ptpn2
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  • Official Full Name
  • protein tyrosine phosphatase, non-receptor type 2
  • Background
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
  • Synonyms
  • PTPN2; protein tyrosine phosphatase, non-receptor type 2; PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP; tyrosine-protein phosphatase non-receptor type 2; T-cell protein tyrosine phosphatase;
Cat.#:PTPN2-3131HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PTPN2 Protein, MYC/DDK-tagged
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Cat.#:PTPN2-2056HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN2, GST-tagged
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Cat.#:PTPN2-470HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTPN2, Gly & Pro tagged
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Cat.#:PTPN2-8088HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN2 protein, His & T7-tagged
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Cat.#:PTPN2-940HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTPN2, His & GST tagged
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Cat.#:Ptpn2-2548MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Ptpn2, His tagged
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Cat.#:Ptpn2-8089MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptpn2 protein, His & T7-tagged
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Cat.#:PTPN2-4831RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTPN2 Protein
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Cat.#:PTPN2-4267CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTPN2
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Cat.#:PTPN2-1519HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN2 (Active), GST-tagged
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Cat.#:PTPN2-464HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTPN2,GST-tagged,Active
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Cat.#:PTPN2-567HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTPN2 cell lysate
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Cat.#:PTPN2-533MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse PTPN2 cell lysate
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Involved Pathway

PTPN2 involved in several pathways and played different roles in them. We selected most pathways PTPN2 participated on our site, such as Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
SOCS5B; GM-CSF; CCND2A; LIFR; RAF1B; PTPN2B; PIAS1; PIK3R3; IL27RA; TSLP

Protein Function

PTPN2 has several biochemical functions, for example, integrin binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN2 itself. We selected most functions PTPN2 had, and list some proteins which have the same functions with PTPN2. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein ICAM1; LAMB1; L1CAM; ADAMTS5; CTGFB; FBLN1; ANGPTL3; ITGA5; WISP3; ICAM3
Function protein binding
Related Protein Ctsl; PLCG1; MSH2; DTX2; MYBPC1; PLXND1; PSMC6; UBE2B; ARHGEF1; CARKD
Function protein kinase binding
Related Protein MAG; BCL10; ADIPOR1; RICTOR; CADPS; CCNT2A; CYLD; NEK9; DNAJC3; CDKN2D
Function protein tyrosine phosphatase activity
Related Protein MTM1; DUSP21; DUSP23; PTPN23A; DUSP8A; DUSP14; PTPRDB; PALD1B; DUSP18; PTPN11B
Function receptor tyrosine kinase binding
Related Protein TOB1; DNAJA3; PTPN14; SOCS5; NRG3; Flt3l; GNB2L1; TP53; ARHGEF16; FLT3LG
Function syntaxin binding
Related Protein VPS54; CPLX3A; RPH3A; CPLX3; STX6; CAV1; SNAP29; NAPAB; CPLX3B; SYT3

Interacting Protein

PTPN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN2.
GHR; ITGA1; WASL; CDC42; INSR; SFN; UCHL5; q5ni33_fratt; PSMC1; EGFR

PTPN2 Related Articles

Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
Li, HJ; Spagnol, G; et al. TC-PTP directly interacts with connexin43 to regulate gap junction intercellular communication. JOURNAL OF CELL SCIENCE 127:3269-3279(2014).