RAF1
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Official Full Name
v-raf-1 murine leukemia viral oncogene homolog 1
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Overview
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008] -
Synonyms
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; RAF proto-oncogene serine/threonine-protein kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; Craf1; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mamanlian cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|MBP
- SUMO
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- 6×His
- C
- FLAG
- The N
- terminal 6XHis
- Avi Tag
- Involved Pathway
- Protein Function
- Interacting Protein
- RAF1 Related Articles
- RAF1 Related Research Area
- RAF1 Related Signal Pathway
RAF1 involved in several pathways and played different roles in them. We selected most pathways RAF1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | TAOK1;IL1R2;MAPKAPK2A;PPP3R2;CDC25B;RELA;CACNA1G;JUND;CACNB2A |
| ErbB signaling pathway | PRKCA;MAP2K4A;PAK4;NCK1;EGFRA;MAP2K4;CAMK2B1;AKT2;ERBB3B |
| Ras signaling pathway | RASGRP3;RASAL2;GNG13;GRIN2A;RASSF1;FGF20;RAB5B;PRKCG;ELK1 |
| Rap signaling pathway | FIGF;ITGA2B;SIPA1L2;GRIN1;FGF14;MAGI1;INS1;LPAR4;PDGFRA |
| cGMP-PKG signaling pathway | PPP3CC;VASP;BAD;PIK3R3;ITPR3;MAPK1;NPPB;ATP1B2;INS2 |
| cAMP signaling pathway | BRAF;GABBR1;CREB3L1;RAP1B;PPARA;PDE3B;HCN2;TNNI3;CNGA1 |
| Chemokine signaling pathway | AKT1;GNG4;NCF1;CCL2;CRK;RAP1B;HCK;PLCB3;LOC100033925 |
| FoxO signaling pathway | PIK3R3B;PRKAA1;STK4;FOXO1B;PLK2B;MAPK11;EGFRA;GABARAPA;CCND2A |
| Sphingolipid signaling pathway | TNFRSF1A;FCER1A;SGMS2;BAX;ASAH1;NFKB1;PLD2;S1PR2;TP53 |
| Phospholipase D signaling pathway | MAPK1;AVPR1A;PLCB3;INS;MTOR;PPAP2C;FCER1G;LPAR5;GRM4 |
| PIK-Akt signaling pathway | IL2RG;ITGB7;G6PC;YWHAZ;GNG2;Il6ra;TCL1A;PPP2R3C;PRKCA |
| Vascular smooth muscle contraction | PPP1R14AB;ACTG2;RHOAD;MYH11;PLA2G12A;PLA2G2D;PRKCD;CALML5;GUCY1B3 |
| VEGF signaling pathway | PTK2AB;MAPKAPK2;AKT2L;PTGS2;VEGFAB;AKT1;PPP3CA;NRAS;HSPB1 |
| Focal adhesion | PDPK1;RAP1A;PARVB;ITGA9;COL11A2;THBS1;ACTB2;MYLPFA;MAP2K1 |
| Gap junction | PRKACG;ADCY1B;GNAQ;GUCY1B3;CDK1;DRD1A;MAP2K2;ADCY1A;Adcy4 |
| Signaling pathways regulating pluripotency of stem cells | LIF;FZD7;MEIS1;AKT2;REST;FZD3;WNT3A;SMAD1;MAP2K2 |
| Jak-STAT signaling pathway | PIK3R5;MPL;IL23R;EPOR;PRL2;PTPN11B;PIK3R2;IL23;JAK2B |
| Natural killer cell mediated cytotoxicity | H60a;NCR2;ZAP70;IFNB1;ICAM2;SH3BP2;PPP3R1;ULBP3;LCP2 |
| T cell receptor signaling pathway | NFKBIA;RAF1;NRAS;PIK3CB;PTPN6;HRAS;NFKB1;CD3E;PAK2 |
| B cell receptor signaling pathway | HDAC5;PDK2B;STAP1;RAC1;FOS;BTK;LIME1;PIK3R3;NEDD9 |
| Fc epsilon RI signaling pathway | RAC2;MAPK13;PIK3CA;AKT2;MAPK10;LCP2;PIK3R5;MAP2K7;HRAS |
| Fc gamma R-mediated phagocytosis | MAPK3;PLD1;PRKCB;PRKCG;PIK3R2;ASAP2;PPAP2A;WASF2;GSN |
| Long-term potentiation | PRKCA;MAPK3;MAPK1;CAMK2A;GRIA1;RPS6KA1;CALML5;PLCB3;PLCB1 |
| Neurotrophin signaling pathway | RIPK2;MAPK12;PSEN2;FASLG;MAP3K3;FOXO3;ABL1;ARHGDIB;MAPK11 |
| Serotonergic synapse | PLA2G4A;GNG3;HTR1F;CYP2D9;PRKCG;SLC18A1;CYP2C50;HTR1A;GNAO1 |
| Long-term depression | GUCY1A3;RYR1;PLA2G4D;PLCB3;GNA13;PRKCA;PLCB1;ITPR3;BRAF |
| Regulation of actin cytoskeleton | FGF17;VCL;FGF10;CYFIP1;MYLK;ITGA5;FN1;ITGB2;ABI2A |
| Insulin signaling pathway | RAF1A;IKBKB;PRKACBA;PHKB;PHKG1A;PRKAB1B;PRKAG3;PPARGC1A;CALM2 |
| GnRH signaling pathway | CALM1;ITPR3;PRKCA;PRKACBB;PRKCBB;SOS1;ADCY1B;PLD1;PLD1A |
| Progesterone-mediated oocyte maturation | MAPK12;SPDYA;RPS6KA2;PRKACG;CDC25B;CPEB2;CPEB1B;FZR1;PIK3CB |
| Estrogen signaling pathway | PIK3CB;Adcy4;PIK3R2;FKBP5;MAPK1;PIK3R5;AKT1;MMP9;GABBR2 |
| Melanogenesis | CAMK2B1;DCT;ADCY1A;GNA15.1;CREB3L1;KITLGB;CAMK2A;WNT9A;PRKACG |
| Prolactin signaling pathway | GSK3B;SIRPA;GRB2;PIK3CA;FOXO3;SOCS5;GALT;SHC3;PRLR |
| Thyroid hormone signaling pathway | PIK3R3;TBC1D4;NOTCH2;PRKCG;PLCG2;PIK3R1;PIK3R5;MED4;MED24 |
| Oxytocin signaling pathway | PLA2G4A;PRKACA;PPP3CB;NOS3;CAMK2D;NRAS;PIK3R5;TRPM2;PRKAA2 |
| Alcoholism | HIST1H2AG;GM14478;MAPK3;HIST1H2AD;HIST2H3A;GNAS;H2AFV;HIST2H3C2;ADORA2A |
| Tuberculosis | FCGR3;IFNA14;HLA-DPB1;CASP9;ATP6V1H;SRC;CASP8;C3;RAB7A |
| Hepatitis C | MAPK11;MAPK8;IFNA2;PIK3R2;TRAF3;PIK3CD;CLDN6;RAF1;PPP2CB |
| Hepatitis B | SRC;STAT4;AKT1;BIRC5;NFATC2;STAT5A;STAT6;IL6;MAP2K4 |
| Influenza A | FURIN;TRIM25;TMPRSS13;MAPK1;PIK3CG;PLG;FAS;NLRP3;HLA-DRB5 |
| Pathways in cancer | CYCS;TRP53;PIK3R2;TCEB2;LPAR3;ITGA2B;PTCH1;MSH3;FGF20 |
| Proteoglycans in cancer | BRAF;FZD7;RDX;RRAS;WNT7A;CAMK2D;CAMK2A;NRAS;WNT8B |
| MicroRNAs in cancer | FOXP1;ABCC1;TNN;RAF1;DNMT3A;SIRT1;WNT3;APC2;DICER1 |
| Colorectal cancer | AKT2;APC;PIK3R2;FOS;BCL2;BAX;PIK3R5;MSH3;AXIN2 |
| Renal cell carcinoma | FH1;RAF1;GAB1;MAPK1;ARAF;HGF;MAP2K1;GRB2;TGFB1 |
| Pancreatic cancer | MAPK3;TGFA;TRP53;TGFBR2;RALBP1;IKBKB;CASP9;PIK3CA;AKT2 |
| Endometrial cancer | GSK3B;CTNNA2;AKT1;ERBB2;PIK3R2;CDH1;MAP2K1;APC;MLH1 |
| Glioma | CALML5;CALM3;CCND1;HRAS;KRAS;SHC3;MDM2;PIK3R2;IGF1 |
| Prostate cancer | IGF1;CASP9;PIK3R5;RELA;CREB3L2;PIK3CB;SMARCC2;HSP90AB1;NDRG1 |
| Melanoma | FGF22;PIK3CA;MET;FGF19;FGF4;CDH1;PIK3R5;MAP2K2;ARAF |
| Bladder cancer | MAPK3;RASSF1;ERBB2;THBS1;E2F3;RPS6KA5;FGFR3;DAPK3;MAP2K1 |
| Chronic myeloid leukemia | PIK3CB;RELA;MAP2K2;SOS1;IKBKB;TRP53;RB1;IKBKG;NFKB1 |
| Acute myeloid leukemia | MAP2K1;HRAS;NRAS;PIK3CA;PIM2;AKT2;SOS1;TCF7L2;PIK3CD |
| Non-small cell lung cancer | PIK3CD;GRB2;PRKCA;PIK3CA;ARAF;MAPK1;BRAF;RXRA;PRKCG |
| Central carbon metabolism in cancer | G6PDX;ERBB2;HRAS;SLC7A5;NTRK1;PIK3CB;PIK3R2;PFKP;MET |
| Choline metabolism in cancer | PIK3R2;WAS;GRB2;SOS1;RHEB;WASF1;PRKCB;DGKQ;PPAP2A |
RAF1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAF1 itself. We selected most functions RAF1 had, and list some proteins which have the same functions with RAF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIT;ZNF143B;CKBA;PSMC1B;CCC2;PRPS2;OASL1;ERBB3B;PIK3C2A |
| MAP kinase kinase kinase activity | MAP3K2;MAP3K14;STK4;EGFR;YSK4;BRAF;MAP3K12;MAP3K5;MOS |
| identical protein binding | ATXN10;NME1;HCN2;CEP72;APLP1;CBLL1;ATF3;PRDX1;SLC2A1 |
| metal ion binding | XIRP2;BTR16;DNAJA2;ATP8B1;TRIM41;SLX1B;TNNC1;MDP1;PHOSPHO2 |
| mitogen-activated protein kinase kinase binding | MAPK8IP3;ACE;KSR1;IGBP1;TAOK2;PIN1;ARRB1;TRIB2;MAP3K11 |
| protein binding | SULT2A1;KRTAP12-2;CDK4;MEI4;LACE1;AXIN1;NBN;FZD3;AGO1 |
| protein heterodimerization activity | TAF6L;HIST2H4A;HIST1H2AB;SOX9;HIST3H3;HGF;HIST2H2AC;ATF6;SOX5 |
| protein kinase activity | GM711;NEK5;MMD2;IGF1RB;NRBP1;PIK3CG;NPR1A;ZNF143B;NLK |
| protein serine/threonine kinase activity | TSSK5;CLK1;IKBKB;RIPK4;CHEK2;MAP3K2;STK10;BMPR1A;RIOK3 |
| NOT small GTPase binding | BRAF;RAF1 |
RAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAF1.
HRAS; YWHAZ
- Q&As
- Reviews
Q&As (5)
Ask a questionThe RAF1 protein is studied through a combination of molecular biology techniques, such as immunohistochemistry, Western blotting, and genetic sequencing, in both clinical and research settings.
RAF1 protein expression is not typically included in routine cancer diagnostics. Instead, mutations and expression levels of other genes, like BRAF, are often analyzed in cancer patients.
Clinical trials involving RAF1 protein are ongoing for conditions like Noonan syndrome and certain cancers. These trials aim to develop new therapies and better understand its role in disease.
RAF1 mutations can affect cardiac development, leading to congenital heart defects and other cardiac issues in patients with Noonan syndrome. This has important clinical implications for cardiologists and genetic counselors.
Yes, RAF1 mutations can be inherited, and they can lead to Noonan syndrome. This can have a significant impact on affected individuals and their families, necessitating specialized medical care and genetic counseling.
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