PTPN2

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PTPN2

Official Full Name protein tyrosine phosphatase, non-receptor type 2
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Synonyms PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PTPN2-1519H Recombinant Human PTPN2 (Active), GST-tagged E.coli GST
    Human PTPN2-2056H Recombinant Human PTPN2, GST-tagged E.coli GST
    Human PTPN2-3131H Recombinant Human PTPN2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PTPN2-464H Recombinant Human PTPN2,GST-tagged,Active E.coli GST
    Human PTPN2-470H Recombinant Human PTPN2, Gly & Pro tagged Insect Cell His
    Human PTPN2-567HCL Recombinant Human PTPN2 cell lysate Insect Cell N/A
    Human PTPN2-8088H Recombinant Human PTPN2 protein, His & T7-tagged E.coli His/T7
    Human PTPN2-940H Recombinant Human PTPN2, His & GST tagged Insect Cell His/GST
    Mouse Ptpn2-2548M Recombinant Mouse Ptpn2, His tagged Insect Cell His
    Mouse PTPN2-533MCL Recombinant Mouse PTPN2 cell lysate Insect Cell N/A
    Mouse Ptpn2-8089M Recombinant Mouse Ptpn2 protein, His & T7-tagged E.coli His/T7
    Rat PTPN2-4831R Recombinant Rat PTPN2 Protein Mammalian Cell His
    Chicken PTPN2-4267C Recombinant Chicken PTPN2 Mammalian Cell His

    PTPN2 involved in several pathways and played different roles in them. We selected most pathways PTPN2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway IL21R.1; RAF1; CSF3R; IL20RB; PIM1; IL2RG; IFNA16; IL6R; IL23R; IL13RA2

    PTPN2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN2 itself. We selected most functions PTPN2 had, and list some proteins which have the same functions with PTPN2. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding ILK; NF2; TGFBI; CTGFA; FN1A; LAMB2; ADAM23; NISCH; THBS1; WISP1A
    protein binding CCNB3; PAK6; KCTD14; HBA2; SH3BP4; FOXH1; HAGH; MTM1; AMOTL2A; BNIP3L
    protein kinase binding ADIPOR1; SMAD1; IBTK; KCNA5; PRDX3; PTPN1; NCS1; AGAP2; GRIN2A; CNPPD1
    protein tyrosine phosphatase activity DUSP7; MTM1; PALD1; PTPRG; CDC14B; EYA2; PTPN23; PTPN13; PALD1A; PTPRC
    receptor tyrosine kinase binding PTPN2; ZNF259; TOB1; GNB2L1; PTPN14; ANGPT1; HYAL2; SQSTM1; PITPNM3; Flt3l
    syntaxin binding SYT15; TMED10; STX16; SYTL3; ABCA1; STX8; SNAP23.1; SYT16; PTPN2; SNAP23.2

    PTPN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN2.

    GHR; ITGA1; WASL; CDC42; INSR; SFN; UCHL5; q5ni33_fratt; PSMC1; EGFR

    Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
    Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).

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