smad1
Share
  • Official Full Name
  • SMAD family member 1
  • Background
  • The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;
Cat.#:SMAD1-1916HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1 Protein, His-tagged
+Inquiry
Cat.#:SMAD1-11HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1, His-tagged
+Inquiry
Cat.#:SMAD1-12HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SMAD1, MYC/DDK-tagged
+Inquiry
Cat.#:SMAD1-160HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1 Protein, His-tagged
+Inquiry
Cat.#:SMAD1-161HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1 Protein, His-tagged
+Inquiry
Cat.#:SMAD1-2799HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1, GST-tagged
+Inquiry
Cat.#:SMAD1-30445THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1
+Inquiry
Cat.#:SMAD1-43HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD1 protein, GST-tagged
+Inquiry
Cat.#:SMAD1-15584MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SMAD1 Protein
+Inquiry
Cat.#:Smad1-657MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Smad1 protein, His & T7-tagged
+Inquiry
Cat.#:Smad1-658RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Smad1 protein, His-tagged
+Inquiry
Cat.#:SMAD1-4329RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SMAD1 Protein, His-tagged
+Inquiry
Cat.#:SMAD1-4493CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SMAD1
+Inquiry
Cat.#:SMAD1-8936ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SMAD1
+Inquiry
Cat.#:SMAD1-656CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle SMAD1 protein, His & T7-tagged
+Inquiry
Cat.#:SMAD1-1092HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SMAD Family Member 1, GST-tagged
+Inquiry
Cat.#:SMAD1-1677HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SMAD1 293 Cell Lysate
+Inquiry
Cat.#:SMAD1-1678HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SMAD1 293 Cell Lysate
+Inquiry

Involved Pathway

SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
INHBAB; BMP2; INHBA; TGFB2; BMP2B; ID4; TGFBR2; RHOAB; BAMBI; TGFBR1B
Hippo signaling pathway
BMP8A; INADL; WNT9A; WNT9B; BMP5; FGF1; WNT1; CCND3; CRB2; PPP2R2B
Signaling pathways regulating pluripotency of stem cells
PIK3CB; PIK3R5; WNT9A; APC; ID1; FGFR2; PCGF6; SMAD1; PIK3CA; ZFHX3
Transcriptional misregulation in cancer
RARA; TGFBR2; Aff1; ZEB1; SUPT3H; ELANE; Pdgfa&Pdgfb; PAX3; RELA; MAX

Protein Function

SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.
Function
Related Protein
Function I-SMAD binding
Related Protein SMAD6; CTNNB1; TGFB1I1; SMAD4; SMAD1; SMURF1; SMAD7; AXIN2; SMAD2; AXIN1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NEUROD6; HINFP; ZNF264; PPARA; ETV2; MITF; SIX4; KLF16; ETV6; BATF3
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein SPI1; ZNF277; GATA6; NR4A2; PAX6; RREB1; ZNF335; HEYL; HOXB3; PAX8
Function co-SMAD binding
Related Protein SMAD3; CITED1; FOXH1; TGIF1; SMAD2; GATA4; SMAD6; USP9X; SMAD1; TRIM33
Function identical protein binding
Related Protein ABCD1; SELK; EPOR; SERPINA1D; S100A1; HAND2; RELA; RNF4; MAP1S; DACT3
Function metal ion binding
Related Protein ISL2B; CAHZ; GALNT5; TGM2B; ZNF878; ZNF23; TRIM50; GLI4; SDHD; ZBTB8OS
Function protein binding
Related Protein HESX1; BAP1; CDC42SE2; GJD3; GRHL3; LDLR; DCDC2; CXCL11; HTT; E2F6
Function protein heterodimerization activity
Related Protein MCL1A; MEF2C; VEGFB; PIK3R1; Bcl2a1b; UNC13A; HIST1H2BA; SOX17; TAF6L; ITGB1
Function protein homodimerization activity
Related Protein TERFA; LCN2; NCR3; NR4A2; BAXA; P2RX7; PON1; NOG; SDCBP2; NUDT21
Function protein kinase binding
Related Protein ERRFI1; ATG13; CEP68; CACNB4; NEFH; ADIPOR1; MAP3K2; USF1; CACNB2; CCND3
Function receptor signaling protein activity
Related Protein BAG4; RGS12; PDCL; FCGR1A; TGFBR1; RGS14; TRAIP; ARAF; IL4R; IL1RL1
Function transcription factor activity, sequence-specific DNA binding
Related Protein IRF9; GTF2IRD1; FOXJ1B; SIM1; POU4F2; SMAD7; TRERF1; SLC26A3; ZNF286A; MGAA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein PLSCR1; OTX2; CEBPG; NPAS4; ELF3; PPARA; SOX11; YBX1; EGR1; NOBOX
Function transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
Related Protein SMAD9; SMAD1; SMAD3; SMAD2

Interacting Protein

SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.
SMAD4; GSK3B; AR

SMAD1 Related Articles

Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).

SMAD1 Related Gene Family

TGF