prkab1
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  • Official Full Name
  • protein kinase, AMP-activated, beta 1 non-catalytic subunit
  • Background
  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PRKAB1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK; HAMPKb; 5-AMP-activated protein kinase subunit beta-1; AMPKb; AMPK beta 1; AMPK beta -1 chain; AMPK subunit beta-1; AMP-activated protein kinase beta subunit; 5-AMP-activated protein kinase beta-1 subunit; protein kinase, AMP-activated, noncatalytic, beta-1;
Cat.#:PRKAB1-1785HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB1 protein, His & GST-tagged
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Cat.#:PRKAB1-1945HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB1, His-tagged
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Cat.#:PRKAB1-347HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human protein kinase, AMP-activated, beta 1 non-catalytic subunit, His-tagged
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Cat.#:PRKAB1-370HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAB1 protein, His/MBP-tagged
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Cat.#:PRKAB1-4865HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4866HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4867HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4868HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4869HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4870HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, AMP-Activated, Beta 1 Non-Catalytic Subunit, His-tagged
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Cat.#:PRKAB1-4670RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAB1 Protein
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Cat.#:PRKAB1-3601RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKAB1 Protein, His-tagged
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Cat.#:PRKAB1-3403CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAB1
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Cat.#:AMPK-410HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AMPK cell lysate
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Cat.#:AMPK-411HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AMPK cell lysate
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Cat.#:AMPK-412HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AMPK cell lysate
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Cat.#:AMPK-416HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AMPK cell lysate
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Cat.#:PRKAB1-2869HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKAB1 293 Cell Lysate
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Involved Pathway

PRKAB1 involved in several pathways and played different roles in them. We selected most pathways PRKAB1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PLK1; GADD45AA; S1PR4; G6PC2; CCNB3; PRKAB1; INS1; FOXO3; HRASB; MAPK12
AMPK signaling pathway
AKT2; STRADA; SCD; ACACA; HNF4A; GYS2; EEF2; PIK3R5; INS; ELAVL1
Circadian rhythm
FBXW11; PRKAG1; PER3; RBX1; PRKAA1; CUL1; PRKAB1; PRKAB2; PRKAA2; RORC
Insulin signaling pathway
HRASA; ARAF; PRKAG1; FASN; FOXO1A; PRKACG; RAF1; HKDC1; BADB; HK3
Adipocytokine signaling pathway
SOCS3B; PRKAB1A; CHUK; AKT1; MAPK9; LEPA; CAMKK1; TNF; PTPN11B; PRKCQ
Oxytocin signaling pathway
PIK3R1; PLA2G4D; PPP1R12A; GNAI2; PPP1CB; PPP1R12C; CAMKK2; PPP1CC; PIK3CB; RYR2
Glucagon signaling pathway
GYS1; CRTC2; AKT2; PYGL; CALM3; PLCB3; GNAS; PHKG1; SMEK1; PFKFB1
Insulin resistance
PRKAG3B; GSK3AA; PCK2; PYGB; GYS2; PPP1R3CB; IRS1; PIK3R2; PRKCBA; RPS6KB2
Non-alcoholic fatty liver disease (NAFLD)
ADIPOR1; MLXIPL; CASP8; NDUFB2; COX5A; MAPK8; NDUFS4; EIF2AK3; UQCR11; NDUFB10
Hypertrophic cardiomyopathy (HCM)
ACTC1; TGFB2; TNNI3; ITGA8; ITGB5; MYBPC3; TPM2; ITGA10; SGCG; ACTB

Protein Function

PRKAB1 has several biochemical functions, for example, AMP-activated protein kinase activity, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAB1 itself. We selected most functions PRKAB1 had, and list some proteins which have the same functions with PRKAB1. You can find most of the proteins on our site.
Function
Related Protein
Function AMP-activated protein kinase activity
Related Protein ALPK2; PRKAG3; PRKAA2; PRKAB1; PRKAA1; PRKAG2
Function protein binding
Related Protein SAMM50; PTPN11A; TSPAN4; SV2B; NGB; GMDS; GLS; KRT2; TIE1; ZNF830
Function protein kinase activity
Related Protein STK30; CDK5R1; RASSF2; RPS6KAL; BMPR1AA; POMK; CCL3; BUB1B; SYK; ERBB4A
Function protein kinase binding
Related Protein CEP152; CCNE2; HDAC7; LAT; RPS19; PLCG1; SYK; RB1CC1; CLTC; SPRED2

Interacting Protein

PRKAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAB1.
PRKAA1; PRKAG1; PRKAB2; CBR1; Cidea; GRB2

PRKAB1 Related Articles

Brett, KE; Ferraro, ZM; et al. Prenatal physical activity and diet composition affect the expression of nutrient transporters and mTOR signaling molecules in the human placenta. PLACENTA 36:204-212(2015).
Banerjee, S; Zagorska, A; et al. Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1 beta(MYPT1) phosphatase complex and the SCF beta TrCP E3 ubiquitin ligase. BIOCHEMICAL JOURNAL 461:233-245(2014).