plat
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  • Official Full Name
  • plasminogen activator, tissue
  • Background
  • Tissue plasminogen activator (abbreviated TPA or PLAT) is a protein involved in the breakdown of blood clots. It is a serine protease (EC 3.4.21.68) found on endothelial cells, the cells that line the blood vessels. As an enzyme, it catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for clot breakdown. Because it works on the clotting system, tPA is used in clinical medicine to treat only embolic or thrombotic stroke. Use is contraindicated in hemorrhagic stroke and head trauma.
  • Synonyms
  • PLAT; plasminogen activator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogen activator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784; OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787; OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
Cat.#:PLAT-1870HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT Protein, MYC/DDK-tagged
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Cat.#:PLAT-5461HTag:N/A
Source (Host):CHO cellsSpecies:Human
Product nameRecombinant Human Plasminogen Activator, Tissue
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Cat.#:Plat-5463MTag:N/A
Source (Host):Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Plasminogen Activator, Tissue
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Cat.#:Plat-5462RTag:N/A
Source (Host):Insect cellsSpecies:Rat
Product nameRecombinant Rat Plasminogen Activator, Tissue
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Cat.#:PLAT-55HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Plasminogen Activator, Tissue
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Cat.#:PLAT -77HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human tissue plasminogen activator, single chain, FITC labeled
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Cat.#:PLAT -78HTag:N/A
Source (Host):CHOSpecies:Human
Product nameRecombinant Human tissue plasminogen activator, single chain, Texas Red
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Cat.#:PLAT -79HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameNon-cleavable Recombinant Human Tpa
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Cat.#:PLAT -80HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameNon-enzymatic non-cleavable Recombinant Human tPA
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Cat.#:PLAT-051HTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameRecombinant Human PLAT Protein, His-tagged
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Cat.#:PLAT-052HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLAT Protein, GST and His-tagged
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Cat.#:PLAT-1109HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human PLAT protein, His-tagged
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Cat.#:PLAT-2737HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLAT protein, His-tagged
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Cat.#:PLAT-2738HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLAT protein, His & GST-tagged
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Cat.#:PLAT-3123HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT, Fc-His tagged
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Cat.#:PLAT-72HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT, Fc tagged
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Cat.#:PLAT-8525HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT, Fc-tagged
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Cat.#:PLAT-882HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT, None tagged
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Cat.#:Plat-2739MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Plat protein, His-tagged
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Cat.#:PLAT-926MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PLAT Protein, Fc-tagged
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Cat.#:Plat -95RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Active rat tPA
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Cat.#:Plat -96RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rat
Product nameRecombinant Active rat tPA, two chain
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Cat.#:Plat-2741RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Plat protein, His-tagged
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Cat.#:PLAT-4494RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLAT Protein
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Cat.#:PLAT -90RTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Rabbit
Product nameRecombinant Active Rabbit tPA
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Cat.#:PLAT -84PTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Pig
Product nameRecombinant Active porcine tPA
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Cat.#:PLAT-2740PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig PLAT protein, His & GST-tagged
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Cat.#:PLAT-1290HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Plasminogen Activator, Tissue
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Cat.#:PLAT-1291HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Plasminogen Activator, Tissue
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Cat.#:PLAT-1292HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Plasminogen Activator, Tissue
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Cat.#:PLAT-1293PTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Pig
Product nameRecombinant Pig Plasminogen Activator, Tissue
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Cat.#:PLAT-29690THTag:
Source (Host):Species:Human
Product nameNative Human Human SERPINE1
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Cat.#:PLAT-30920THTag:
Source (Host):Species:Human
Product nameNative Human PLAT
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Cat.#:PLAT-30946THTag:
Source (Host):NativeSpecies:Human
Product nameNative Human PLAT
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Cat.#:PLAT-2833HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLAT cell lysate
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Cat.#:PLAT-1498MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse PLAT cell lysate
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Cat.#:Kit-0701Tag:
Source (Host):Species:
Product namePLAT (Human) Chromogenic Activity Assay Kit
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Cat.#:PLAT-142HTag:
Source (Host):Species:Human
Product nameTissue Plasminogen Activator (tPA) Antigen in Plasma Reference standard
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Cat.#:PLAT-169HTag:
Source (Host):Species:Human
Product nameRecombinant Human Tissue Plasminogen Activator Reference standard
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Cat.#:PLAT-36HTag:
Source (Host):Species:Human
Product nameReteplase Reference standard
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Cat.#:PLAT-P005HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human PLAT therapeutic protein
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Cat.#:PLAT-P033HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human PLAT therapeutic protein
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Cat.#:CSC-TP023Tag:
Source (Host):CHOSpecies:Human
Product nameHuman PLAT Stable Cell Line-CHO
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Cat.#:CSC-TP025Tag:
Source (Host):CHOSpecies:Human
Product nameHuman PLAT Stable Cell Line-CHO
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Cat.#:CSC-TP038Tag:
Source (Host):CHOSpecies:Human
Product nameHuman PLAT Stable Cell Line-CHO
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Cat.#:CSC-TP053Tag:
Source (Host):CHOSpecies:Human
Product nameHuman PLAT Stable Cell Line-CHO
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Involved Pathway

PLAT involved in several pathways and played different roles in them. We selected most pathways PLAT participated on our site, such as Complement and coagulation cascades, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Complement and coagulation cascades
Serpina1b; FGA; MASP2; PROC; F13A1; C1QC; C9; THBD; PLAT; C5
Transcriptional misregulation in cancer
SS18; H3F3C; SFPI1; LYL1; FCGR1; EWSR1; RXRB; PAX7; IL3; FOXO1

Protein Function

PLAT has several biochemical functions, for example, glycoprotein binding, phosphoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLAT itself. We selected most functions PLAT had, and list some proteins which have the same functions with PLAT. You can find most of the proteins on our site.
Function
Related Protein
Function glycoprotein binding
Related Protein FBXO6; FLNA; EDEM2; F7; ITGB2; BMPR1B; SERPINA1; CALR; VWF; CANX
Function phosphoprotein binding
Related Protein SERPINB1A; CSNK1D; URI1; TRPV1; PLAT; DPYS; TBL2; PKD2; MS4A2; PIH1D1
Function protein binding
Related Protein THG1L; LMX1B; CD2AP; MFF; TWSG1; IL1RAPL1; AK8; STXBP3; TBC1D2; MAGEF1
Function receptor binding
Related Protein ANG; AGXT; RND1; PVRL4; CD58; NRXN1; PDGFRB; NRG4; NSG1; PECR
Function serine-type endopeptidase activity
Related Protein ELA3L; ELA2L; KLK4; F7I; Gzmd; TMPRSS7; C1RA; KLK12; PLAUB; ST14B

Interacting Protein

PLAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLAT here. Most of them are supplied by our site. Hope this information will be useful for your research of PLAT.
SERPINE1; Plgrkt

PLAT Related Articles

Jiang, WL; Zheng, Z; et al. Demodulation for hydraulic pump fault signals based on local mean decomposition and improved adaptive multiscale morphology analysis. MECHANICAL SYSTEMS AND SIGNAL PROCESSING 58-59:179-205(2015).
Didenko, AN; Vodovozov, VY; et al. Paleomagnetism of the Ulkan massif (SE Siberian platform) and the apparent polar wander path for Siberia in late Paleoproterozoic-early Mesoproterozoic times. PRECAMBRIAN RESEARCH 259:58-77(2015).