prkdc
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  • Official Full Name
  • protein kinase, DNA-activated, catalytic polypeptide
  • Background
  • This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
  • Synonyms
  • PRKDC; protein kinase, DNA-activated, catalytic polypeptide; HYRC; p350; DNAPK; DNPK1; HYRC1; XRCC7; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; p460; DNA-PK catalytic subunit; hyper-radiosensitivity of murine scid mutation, complementing 1;
Cat.#:PRKDC-28357THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRKDC
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Cat.#:PRKDC-859HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PRKDC Protein
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Cat.#:PRKDC-860HTag:
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human PRKDC Protein
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Cat.#:PRKDC-13375MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKDC Protein
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Cat.#:Prkdc-1774MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prkdc protein, His & T7-tagged
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Cat.#:PRKDC-6226CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKDC
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Involved Pathway

PRKDC involved in several pathways and played different roles in them. We selected most pathways PRKDC participated on our site, such as Non-homologous end-joining, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Non-homologous end-joining
PRKDC; XRCC5; DCLRE1C; DNTT; MRE11A; XRCC6; NHEJ1; POLL; FEN1; POLM
Cell cycle
NCAPD3; KAT5; NUMA1; RAD17; CENPE; SFN; MCM4; FZR1; DCTN1; VRK1

Protein Function

PRKDC has several biochemical functions, for example, ATP binding, DNA-dependent protein kinase activity, double-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKDC itself. We selected most functions PRKDC had, and list some proteins which have the same functions with PRKDC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TRP53; TSSK3; ROR1; DAPK3; MAP3K9; AKT3; MAPK4; ETNK1; STK16; GTF2F2
Function DNA-dependent protein kinase activity
Related Protein ALPK2; PRKDC; XRCC6BP1; HMGA2; ATM
Function double-stranded DNA binding
Related Protein SETMAR; SMAD2; HMGB1; TP73; TRP53; AFF3; TDG; DDX58; IFI203; RAD51
Function enzyme binding
Related Protein MAP2K7; CBS; YWHAE; HSPA8; C6orf211; PARP1; SIRT1; MAPT; APBA3; HDAC6
Function poly(A) RNA binding
Related Protein THUMPD1; EIF4E; ZC3H10; GANAB; RRP12; PPIL4; RPL22; SRSF11; DHX33; EIF5
Function protein binding
Related Protein CCT5; FAM40A; ARAP1; ATF7; SPRTN; SRMS; MEP1B; TBL1X; NGFRB; RAB34
Function protein kinase activity
Related Protein BMPR2B; DYRK3; STK17B; STK4; FASTKD1; MAPKAPK2A; PKMYT1; MAP2K2B; MAP2K4; AKT1
Function protein serine/threonine kinase activity
Related Protein MARK4; TGFBR1B; GRK7B; ULK1; PRKCBB; LIMK2; AKT2L; HIPK3; MAP3K4; PAK3
Function transcription factor binding
Related Protein CDKN2A; AIP; KAT2A; PPP1R13BB; BCOR; TAF12; ARRB1; PPP1R13B; PIK3R1; CREBBP

Interacting Protein

PRKDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKDC here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKDC.
XRCC6; XRCC5; PIDD1; CASP2

PRKDC Related Articles

Wang, XL; Cho, SY; et al. C-X-C motif chemokine 12 influences the development of extramedullary hematopoiesis in the spleens of myelofibrosis patients. EXPERIMENTAL HEMATOLOGY 43:100-109(2015).
Klanova, M; Soukup, T; et al. Mouse models of mantle cell lymphoma, complex changes in gene expression and phenotype of engrafted MCL cells: implications for preclinical research. LABORATORY INVESTIGATION 94:806-817(2014).