rad51
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  • Official Full Name
  • RAD51 recombinase
  • Background
  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
  • Synonyms
  • RAD51; RAD51 recombinase; RECA; BRCC5; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930; DNA repair protein RAD51 homolog 1; RAD51 homolog A; RecA-like protein; recombination protein A; RecA, E. coli, homolog of; BRCA1/BRCA2-containing complex, subunit 5;
Cat.#:RAD51-1121HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51
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Cat.#:RAD51-128HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51, His-tagged
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Cat.#:RAD51-134HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51
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Cat.#:RAD51-2155HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51, GST-tagged
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Cat.#:RAD51-29580THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51, His-tagged
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Cat.#:RAD51-29581THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAD51
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Cat.#:RAD51-6728CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAD51
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Cat.#:RAD51-12414ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAD51
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Cat.#:RAD51-2556HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RAD51 293 Cell Lysate
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Involved Pathway

RAD51 involved in several pathways and played different roles in them. We selected most pathways RAD51 participated on our site, such as Homologous recombination, Fanconi anemia pathway, Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAD51 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Homologous recombination
TOP3B; RAD54L; BRCA2; CDK5R2; RPA3; XRCC2; NBN; FUZ; MUS81; RAD51
Fanconi anemia pathway
APITD1; EME2; USP1; UBE2T; RPA3; FANCF; BLM; WDR48; RAD51C; PALB2
Pathways in cancer
XIAP; MSH3; COL4A1; LAMA5; FGF11; NFKB1; PDGFRB; FGF13; PTGS2; GNB3
Pancreatic cancer
SMAD4; PIK3CG; BRCA2; MAPK1; PIK3CD; PIK3CA; PIK3R1; ARHGEF6; TGFBR2; NFKB1

Protein Function

RAD51 has several biochemical functions, for example, ATP binding, DNA polymerase binding, chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAD51 itself. We selected most functions RAD51 had, and list some proteins which have the same functions with RAD51. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein TMEM38A; LONP1; CDK2; RIPK4; NTPCR; NWD1; CDK9; TTLL13; DCAMKL2; KIF13B
Function DNA polymerase binding
Related Protein PCNA; FANCI; CDK2AP1; SMARCA4; FANCD2; ACD; LONP1; RAD51; HMGB1
Function chromatin binding
Related Protein SLC30A9; AAAS; POLG; BARX2; DNAJC2; HMGB1; JUB; ACTL6A; JDP2; SMAD2
Function double-stranded DNA binding
Related Protein MTERFD1; XRCC2; ZNF638; RAD51; FEV; CSDA; RAD51AP1; KIN; SMAD2; AFF3
Function contributes_to endodeoxyribonuclease activity
Related Protein XRCC2; RAD51L1; DMC1; RAD51; ERCC4; RAD51L3; RAD51D; RAD51B
Function four-way junction DNA binding
Related Protein MEN1; RAD51; RAD51L1; DMC1; HMGB2; HMGB1; HMGB3; YY1; RAD51L3
Function identical protein binding
Related Protein ERBB3; APIP; TLR3; CEP170L; SERPINA1; ABCD1; G6PDX; GLUL; ACPP; SOD2
Function protein C-terminus binding
Related Protein VIM; ERCC1; OPRL1; MPDZ; PROP1; RABAC1; RAD51; PEX16; PICK1; SLC9A3R2
Function protein binding
Related Protein FYN; ANXA5; UNC13B; RELB; E2F3; EIF4B; SLC22A17; MED7; SIRT1; RPUSD3
Function recombinase activity
Related Protein RAD51D; RBPJ; XRCC2; RAD51L1; RAD51; XRCC3; RAD51B; DMC1; RAD51L3; RAD51C
Function single-stranded DNA binding
Related Protein XPC; RAD51AP1; SSBP3B; XRCC3; XRCC2; TREX1; RPA2; RAD51D; TDP2; SUB1
Function single-stranded DNA-dependent ATPase activity
Related Protein RAD51; DNA2; RAD18

Interacting Protein

RAD51 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAD51 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAD51.
BRCA2

RAD51 Related Articles

Liu, H; Yang, WF; et al. Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. ONCOTARGETS AND THERAPY 8:509-518(2015).
Le Cigne, A; Menil-Philippot, V; et al. Transient expression of RAD51 in the late G2-phase is required for cell cycle progression in synchronous Physarum cells. GENES TO CELLS 19:755-765(2014).