raf1
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  • Official Full Name
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • Background
  • This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RAF1; v-raf-1 murine leukemia viral oncogene homolog 1; NS5; CRAF; Raf-1; c-Raf; RAF proto-oncogene serine/threonine-protein kinase; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; Craf1; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik
Cat.#:RAF1-1123HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAF1 Protein, GST-tagged
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Cat.#:RAF1-413HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RAF1 Protein (Ser306-Phe648), His-GST-tagged
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Cat.#:RAF1-428HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAF1 Protein, His-tagged
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Cat.#:RAF1-442HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RAF1 Protein, His-tagged
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Cat.#:RAF1-1122HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human V-raf-1 Murine Leukemia Viral Oncogene Homolog 1
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Cat.#:RAF1-169HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RAF1 protein, His-tagged
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Cat.#:RAF1-16HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RAF1, GST-tagged
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Cat.#:RAF1-2161HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAF1, GST-tagged
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Cat.#:RAF1-29370THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAF1
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Cat.#:RAF1-305HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RAF1
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Cat.#:RAF1-352HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAF1 protein, His/MBP-tagged
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Cat.#:RAF1-416HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human RAF1 protein, GST-tagged
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Cat.#:RAF1-551HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RAF1, GST-tagged
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Cat.#:RAF1-552HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RAF1, MYC/DDK-tagged
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Cat.#:RAF1-553HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RAF1, GST-tagged
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Cat.#:RAF1-13888MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RAF1 Protein
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Cat.#:RAF1-4913RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAF1 Protein
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Cat.#:RAF1-3775RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RAF1 Protein, His-tagged
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Cat.#:RAF1-6859CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAF1
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Cat.#:RAF1-1463HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RAF1 cell lysate
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Involved Pathway

RAF1 involved in several pathways and played different roles in them. We selected most pathways RAF1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG6A; PLA2G4F; TRAF2; MKNK2A; FGFR1; RPS6KA3A; NRAS; EGFRA; KRAS; CACNA1C
ErbB signaling pathway
ARAF; MAP2K2; RAF1; RAF1A; KRAS; CDKN1BB; PIK3CA; ERBB2; CBL; PIK3CD
Ras signaling pathway
PLA2G2A; MRAS; ABL1; FGF17; RAB5C; BCL2L1; FGFR2; PAK2; MAPK1; PLCG2
Rap signaling pathway
PLCB3; CALM1; INS; KRAS; INS2; PLCB4; MRAS; INS1; PIK3R3; LPAR5
cGMP-PKG signaling pathway
ATP2A3; PLCB1; BNP; MEF2A; NFATC1; PRKCE; PPP3CA; PPP3R2; VDAC2; PLCB2
cAMP signaling pathway
HTR6; VAV1; PPP1CB; FXYD1; ATP2B4; PIK3CG; ATP1B2; PLD1; ATP1B4; HCN4
Chemokine signaling pathway
SHC4; CX3CL1; PIK3CD; RASGRP2; CXCR2; FOXO3; Ccl27a; Cxcl15; GRB2; GNAI3
FoxO signaling pathway
NLK1; TGFB1A; PLK1; G6PCA.1; PRKAB1B; GABARAPL1; S1PR4; MAP2K2B; RAF1B; MAPK12
Sphingolipid signaling pathway
TRP53; PTEN; CERS4; PPP2R5B; TNF; PIK3CD; NOS3; PLCB3; MAPK11; ROCK2
Phospholipase D signaling pathway
AGTR1A; MAPK1; PIP5K1A; GRM4; SHC3; FYN; PTPN11; CXCR1; PLA2G4D; DGKZ
PIK-Akt signaling pathway
PPP2R3C; PRL; TSC2; TNC; NR4A1; IL2RB; ITGB6; IFNB1; PPP2R2B; RHEB
Vascular smooth muscle contraction
KCNMB4; NPR1A; ADCY2B; GNA12; PRKCG; PRKCDA; KCNMB1; MAP2K2; ITPR3; MAPK3
VEGF signaling pathway
PIK3R2; RAC3; MAPK3; HRAS; MAP2K2; RAF1; PTK2AA; PPP3R2; RAC1B; RAC3A
Focal adhesion
CAPN2L; COL5A2; ACTG1; GRB2A; ITGA4; RAC1A; PTK2; PPP1CC; ITGB1B.2; MAP2K1
Gap junction
TUBA8L4; TUBB1; PDGFAA; PDGFB; SRC; GRM1; PRKACBA; ITPR3; PRKCG; TUBA8L
Signaling pathways regulating pluripotency of stem cells
FZD3; SMARCAD1; FGFR1; IL6ST; MAPK3; JARID2; AKT2; FZD8; TCF3; ISL1
Jak-STAT signaling pathway
CISH; IL2RG; PRL; IL12RB1; NT5C3; IL12A; IL9R; IFNK; HRASA; RNF207B
Natural killer cell mediated cytotoxicity
ICAM1; FCGR3B; KLRC1; IFNA2; NRAS; Ifna11; KIR2DS4; PIK3CD; KIR2DS2; MAPK1
T cell receptor signaling pathway
NFKBIA; EVLB; PIK3CG; PAK1; CD4; NFKB1; IKBKB; PIK3R5; NRAS; NFKBIB
B cell receptor signaling pathway
PILRB; PIK3R1; GSK3AB; RAC1; IGHM; CRKL; PDK2B; PPP3CC; ARPC3; DOK1
Fc epsilon RI signaling pathway
GM-CSF; MAPK11; FYN; PLCG2; MAPK1; INPP5D; IL5; PLA2G4C; MAPK12; GRB2
Fc gamma R-mediated phagocytosis
PLD2; ASAP3; MAPK3; ASAP1; SCIN; VAV1; AKT2; PIK3R1; PLA2G4A; CFL1
Long-term potentiation
PPP1CA; PLCB3; CALM3; PPP1CB; PLCB1; RPS6KA6; CALML3; GRIN2B; CALML5; PRKCA
Neurotrophin signaling pathway
PRKCD; RPS6KA1; ZFP110; PIK3CG; CAMK4; PIK3CB; NGF; CALML3; ARHGDIA; AKT2
Serotonergic synapse
GNGT2; GNGT1; HTR6; PTGS2; GNB3; PTGS1; HTR1E; HTR5A; HTR7; RAF1
Long-term depression
PRKCG; PPP1R17; BRAF; GNA11; GNA13; GUCY1B3; PPP2R1A; NRAS; GUCY1A3; PPP2R1B
Regulation of actin cytoskeleton
IQGAP2; ITGA6B; RRAS2; ACTN2; ITGA6; ITGA11A; SOS1; NCKAP1L; MYH9; ITGA9
Insulin signaling pathway
PRKAR1AB; GYS1; PRKACBA; INS1; PPP1CC; FLOT1A; SOCS4; IRS2; PYGB; PIK3CA
GnRH signaling pathway
GRB2A; MAPK14B; PRKCBA; PLA2G4AA; MAPK8B; MAP3K3; PRKACG; GNA15.1; MMP14B; CALM3
Progesterone-mediated oocyte maturation
IGF1R; MAD2L2; GNAI1; GNAI2; MAPK3; RPS6KA1; RPS6KA6; PIK3CA; ARAF; AKT3A
Estrogen signaling pathway
FKBP4; PIK3CG; AKT2; FOS; CALM3; SHC3; PIK3R5; ITPR1; MMP9; FKBP5
Melanogenesis
WNT7AA; CREB1A; GNA15.1; TYR; GNAS; TCF7; WNT11B; CREB3L3A; MAP2K2; MITF
Prolactin signaling pathway
PIK3R5; CSH; MAP2K1; PRLR; INS2; AKT2; KRAS; CSN2; RAF1; HRAS
Thyroid hormone signaling pathway
SLC9A1; ACTB; MED17; SLC16A10; MED30; RXRA; PFKP; NOTCH4; NOTCH1; ATP1A4
Oxytocin signaling pathway
PIK3CA; GNAQ; CACNG7; PLA2G4D; CAMK2A; MYL6B; CACNG1; CAMK1D; KRAS; MAP2K5
Alcoholism
HIST2H3C2; HIST1H3F; HIST1H2BB; HIST1H2BH; SLC6A3; RAF1; HIST1H4F; H2AFZ; PDYN; SLC18A2
Tuberculosis
Il23a; TLR4; CAMP; H2-AA; NFYC; PIK3C3; ITGAM; LBP; TNFRSF1A; MRC1
Hepatitis C
CLDN8; TNF; CLDN20; PPP2CB; IFNA7; ARAF; EIF3E; IKBKG; PPP2CA; PIK3R1
Hepatitis B
CCND1; PIK3CB; BCL2; MMP9; IFNA6; BAX; IFIH1; STAT2; CXCL8; TGFB2
Influenza A
XPO1; TMPRSS13; TBK1; HLA-DMB; IL8L2; PIK3CG; DDX39B; BLB1; CCL5; HSPA1L
Pathways in cancer
GNG7; GNG8; TP53; FGF2; PIK3CG; Fgf15; WNT7B; RAC1; LAMB3; FZD10
Proteoglycans in cancer
PTCH1; FZD3; AKT1; FZD9; PIK3R1; WNT8A; MAPK13; FN1; RAC1; FZD2
MicroRNAs in cancer
PRKCA; SOS1; HOXD10; BMPR2; PRKCE; PTEN; DICER1; RPS6KA5; CDC25A; SHC1
Colorectal cancer
AKT2; APC; PIK3CG; AKT1; TGFB3; BRAF; PIK3CD; ARAF; MAPK1; SMAD2
Renal cell carcinoma
ETS1; NRAS; ARNT; TGFB1; HRAS; KRAS; PAK6; PDGFB; CUL2; FH
Pancreatic cancer
PIK3R2; ARAF; CASP9; BRAF; RALBP1; SMAD2; TGFBR1; BAD; RB1; PLD1
Endometrial cancer
RAF1; PIK3R5; PDPK1; TP53; HRAS; MAP2K2; ARAF; GRB2; PIK3CB; BAD
Glioma
PRKCA; PIK3R2; PLCG1; IGF1R; CAMK2B; RAF1; CAMK2G; CALM1; Pdgfa&Pdgfb; CAMK2A
Prostate cancer
SPRY1; INS1; CREB3L3; FGFR1; AKT1; TCF7; ACTL6B; GSTP1; PIK3CB; INSRR
Melanoma
AKT1; FGF18; BRAF; FGF17; MAP2K2; FGF20; FGF4; FGF3; PDGFD; FGF6
Bladder cancer
TRP53; MMP9; E2F1; THBS1; HBEGF; TP53; RAF1; SRC; TYMP; UPK3A
Chronic myeloid leukemia
GAB2; RELA; SHC3; RUNX1; MAP2K1; PIK3R1; SMAD4; STAT5A; PIK3CB; TRP53
Acute myeloid leukemia
RUNX1T1; NRAS; MAPK3; BRAF; PIM1; RARA; MAPK1; AKT3; PIK3CG; KRAS
Non-small cell lung cancer
TGFA; STK4; PIK3R3; PRKCB; PLCG2; AKT1; MAP2K2; GRB2; PLCG1; RAF1
Central carbon metabolism in cancer
TRP53; SIRT6; NTRK1; HRAS; GLS; PIK3R1; PDHB; KRAS; FGFR2; PDGFRB
Choline metabolism in cancer
DGKZ; PRKCB; PLCG1; AKT1; PPAP2B; PRKCG; PLA2G4A; PDGFB; MAPK10; SLC5A7

Protein Function

RAF1 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RAF1 itself. We selected most functions RAF1 had, and list some proteins which have the same functions with RAF1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCG3; NLRC5; ABCF2A; YRK; KDRL; PFKMB; SPG7; ABCC11; ADCK1; LCK
Function MAP kinase kinase kinase activity
Related Protein TAOK1; MAP3K13; KIAA1804; MAP3K5; ALPK2; MAP3K2; EGFR; MAP3K15; TAOK3; MAP3K4
Function identical protein binding
Related Protein ENTPD2; RAD51; GRB2; FADD; CAD; C; KHDC1B; UHRF1; NDE1; GBP1
Function metal ion binding
Related Protein ZFP385C; CYP46A1.4; CNOT8; DPYD; ADSSL; ZFP518A; HNRNPA0L; ARMC1; DNTT; ZNF680
Function mitogen-activated protein kinase kinase binding
Related Protein TRIB3; ACE; ARRB1; RAF1; MAPK8IP3; PIN1; KSR1; MAP3K11; TAOK2; IGBP1
Function protein binding
Related Protein ZFP57; PRC1; IFITM1; FAM168A; EP400; GORAB; PLIN3; MOB4; RCAN1; NPPB
Function protein heterodimerization activity
Related Protein TENM1; HIST1H4A; CYBB; ENO2; ATF3; ADORA1; EPAS1; KATNB1; TRP53; SLC3A1
Function protein kinase activity
Related Protein TEK; CSNK1DA; CCL8; SNRKA; CDK8; PKN1; PDK3; WEE2; PRKCHA; NPR1
Function protein serine/threonine kinase activity
Related Protein PKZ; CHEK2; CSNK1D; ULK1; PHKG2; STRC; DYRK4; TNK2; NLK2; NEK1
Function NOT small GTPase binding
Related Protein RAF1; BRAF

Interacting Protein

RAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAF1.
HRAS; YWHAZ

RAF1 Related Articles

Feiz, L; Williams-Carrier, R; et al. A protein with an inactive pterin-4a-carbinolamine dehydratase domain is required for Rubisco biogenesis in plants. PLANT JOURNAL 80:862-869(2014).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).