PLAT

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PLAT

Official Full Name plasminogen activator, tissue
Background Tissue plasminogen activator (abbreviated TPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma.
Synonyms PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
    • Species :
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • His
    • GST
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PLAT -77H Recombinant Human tissue plasminogen activator, single chain, FITC labeled CHO N/A
    Human PLAT -78H Recombinant Human tissue plasminogen activator, single chain, Texas Red CHO N/A
    Human PLAT -79H Non-cleavable Recombinant Human Tpa Insect Cell N/A
    Human PLAT -80H Non-enzymatic non-cleavable Recombinant Human tPA Insect Cell N/A
    Human PLAT-051H Recombinant Human PLAT Protein, His-tagged HEK293 His
    Human PLAT-052H Recombinant Human PLAT Protein, GST and His-tagged E.coli GST/His
    Human PLAT-1109H Recombinant Human PLAT protein, His-tagged CHO His
    Human PLAT-1290H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
    Human PLAT-1291H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
    Human PLAT-1292H Recombinant Human Plasminogen Activator, Tissue Insect Cell N/A
    Human PLAT-142H Tissue Plasminogen Activator (tPA) Antigen in Plasma Reference standard N/A
    Human PLAT-169H Recombinant Human Tissue Plasminogen Activator Reference standard N/A
    Human PLAT-1870H Recombinant Human PLAT Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PLAT-2737H Recombinant Human PLAT protein, His-tagged E.coli His
    Human PLAT-2738H Recombinant Human PLAT protein, His & GST-tagged E.coli His/GST
    Human PLAT-2833HCL Recombinant Human PLAT cell lysate Human Cell N/A
    Human PLAT-29690TH Native Human Human SERPINE1 N/A
    Human PLAT-30920TH Native Human PLAT N/A
    Human PLAT-30946TH Native Human PLAT N/A
    Human PLAT-3123H Recombinant Human PLAT, Fc-His tagged Human Cell Fc/His
    Human PLAT-36H Reteplase Reference standard N/A
    Human PLAT-5461H Recombinant Human Plasminogen Activator, Tissue CHO N/A
    Human PLAT-55H Recombinant Human Plasminogen Activator, Tissue CHO N/A
    Human PLAT-72H Recombinant Human PLAT, Fc tagged Human Cell Fc
    Human PLAT-8525H Recombinant Human PLAT, Fc-tagged Human Cell Fc
    Human PLAT-882H Recombinant Human PLAT, None tagged Human Cell N/A
    Human PLAT-P005H Recombinant Human PLAT therapeutic protein CHO N/A
    Human PLAT-P033H Recombinant Human PLAT therapeutic protein CHO N/A
    Mouse PLAT-1498MCL Recombinant Mouse PLAT cell lysate Human Cell N/A
    Mouse Plat-2739M Recombinant Mouse Plat protein, His-tagged E.coli His
    Mouse Plat-5463M Recombinant Mouse Plasminogen Activator, Tissue Insect Cell N/A
    Mouse PLAT-926M Recombinant Mouse PLAT Protein, Fc-tagged HEK293 Fc
    Rat Plat -95R Recombinant Active rat tPA Insect Cell N/A
    Rat Plat -96R Recombinant Active rat tPA, two chain Insect Cell N/A
    Rat Plat-2741R Recombinant Rat Plat protein, His-tagged E.coli His
    Rat PLAT-4494R Recombinant Rat PLAT Protein Mammalian Cell His
    Rat Plat-5462R Recombinant Rat Plasminogen Activator, Tissue Insect Cell N/A
    Rabbit PLAT -90R Recombinant Active Rabbit tPA Insect Cell N/A
    Pig PLAT -84P Recombinant Active porcine tPA Insect Cell N/A
    Pig PLAT-1293P Recombinant Pig Plasminogen Activator, Tissue Insect Cell N/A
    Pig PLAT-2740P Recombinant Pig PLAT protein, His & GST-tagged E.coli His/GST
    Kit-0701 PLAT (Human) Chromogenic Activity Assay Kit N/A

    PLAT involved in several pathways and played different roles in them. We selected most pathways PLAT participated on our site, such as Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades C4A; PLAUR; F3; F2R; PROC; CFB; THBD; C6; F13B; SERPINE1
    Transcriptional misregulation in cancer EYA1; GOLPH3; ERG; GZMB; BCL2L1; SSX2; SP1; MEF2C; H3F3A; Pdgfa&Pdgfb

    PLAT has several biochemical functions, for example, glycoprotein binding, phosphoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAT itself. We selected most functions PLAT had, and list some proteins which have the same functions with PLAT. You can find most of the proteins on our site.

    Function Related Protein
    glycoprotein binding BBC3; SELP; ERBB2; Itgam&Itgb2; ITGB2; SDCBP; FBXO27; RAB14; FGFR1; IDE
    phosphoprotein binding TBL2; MTOR; PRKCSH; CSNK1D; IGF2R; MID1; PKD2; CBX4; LRP11; THRAP3
    protein binding ICAM4; HYPM; TM4SF4; DULLARD; NME7; TUB; EPHA4; MIEN1; PCBD1; ATP6V0A4
    receptor binding CRAT; CADM1A; SLC27A2; PVRL1A; CTNND1; TAC3; ECI2; APOF; HRG; TAC4
    serine-type endopeptidase activity F9B; CELA2A; ST14; HPR; TPSAB1; KLK6; ST14B; PRTN3; HABP2; LPA

    PLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAT.

    SERPINE1; Plgrkt

    Jiang, WL; Zheng, Z; et al. Demodulation for hydraulic pump fault signals based on local mean decomposition and improved adaptive multiscale morphology analysis. MECHANICAL SYSTEMS AND SIGNAL PROCESSING 58-59:179-205(2015).
    Didenko, AN; Vodovozov, VY; et al. Paleomagnetism of the Ulkan massif (SE Siberian platform) and the apparent polar wander path for Siberia in late Paleoproterozoic-early Mesoproterozoic times. PRECAMBRIAN RESEARCH 259:58-77(2015).

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