Recombinant Pig Plasminogen Activator, Tissue

• Cat.No.: PLAT-1293P
• Product Overview: Recombinant activepig PLAT that is >95% active.

Specification

• Species: Pig
• Source: Insect Cells
• Tag: Non
• Description: Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
• Form: Frozen liquid in 0.4M HEPES Buffer + 0.1 M NaCl, pH 7.4
• Molecular Weight: 70.0 kDa
• Concentration: 1.0mg/ml
• Purity: >95% by SDS-PAGEanalysis
• Endotoxin Level: < 0.1 ng/µg ofprotein
• Storage: Store at -80°C. Stablefor 3 years from delivery. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PLAT

Gene Information

• Gene Name: PLAT plasminogen activator,tissue [ Sus scrofa ]
• Synonyms: PLAT; plasminogenactivator, tissue; tissue-type plasminogen activator; tPA; t-PA;T-plasminogen activator; EC 3.4.21.68
• Gene ID: 397121
• mRNA Refseq: NM_214054
• Protein Refseq: NP_999219
• UniProt ID: Q8SQ23
• Chromosome Location: 17; 17
• Pathway: Complement andcoagulation cascades
• Function: peptidase activity;protein binding; serine-type endopeptidase activity