Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

SMO

  • Official Full Name

    smoothened, frizzled class receptor

  • Overview

    The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
  • Synonyms

    SMO; smoothened, frizzled class receptor; Gx; SMOH; FZD11; smoothened homolog; protein Gx; frizzled family member 11; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMO-31421TH Recombinant Human SMO Wheat Germ N/A 100 amino acids
Human SMO-31423TH Recombinant Human SMO Wheat Germ N/A 59 amino acids
Human SMO-1617HCL Recombinant Human SMO overexpression lysate HEK293T Myc/DDK
Human SMO-31422TH Recombinant Human SMO Wheat Germ N/A 135 amino acids
Human SMO-536H Recombinant Human SMO Mammalian Cell His
Human SMO-2818H Recombinant Human SMO, GST-tagged E.coli GST C-242aa
Human SMO-211H Recombinant Human SMO, StrepII-tagged Human Cell Strep II 32-233, 202 a.a.
Human SMO-1110HFL Recombinant Human SMO protein, His&Flag-tagged HEK293 His&Flag 1-787 aa
Human SMO-4097H-B Recombinant Human SMO Protein Pre-coupled Magnetic Beads HEK293
Human SMO-2707H Recombinant Human SMO Protein, His-tagged E.coli N-His Ala30-Ile234
Human SMO-6317H Recombinant Human SMO Protein (Ser32-Tyr233), N-His tagged E.coli N-His Ser32-Tyr233
Human SMO-28H Recombinant Human SMO Protein Wheat Germ N/A
Human SMO-2700H Recombinant Human SMO protein, His-tagged E. coli His 28-233 aa
Human SMO-6780HF Recombinant Full Length Human SMO Protein In Vitro Cell Free System 404 amino acids
Human SMO-314H Active Recombinant Human SMO Full Length Transmembrane protein(VLPs) HEK293 N/A Arg 28 - Phe 787
Human SMO-4097H Recombinant Human SMO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse SMO-15631M Recombinant Mouse SMO Protein Mammalian Cell His
Mouse SMO-8486M-B Recombinant Mouse SMO Protein Pre-coupled Magnetic Beads HEK293
Mouse SMO-8486M Recombinant Mouse SMO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Smo-2084M Recombinant Mouse Smo Protein, His-tagged E.coli N-His Ala33-Ile238
Rat SMO-5623R Recombinant Rat SMO Protein Mammalian Cell His
Rat SMO-5282R Recombinant Rat SMO Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SMO-5282R-B Recombinant Rat SMO Protein Pre-coupled Magnetic Beads HEK293
Gallus gallus (Chicken) RFL4256GF Recombinant Full Length Chicken Smoothened Homolog(Smo) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (16-794)
Homo sapiens (Human) RFL16147HF Recombinant Full Length Human Smoothened Homolog(Smo) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-787)
Mus musculus (Mouse) RFL28574MF Recombinant Full Length Mouse Smoothened Homolog(Smo) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-793)
Rattus norvegicus (Rat) RFL18969RF Recombinant Full Length Rat Smoothened Homolog(Smo) Protein, His-Tagged E.coli expression system His Full Length (31-793)
Zebrafish SMO-8656Z Recombinant Zebrafish SMO Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SMO Related Articles
  • SMO Related Gene Family
  • SMO Related Research Area

SMO involved in several pathways and played different roles in them. We selected most pathways SMO participated on our site, such as Hedgehog signaling pathway, Pathways in cancer, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog signaling pathwayBMP2B;IHH;WNT2B;SMO;PRKACAB;PTCH2;RAB23;Shh;BTRC
Pathways in cancerWNT6;CXCR4;FGF5;PDGFA;MSH6;FGF10;IKBKB;SLC2A1;XIAP
Proteoglycans in cancerHCLS1;TGFB2;LUM;AKT2;CDC42;FGFR1;WNT3A;ITGA2;KRAS
Basal cell carcinomaShh;WNT11;GLI1;DVL3;WNT2;AXIN1;DVL2;SMO;BMP2

SMO has several biochemical functions, for example, G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMO itself. We selected most functions SMO had, and list some proteins which have the same functions with SMO. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityTAAR6;TPRA1;MTNR1AA;OR11A1;S1PR4;ADRB2B;TAS2R126;FZD9;PTGDR2
NOT Wnt-activated receptor activitySZL;SFRP2;SFRP1A;SFRP1B;FRZB;SFRP1;SMO;SETD6;SFRP4
Wnt-protein bindingGPR177;APCDD1;SETD6;FZD8;SMO;FZD9B;SFRP1A;GM12824;PORCN
drug bindingGRIK1;ADRB2;DRD1;CYP2D6;TOP2A;NR1I2;DHODH;TLR7;FNTB
patched bindingIHH;DHH;CCNB1;PTCH1;CAV1;SMO;SETD6;BBS1;Shh
protein bindingAIM2;RPS14;ARID5A;ZNF114;ZBTB48;CPNE1;ZAP70;MED29;UIMC1

SMO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMO here. Most of them are supplied by our site. Hope this information will be useful for your research of SMO.

PTCH1; ARRB2; ARRB1; ILK; BCL6

Kebenko, M; Drenckhan, A; et al. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts. CELLULAR SIGNALLING 27:373-381(2015).
Alfaro, AC; Roberts, B; et al. Ptch2 mediates the Shh response in Ptch1(-/-) cells. DEVELOPMENT 141:3331-3339(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does the dysregulation of SMO protein contribute to cancer development? 07/30/2021

Aberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.

Are there ongoing research efforts to discover new clinical applications for SMO protein modulation? 12/29/2020

Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.

How does SMO protein modulation impact stem cell behavior and differentiation? 12/04/2020

SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.

What are the current clinical applications of SMO inhibitors in cancer treatment? 09/20/2018

SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.

In which cancer types have SMO inhibitors shown promising results in clinical trials? 05/11/2018

Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.

Customer Reviews (3)

Write a review
Reviews
11/23/2021

    The manufacturer of SMO protein plays a crucial role in supporting my research endeavors.

    11/16/2018

      The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      08/22/2018

        Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

        Ask a Question for All SMO Products

        Required fields are marked with *

        My Review for All SMO Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends