SMAD1
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Official Full Name
SMAD family member 1
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Overview
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008] -
Synonyms
SMAD1; SMAD family member 1; BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1; mothers against decapentaplegic homolog 1; MAD homolog 1; Mad-related protein 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; SMAD, mothers against DPP homolog 1; MAD, mothers against decapentaplegic homolog 1; transforming growth factor-beta signaling protein 1; transforming growth factor-beta-signaling protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SMAD1 Related Articles
- SMAD1 Related Gene Family
- SMAD1 Related Research Area
- SMAD1 Related Signal Pathway
SMAD1 involved in several pathways and played different roles in them. We selected most pathways SMAD1 participated on our site, such as TGF-beta signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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TGF-beta signaling pathway | INHBAB;TGFB1;BMPR1AA;SPAW;IFNG1-2;TFDP1A;RBL1;ID4;BMP2 |
Hippo signaling pathway | WNT3;WWTR1;STK3;WNT11;SMAD7;WNT5B;PPP1CC;CRB1;PARD6B |
Signaling pathways regulating pluripotency of stem cells | PAX6;ZFHX3;WNT4;TBX3;WNT3;BMP4;INHBC;WNT2B;FGFR2 |
Transcriptional misregulation in cancer | MEIS1;NFKB1;TMPRSS2;HIST1H3A;IGF1;RELA;NGFR;IL-8;ETV5 |
SMAD1 has several biochemical functions, for example, I-SMAD binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD1 itself. We selected most functions SMAD1 had, and list some proteins which have the same functions with SMAD1. You can find most of the proteins on our site.
Function | Related Protein |
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I-SMAD binding | SMAD4;SMAD1;SMURF1;TGFB1I1;SMAD7;AXIN1;SMAD6;AXIN2;TGFBR1 |
RNA polymerase II core promoter proximal region sequence-specific DNA binding | PYDC3;TFAP4;EBF1;RBPJ;DDN;ZGPAT;ZBTB7A;TCF4;ASCL2 |
RNA polymerase II core promoter sequence-specific DNA binding | SP1;TP53;WBP2;ZNF277;H3F3B;NSD1;TRP53;MITF;ZFPM1 |
co-SMAD binding | SMAD6;TRIM33;FOXH1;GATA4;SMAD3;TGIF1;SMAD1;SMAD2;USP9X |
identical protein binding | SERPINA1;DNM1L;TK1;BAK1;ADIPOQ;DPP9;DYRK1A;STXBP1;CTSC |
metal ion binding | DOM3Z;ZNF669;PSMD14;PHOSPHO2;GALNS;MOXD2;ZNF703;MTF1;ZNF625 |
protein binding | SNRPD1;SPANXC;USP36;RUSC2;SMN2;ANXA2;UGP2;PPARD;CLDN1 |
protein heterodimerization activity | ZHX1;HIST1H4H;CLCF1;AXL;NEUROD1;VEGFA;TPD52;PPARD;HIST1H2BI |
protein homodimerization activity | Anks6;ACVR1;SRM;PON3;RAB11FIP4A;ASMT;ACOT7;VAPB;MAP3K5 |
protein kinase binding | IL31RA;TRAF2;FGFR1OP;CCNY;CD3E;MAP3K1;PRKACA;RHOD;TSKS |
receptor signaling protein activity | ADRB1;SMAD1;FLRT1;NSMAF;IFITM1;KLK1B4;FLRT2;PLCG1;DOK4 |
transcription factor activity, sequence-specific DNA binding | TWIST2;ZNF205;ZNF691;SIM2;ZNF500;NME2;HOXC6;SMAD1;FOXO3 |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | HOXA10;PITX2;HMGA2;GLIS2;KLF4;ELF3;EBF3A;NUCKS1;MIXL1 |
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | SMAD2;SMAD1;SMAD9;SMAD3 |
SMAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD1.
SMAD4; GSK3B; AR
- Q&As
- Reviews
Q&As (5)
Ask a questionTechniques like Western blotting, immunohistochemistry, and qRT-PCR are commonly employed to study SMAD1 expression and activity in clinical research.
Modulating SMAD1 activity could be explored as a potential strategy for developing anti-cancer therapies, particularly in cancers where the TGF-β pathway is dysregulated.
Yes, mutations in the SMAD1 gene have been identified in certain individuals with congenital disorders and developmental abnormalities.
SMAD1 forms complexes with other SMAD proteins, transducing signals from TGF-β receptors to the nucleus, where they regulate gene expression.
Targeting SMAD1 or its downstream effectors in the TGF-β pathway may offer potential therapeutic strategies for bone-related disorders, such as osteoporosis.
Customer Reviews (3)
Write a reviewWhether I am investigating enzymatic activity, studying protein-protein interactions, or testing its role in signaling pathways, the SMAD1 protein consistently performs exceptionally well.
This versatility allows me to explore different aspects of my research with confidence and accuracy.
The SMAD1 protein's excellent functionality makes it highly suitable for various trial applications.
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