Recombinant Human Plasminogen Activator, Tissue

• Cat.No.: PLAT-1290H
• Product Overview: Recombinant Human PLATInactive has the active site mutation S478A which renders it catalyticallyinactive, and It is > 90% single chain and retains exosite binding as wellas other properties of wild type PLAT.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Description: Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
• Form: Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4
• Molecular Weight: 70.0 kDa
• Concentration: 2.0 mg/ml
• Storage: Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PLAT

Gene Information

• Gene Name: PLAT plasminogen activator,tissue [ Homo sapiens ]
• Synonyms: PLAT; plasminogenactivator, tissue; TPA; T-PA; DKFZp686I03148; tissue-type plasminogenactivator; alteplase; reteplase; OTTHUMP00000225783; OTTHUMP00000225784;OTTHUMP00000225785; OTTHUMP00000225786; OTTHUMP00000225787;OTTHUMP00000225788; t-plasminogen activator; plasminogen activator, tissuetype; tissue plasminogen activator (t-PA); EC 3.4.21.68
• Gene ID: 5327
• mRNA Refseq: NM_000930
• Protein Refseq: NP_000921
• MIM: 173370
• UniProt ID: P00750
• Chromosome Location: 8p12
• Pathway: Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Selenium Pathway; Senescence andAutophagy; Signal Transduction; Signaling by PDGF; amb2 Integrin signaling
• Function: peptidase activity;protein binding; serine-type endopeptidase activity