|Official Full Name||plasminogen activator, tissue|
|Background||Tissue plasminogen activator (abbreviated TPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 22.214.171.124) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma.|
|Synonyms||PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PLAT involved in several pathways and played different roles in them. We selected most pathways PLAT participated on our site, such as Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Complement and coagulation cascades||C4A; PLAUR; F3; F2R; PROC; CFB; THBD; C6; F13B; SERPINE1|
|Transcriptional misregulation in cancer||EYA1; GOLPH3; ERG; GZMB; BCL2L1; SSX2; SP1; MEF2C; H3F3A; Pdgfa&Pdgfb|
PLAT has several biochemical functions, for example, glycoprotein binding, phosphoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAT itself. We selected most functions PLAT had, and list some proteins which have the same functions with PLAT. You can find most of the proteins on our site.
|glycoprotein binding||BBC3; SELP; ERBB2; Itgam&Itgb2; ITGB2; SDCBP; FBXO27; RAB14; FGFR1; IDE|
|phosphoprotein binding||TBL2; MTOR; PRKCSH; CSNK1D; IGF2R; MID1; PKD2; CBX4; LRP11; THRAP3|
|protein binding||ICAM4; HYPM; TM4SF4; DULLARD; NME7; TUB; EPHA4; MIEN1; PCBD1; ATP6V0A4|
|receptor binding||CRAT; CADM1A; SLC27A2; PVRL1A; CTNND1; TAC3; ECI2; APOF; HRG; TAC4|
|serine-type endopeptidase activity||F9B; CELA2A; ST14; HPR; TPSAB1; KLK6; ST14B; PRTN3; HABP2; LPA|
PLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAT.