SIRT5 Protein, sirtuin 5


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Official Full Name sirtuin 5
Background Sirtuin family of proteins that is important in aging, metabolism and disease. SIRT5 is expressed in a variety of tissues. Two different isoform have been described. Isoform 1 is reported to be express in the mitochondria and cytoplasm while isoform 2 appears to be localized to the mitochondria only. SIRT5 has also been linked to many primate-specific functions. SIRT5 has recently been implicated as having a role in adaptation to fasting, caloric restriction and high protein diets.
Synonyms SIRT5; sirtuin 5; sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5; NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; sir2-like 5; sirtuin type 5; SIR2-like protein 5; NAD-dependent deacetylase sirtuin-5; silent mating type information regulation 2, S.cerevisiae, homolog 5; SIR2L5; FLJ36950
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • FLAG
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SIRT5-25H Recombinant Human SIRT5 Protein, GST-tagged E.coli GST
    Human SIRT5-677H Recombinant Human SIRT5 Protein (Arg2-Ser310), FLAG-tagged E.coli FLAG
    Human SIRT5-1830HCL Recombinant Human SIRT5 293 Cell Lysate HEK293 N/A
    Human SIRT5-192H Recombinant Human SIRT5 Protein, His-tagged E.coli His
    Human SIRT5-2434H Recombinant human SIRT5, His-tagged E.coli His
    Human SIRT5-2683H Recombinant Human SIRT5, His-tagged E.coli His
    Human SIRT5-31167TH Recombinant Human SIRT5 E.coli N/A
    Human SIRT5-342H Recombinant Human SIRT5 E.coli N/A
    Human SIRT5-4880H Recombinant Human Sirtuin 5, His-tagged Sf9 Insect Cell His
    Human SIRT5-4881H Recombinant Human Sirtuin 5, GST-tagged E.coli GST
    Mouse Sirt5-1379M Recombinant Mouse Sirt5 protein, His-tagged E.coli His
    Mouse SIRT5-15155M Recombinant Mouse SIRT5 Protein Mammalian Cell His
    Rat Sirt5-1380R Recombinant Rat Sirt5 protein, His-tagged E.coli His
    Rat SIRT5-5409R Recombinant Rat SIRT5 Protein Mammalian Cell His
    Chicken SIRT5-4712C Recombinant Chicken SIRT5 Mammalian Cell His
    Zebrafish SIRT5-720Z Recombinant Zebrafish SIRT5 Mammalian Cell His

    SIRT5 involved in several pathways and played different roles in them. We selected most pathways SIRT5 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling events mediated by HDAC Class I GATA1; SIRT5; MXD1; PRMT5; TFCP2; FKBP3; WDR77; GATA2; SIRT4; NR2C1

    SIRT5 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding, protein-glutaryllysine deglutarylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT5 itself. We selected most functions SIRT5 had, and list some proteins which have the same functions with SIRT5. You can find most of the proteins on our site.

    Function Related Protein
    NOT NAD+ ADP-ribosyltransferase activity SIRT1; SIRT2; SIRT5; SIRT3
    protein-glutaryllysine deglutarylase activity SIRT5
    protein-malonyllysine demalonylase activity SIRT5
    protein-succinyllysine desuccinylase activity SIRT5
    zinc ion binding RNF20; PJA2; APOBEC3H; CAHZ; NR1H5; ZPR1; ADAMTSL1; ERAP2; BTR02; CA1

    SIRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT5.


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