SMO
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Official Full Name
smoothened, frizzled class receptor
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Overview
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010] -
Synonyms
SMO; smoothened, frizzled class receptor; Gx; SMOH; FZD11; smoothened homolog; protein Gx; frizzled family member 11; seven transmembrane helix receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Flag
- Myc|DDK
- N/A
- N
- Strep II
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | SMO-31421TH | Recombinant Human SMO | Wheat Germ | N/A | 100 amino acids | |
Human | SMO-31423TH | Recombinant Human SMO | Wheat Germ | N/A | 59 amino acids | |
Human | SMO-1617HCL | Recombinant Human SMO overexpression lysate | HEK293T | Myc/DDK | ||
Human | SMO-31422TH | Recombinant Human SMO | Wheat Germ | N/A | 135 amino acids | |
Human | SMO-536H | Recombinant Human SMO | Mammalian Cell | His | ||
Human | SMO-2818H | Recombinant Human SMO, GST-tagged | E.coli | GST | C-242aa | |
Human | SMO-211H | Recombinant Human SMO, StrepII-tagged | Human Cell | Strep II | 32-233, 202 a.a. | |
Human | SMO-1110HFL | Recombinant Human SMO protein, His&Flag-tagged | HEK293 | His&Flag | 1-787 aa | |
Human | SMO-4097H-B | Recombinant Human SMO Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | SMO-2707H | Recombinant Human SMO Protein, His-tagged | E.coli | N-His | Ala30-Ile234 | |
Human | SMO-6317H | Recombinant Human SMO Protein (Ser32-Tyr233), N-His tagged | E.coli | N-His | Ser32-Tyr233 | |
Human | SMO-28H | Recombinant Human SMO Protein | Wheat Germ | N/A | ||
Human | SMO-2700H | Recombinant Human SMO protein, His-tagged | E. coli | His | 28-233 aa | |
Human | SMO-6780HF | Recombinant Full Length Human SMO Protein | In Vitro Cell Free System | 404 amino acids | ||
Human | SMO-314H | Active Recombinant Human SMO Full Length Transmembrane protein(VLPs) | HEK293 | N/A | Arg 28 - Phe 787 | |
Human | SMO-4097H | Recombinant Human SMO Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | SMO-15631M | Recombinant Mouse SMO Protein | Mammalian Cell | His | ||
Mouse | SMO-8486M-B | Recombinant Mouse SMO Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | SMO-8486M | Recombinant Mouse SMO Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Smo-2084M | Recombinant Mouse Smo Protein, His-tagged | E.coli | N-His | Ala33-Ile238 | |
Rat | SMO-5623R | Recombinant Rat SMO Protein | Mammalian Cell | His | ||
Rat | SMO-5282R | Recombinant Rat SMO Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | SMO-5282R-B | Recombinant Rat SMO Protein Pre-coupled Magnetic Beads | HEK293 | |||
Gallus gallus (Chicken) | RFL4256GF | Recombinant Full Length Chicken Smoothened Homolog(Smo) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (16-794) | |
Homo sapiens (Human) | RFL16147HF | Recombinant Full Length Human Smoothened Homolog(Smo) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (28-787) | |
Mus musculus (Mouse) | RFL28574MF | Recombinant Full Length Mouse Smoothened Homolog(Smo) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (33-793) | |
Rattus norvegicus (Rat) | RFL18969RF | Recombinant Full Length Rat Smoothened Homolog(Smo) Protein, His-Tagged | E.coli expression system | His | Full Length (31-793) | |
Zebrafish | SMO-8656Z | Recombinant Zebrafish SMO | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- SMO Related Articles
- SMO Related Gene Family
- SMO Related Research Area
SMO involved in several pathways and played different roles in them. We selected most pathways SMO participated on our site, such as Hedgehog signaling pathway, Pathways in cancer, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Hedgehog signaling pathway | BMP2B;IHH;WNT2B;SMO;PRKACAB;PTCH2;RAB23;Shh;BTRC |
Pathways in cancer | WNT6;CXCR4;FGF5;PDGFA;MSH6;FGF10;IKBKB;SLC2A1;XIAP |
Proteoglycans in cancer | HCLS1;TGFB2;LUM;AKT2;CDC42;FGFR1;WNT3A;ITGA2;KRAS |
Basal cell carcinoma | Shh;WNT11;GLI1;DVL3;WNT2;AXIN1;DVL2;SMO;BMP2 |
SMO has several biochemical functions, for example, G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMO itself. We selected most functions SMO had, and list some proteins which have the same functions with SMO. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein coupled receptor activity | TAAR6;TPRA1;MTNR1AA;OR11A1;S1PR4;ADRB2B;TAS2R126;FZD9;PTGDR2 |
NOT Wnt-activated receptor activity | SZL;SFRP2;SFRP1A;SFRP1B;FRZB;SFRP1;SMO;SETD6;SFRP4 |
Wnt-protein binding | GPR177;APCDD1;SETD6;FZD8;SMO;FZD9B;SFRP1A;GM12824;PORCN |
drug binding | GRIK1;ADRB2;DRD1;CYP2D6;TOP2A;NR1I2;DHODH;TLR7;FNTB |
patched binding | IHH;DHH;CCNB1;PTCH1;CAV1;SMO;SETD6;BBS1;Shh |
protein binding | AIM2;RPS14;ARID5A;ZNF114;ZBTB48;CPNE1;ZAP70;MED29;UIMC1 |
SMO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMO here. Most of them are supplied by our site. Hope this information will be useful for your research of SMO.
PTCH1; ARRB2; ARRB1; ILK; BCL6
- Q&As
- Reviews
Q&As (5)
Ask a questionAberrant activation of the SMO protein is associated with several types of cancer, including basal cell carcinoma and medulloblastoma. Mutations or overexpression of SMO can lead to uncontrolled cell growth and tumorigenesis.
Yes, researchers are actively investigating the role of SMO protein in various diseases beyond cancer, including neurological disorders and regenerative medicine.
SMO protein modulation can influence stem cell fate decisions, playing a role in processes such as self-renewal and differentiation.
SMO inhibitors are being explored as therapeutic agents in cancer treatment, particularly for tumors driven by abnormal Hedgehog signaling. These inhibitors aim to block the activity of SMO and, consequently, disrupt the downstream signaling cascade.
Clinical trials have shown promise for SMO inhibitors in treating basal cell carcinoma, medulloblastoma, and other cancers with dysregulated Hedgehog signaling.
Customer Reviews (3)
Write a reviewThe manufacturer of SMO protein plays a crucial role in supporting my research endeavors.
The use of SMO protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.
Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.
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