|Official Full Name||protein tyrosine phosphatase, non-receptor type 2|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]|
|Synonyms||PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PTPN2 involved in several pathways and played different roles in them. We selected most pathways PTPN2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Jak-STAT signaling pathway||IL21R.1; RAF1; CSF3R; IL20RB; PIM1; IL2RG; IFNA16; IL6R; IL23R; IL13RA2|
PTPN2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN2 itself. We selected most functions PTPN2 had, and list some proteins which have the same functions with PTPN2. You can find most of the proteins on our site.
|integrin binding||ILK; NF2; TGFBI; CTGFA; FN1A; LAMB2; ADAM23; NISCH; THBS1; WISP1A|
|protein binding||CCNB3; PAK6; KCTD14; HBA2; SH3BP4; FOXH1; HAGH; MTM1; AMOTL2A; BNIP3L|
|protein kinase binding||ADIPOR1; SMAD1; IBTK; KCNA5; PRDX3; PTPN1; NCS1; AGAP2; GRIN2A; CNPPD1|
|protein tyrosine phosphatase activity||DUSP7; MTM1; PALD1; PTPRG; CDC14B; EYA2; PTPN23; PTPN13; PALD1A; PTPRC|
|receptor tyrosine kinase binding||PTPN2; ZNF259; TOB1; GNB2L1; PTPN14; ANGPT1; HYAL2; SQSTM1; PITPNM3; Flt3l|
|syntaxin binding||SYT15; TMED10; STX16; SYTL3; ABCA1; STX8; SNAP23.1; SYT16; PTPN2; SNAP23.2|
PTPN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN2.
GHR; ITGA1; WASL; CDC42; INSR; SFN; UCHL5; q5ni33_fratt; PSMC1; EGFR