sirt5
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  • Official Full Name
  • sirtuin 5
  • Background
  • Sirtuin family of proteins that is important in aging, metabolism and disease. SIRT5 is expressed in a variety of tissues. Two different isoform have been described. Isoform 1 is reported to be express in the mitochondria and cytoplasm while isoform 2 appears to be localized to the mitochondria only. SIRT5 has also been linked to many primate-specific functions. SIRT5 has recently been implicated as having a role in adaptation to fasting, caloric restriction and high protein diets.
  • Synonyms
  • SIRT5; sirtuin 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; sir2-like 5; sirtuin type 5; SIR2-like protein 5; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; SIR2L5; FLJ36950
Cat.#:SIRT5-677HTag:FLAG
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT5 Protein (Arg2-Ser310), FLAG-tagged
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Cat.#:SIRT5-192HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SIRT5 Protein, His-tagged
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Cat.#:SIRT5-2434HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human SIRT5, His-tagged
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Cat.#:SIRT5-2683HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT5, His-tagged
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Cat.#:SIRT5-31167THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT5
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Cat.#:SIRT5-342HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT5
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Cat.#:SIRT5-4880HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 5, His-tagged
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Cat.#:SIRT5-4881HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 5, GST-tagged
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Cat.#:Sirt5-1379MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirt5 protein, His-tagged
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Cat.#:SIRT5-15155MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SIRT5 Protein
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Cat.#:Sirt5-1380RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt5 protein, His-tagged
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Cat.#:SIRT5-5409RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SIRT5 Protein
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Cat.#:SIRT5-4712CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT5
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Cat.#:SIRT5-720ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIRT5
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Cat.#:SIRT5-1830HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT5 293 Cell Lysate
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Involved Pathway

SIRT5 involved in several pathways and played different roles in them. We selected most pathways SIRT5 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling events mediated by HDAC Class I
NR2C1; FKBP3; GATA1; SIRT4; TFCP2; SIRT5; PRMT5; SIRT7; SIRT2; WDR77

Protein Function

SIRT5 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, protein-glutaryllysine deglutarylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT5 itself. We selected most functions SIRT5 had, and list some proteins which have the same functions with SIRT5. You can find most of the proteins on our site.
Function
Related Protein
Function NOT NAD+ ADP-ribosyltransferase activity
Related Protein SIRT1; SIRT5; SIRT3; SIRT2
Function NAD+ binding
Related Protein SIRT5; SIRT4; UXS1; HADH; SIRT1; SIRT3; SIRT6; SIRT2; ALDH1A3; HPGD
Function protein-glutaryllysine deglutarylase activity
Related Protein SIRT5
Function protein-malonyllysine demalonylase activity
Related Protein SIRT5
Function protein-succinyllysine desuccinylase activity
Related Protein SIRT5
Function zinc ion binding
Related Protein Car2; ADAM33; JUB; OTUD7A; TRIML1; MMP10; MMP11; CDADC1; ADAM8; TRIM21

Interacting Protein

SIRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT5.
MYC; BAG6; HNRNPD; SGTB; SORT1