQLSLPSILP NENEKVVQLN SSFSLRCFGE SEVSWQYPMS EEESSDVEIRNEENNSGLFV TVLEVSSASA AHTGLYTCYY NHTQTEENEL EGRHIYIYVP DPDVAFVPLG MTDYLVIVEDDDSAIIPCRT TDPETPVTLH NSEGVVPASY DSRQGFNGTF TVGPYICEAT VKGKKFQTIP FNVYALKATSELDL.
• Molecular Mass: 58.4 kDa(522 aa)
• Applications: SDS-PAGE
• Storage: Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor -70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
• OfficialSymbol: PDGFRA

Gene Information

• Gene Name: PDGFRA platelet-derived growthfactor receptor, alpha polypeptide [ Homo sapiens ]
• Synonyms: PDGFRA;platelet-derived growth factor receptor, alpha polypeptide; CD140A;PDGFR2; MGC74795; RHEPDGFRA; Alpha-type platelet-derived growth factor receptor; PDGF-R-alpha; EC 2.7.10.1; CD140antigen-like family member A; CD140a antigen; CD140a; EC 2.7.10; rearranged-in-hypereosinophilia-platelet derived growth factorreceptor alpha fusion protein; PDGFRA/BCR fusion; OTTHUMP00000218653; OTTHUMP00000218654; OTTHUMP00000218655;OTTHUMP00000218656; OTTHUMP00000218657; OTTHUMP00000218658; OTTHUMP00000158882
• Gene ID: 5156
• mRNA Refseq: NM_006206
• Protein Refseq: NP_006197
• MIM: 173490
• UniProt ID: P16234
• Chromosome Location: 4q12
• Pathway: Calcium signaling pathway;Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Focaladhesion; Gap junction; Glioma; Pathways in cancer; Regulation of actincytoskeleton; Signaling by PDGF
• Function: ATP binding; nucleotidebinding; platelet-derived growth factor alpha-receptor activity;platelet-derived growth factor binding; platelet-derived growth factorreceptor binding; protein heterodimerization activity; receptor activity;transferase activity; vascular endothelial growth factor receptor activity