Recombinant Human PDGFRA protein(Met1-Glu524), hFc-tagged

• Cat.No.: PDGFRA-824H
• Product Overview: Recombinant Human PDGFRα (NP_006197.1)(Met 1-Glu 524) was expressed in HEK293, fused with the Fc region of Human IgG1 at the C-terminus.

Specification

• Source: HEK293
• Species: Human
• Tag: C-hFc
• Protein length: Met1-Glu524
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: Measured by its ability to bind human PDGFC-His a functional ELISA.
• Molecular Mass: The recombinant human PDGFRα/Fc is a disulfide-linked homodimeric protein after removal of the signal peptide. The reduced monomer consists of 739 amino acids and predicts a molecular mass of 82.9 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhPDGFRα/Fc is approximately 120-130 kDa due to the glycosylation.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 90 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: PDGFRA platelet-derived growth factor receptor, alpha polypeptide [ Homo sapiens ]
• Official Symbol: PDGFRA
• Synonyms: PDGFRA; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor alpha; CD140a; PDGFR2; PDGFR-alpha; PDGF-R-alpha; CD140a antigen; PDGFRA/BCR fusion; CD140 antigen-like family member A; platelet-derived growth factor receptor 2; alpha-type platelet-derived growth factor receptor; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; CD140A; PDGFR-2; RHEPDGFRA; MGC74795
• Gene ID: 5156
• mRNA Refseq: NM_006206
• Protein Refseq: NP_006197
• MIM: 173490
• UniProt ID: P16234

Reviews

08/16/2022

The staff had a good attitude, actively communicated with me and solved many technical problems.

07/21/2022

Cheap price, high quality products, worth buying again!

02/04/2022

The high quality of the purchased protein helped me to obtain satisfactory experimental results.

Q&As

What are the effects of overexpressing PDGFRA?

Overexpression of PAGFRA promotes cancer cell proliferation and invasion and inhibits apoptosis.

What biological processes are PDGFRA involved in?

PDGFRA is involved in physiological processes such as normal organ development, tissue damage repair and malignant tumor progression.

What diseases has PDGFRA been closely associated with the study of?

PDGFRA is closely related to the study of gastrointestinal mesenchymal tumors, ovarian cancer and other diseases.

What is the relationship of PAGFRA to PDGF?

PDGFRA binds to PDGF to regulate cell proliferation and differentiation.