prmt1
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  • Official Full Name
  • protein arginine methyltransferase 1
  • Background
  • This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
  • Synonyms
  • PRMT1; protein arginine methyltransferase 1; ANM1; HCP1; IR1B4; HRMT1L2; protein arginine N-methyltransferase 1; interferon receptor 1-bound protein 4; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2;
Cat.#:PRMT1-3005HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRMT1 Protein, MYC/DDK-tagged
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Cat.#:PRMT1-5040HTag:His/Myc
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PRMT1 Protein, His-MBP-tagged
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Cat.#:PRMT1-5041HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PRMT1 Protein, GST-tagged
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Cat.#:PRMT1-1616HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Arginine Methyltransferase 1, GST-tagged
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Cat.#:PRMT1-1761HTag:His/Myc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Protein Arginine Methyltransferase 1, His-MBP-tagged
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Cat.#:Prmt1-1762MTag:His/Myc
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Protein Arginine N-methyltransferase 1, His-MBP-tagged
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Cat.#:PRMP1-678HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PRMP1, His-tagged
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Cat.#:Prmt1-711RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Protein Arginine Methyltransferase 1
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Cat.#:PRMT1-123HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMT1 protein, T7/His-tagged
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Cat.#:PRMT1-181HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRMT1, GST-tagged
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Cat.#:PRMT1-1967HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMT1, GST-tagged
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Cat.#:PRMT1-31112THTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMT1 protein, GST-tagged
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Cat.#:PRMT1-31114THTag:MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMT1, MBP-tagged
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Cat.#:PRMT1-623HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PRMT1
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Cat.#:PRMT2-67HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRMT2, FLAG-tagged
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Cat.#:PRMT1-4705RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRMT1 Protein
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Cat.#:PRMT1-10921ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRMT1
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Cat.#:PRMT1-59HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMP1, His-tagged
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Cat.#:PRMT1-500HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRMT1 lysate
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Cat.#:Kit-1853Tag:
Source (Host):Species:
Product namePRMT1 Chemiluminescent Assay Kit
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Cat.#:Kit-1854Tag:
Source (Host):Species:
Product namePRMT1 Homogeneous Assay Kit
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Involved Pathway

PRMT1 involved in several pathways and played different roles in them. We selected most pathways PRMT1 participated on our site, such as FoxO signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
PTENB; MAPK8B; PRKAA2; CCNG2; HOMER1B; EGFRA; NRAS; SMAD4; SMAD3A; MAPK12B
Glucagon signaling pathway
PRKACA; GCG; ATF4; PDHA2; PRKAG1; PYGL; PLCB3; PPP3CA; SLC2A1; FOXO1

Protein Function

PRMT1 has several biochemical functions, for example, N-methyltransferase activity, enzyme binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT1 itself. We selected most functions PRMT1 had, and list some proteins which have the same functions with PRMT1. You can find most of the proteins on our site.
Function
Related Protein
Function N-methyltransferase activity
Related Protein PRDM11; METTL21D; METTL7B; RNMTL1B; PRDM12; FAM86; METTL23; PRDM13; PRMT8B; RNMTL1A
Function enzyme binding
Related Protein DNM2; GOT2; PPARG; MDM4; UGT1A4; KDM4C; PRMT1; FOXO4; ABCD1; NOTCH3
Function histone methyltransferase activity
Related Protein EED; SUZ12; PRMT2; PRMT1; CARM1; EZH2; PRDM13; SUV39H1; PRMT6
Function histone methyltransferase activity (H4-R3 specific)
Related Protein PRMT8; PRMT8B; PRMT1; PRMT7; PRMT6
Function identical protein binding
Related Protein RAD51; TNN; BRAP; CLDN11; ALDOA; PFKFB1; ALAD; IGF2R; CNTN2; SH3GL2
Function methyltransferase activity
Related Protein NSUN6; COMTA; METTL22; PRDM15; SETDB1B; METTL4; Mettl11b; EHMT1B; PRDM13; PRMT8B
Function mitogen-activated protein kinase p38 binding
Related Protein SPAG9; NFATC1; PRMT1; RPS6KA4; TAB1
Function poly(A) RNA binding
Related Protein RPS3; CHST13; ELAC2; SLIRP; CHD2; PCBP3; SR140; PNPT1; ARHGEF1; ANKHD1
Function protein binding
Related Protein NUP155; LIN28B; UGGT2; FMNL1; AGPAT4; CCK; CEBPA; EPN3; CEP57L1; VRK2
Function protein methyltransferase activity
Related Protein METTL21D; NDUFAF5; METTL7B; METTL23; TRMT10B; METTL21A; DIMT1; PRMT8B; FBLL1; PRDM12
Function protein-arginine N-methyltransferase activity
Related Protein DIMT1; METTL7B; RNMTL1B; RNMTL1A; NDUFAF5; PRMT2; PRDM11; TRMT10B; PRMT3; PRDM13
Function protein-arginine omega-N asymmetric methyltransferase activity
Related Protein PRMT2; PRMT3; PRMT6; PRMT8B; PRMT1; PRMT7; PRMT8; CARM1

Interacting Protein

PRMT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT1.
HNRNPR; NRIP1; HNRNPK; SPEG; WDYHV1

PRMT1 Related Articles

Fujimoto, K; Kurokawa, R; et al. Development of a mouse monoclonal antibody for the detection of asymmetric dimethylarginine of Translocated in LipoSarcoma/FUsed in Sarcoma and its application in analyzing methylated TLS. CELL AND BIOSCIENCE 4:-(2014).
Bikkavilli, RK; Avasarala, S; et al. In vitro Methylation Assay to Study Protein Arginine Methylation. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS :-(2014).