| Description : |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
120.3 kDa |
| AA Sequence : |
MGTSHPAFLVLGCLLTGLSLILCQL SLPSILPNENEKVVQLNSSFSLRCF GESEVSWQYPMSEEESSDVE IRNEENNSGLFVTVLEVSSASAAHT GLYTCYYNHTQTEENELEGRHIYIY VPDPDVAFVPLGMTDYLVIV EDDDSAIIPCRTTDPETPVTLHNSE GVVPASYDSRQGFNGTFTVGPYICE ATVKGKKFQTIPFNVYALKA TSELDLEMEALKTVYKSGETIVVTC AVFNNEVVDLQWTYPGEVKGKGITM LEEIKVPSIKLVYTLTVPEA TVKDSGDYECAARQATREVKEMKKV TISVHEKGFIEIKPTFSQLEAVNLH EVKHFVVEVRAYPPPRISWL KNNLTLIENLTEITTDVEKIQEIRY RSKLKLIRAKEEDSGHYTIVAQNED AVKSYTFELLTQVPSSILDL VDDHHGSTGGQTVRCTAEGTPLPDI EWMICKDIKKCNNETSWTILANNVS NIITEIHSRDRSTVEGRVTF AKVEETIAVRCLAKNLLGAENRELK LVAPTLRSELTVAAAVLVLLVIVII SLIVLVVIWKQKPRYEIRWR VIESISPDGHEYIYVDPMQLPYDSR WEFPRDGLVLGRVLGSGAFGKVVEG TAYGLSRSQPVMKVAVKMLK PTARSSEKQALMSELKIMTHLGPHL NIVNLLGACTKSGPIYIITEYCFYG DLVNYLHKNRDSFLSHHPEK PKKELDIFGLNPADESTRSYVILSF ENNGDYMDMKQADTTQYVPMLERKE VSKYSDIQRSLYDRPASYKK KSMLDSEVKNLLSDDNSEGLTLLDL LSFTYQVARGMEFLASKNCVHRDLA ARNVLLAQGKIVKICDFGLA RDIMHDSNYVSKGSTFLPVKWMAPE SIFDNLYTTLSDVWSYGILLWEIFS LGGTPYPGMMVDSTFYNKIK SGYRMAKPDHATSEVYEIMVKCWNS EPEKRPSFYHLSEIVENLLPGQYKK SYEKIHLDFLKSDHPAVARM RVDSDNAYIGVTYKNEEDKLKDWEG GLDEQRLSADSGYIIPLPDIDPVPE EEDLGKRNRHSSQTSEESAI
ETGSSSSTFIKREDETIEDIDMMDD IGIDSSDLVEDSFLTRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways : |
Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
