SP1

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SP1

Official Full Name Sp1 transcription factor
Background The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Synonyms SP1; Sp1 transcription factor; transcription factor Sp1; specificity protein 1;
    • Type:
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HeLa
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • HA
    • Flag
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SP1-1157H Recombinant Human Sp1 Transcription Factor HeLa N/A
    Human SP1-1158H Recombinant Human Sp1 Transcription Factor, His-tagged Sf9 Insect Cell His
    Human SP1-1159H Recombinant Human Sp1 Transcription Factor, GST-tagged E.coli GST
    Human SP1-16H Recombinant Human SP1 protein, His-tagged E.coli His
    Human SP1-1956H Recombinant Human SP1 protein, His & GST-tagged E.coli His/GST
    Human SP1-2093H Recombinant Human SP1, HA & Flag-tagged Insect Cell HA/Flag
    Human SP1-30608TH Recombinant Human SP1 E.coli N/A
    Human SP1-30987TH Recombinant Human SP1, His-tagged E.coli His
    Human SP1-590H Recombinant Human Sp1 Transcription Factor Sf9 Insect Cell N/A
    Human SP1-8511H Recombinant Human SP1, GST-tagged E.coli GST
    Rat SP1-5677R Recombinant Rat SP1 Protein Mammalian Cell His
    Rhesus Macaque SP1-4417R Recombinant Rhesus monkey SP1 Protein, His-tagged Mammalian Cell His
    Chicken SP1-6172C Recombinant Chicken SP1 Mammalian Cell His
    Zebrafish SP1-11938Z Recombinant Zebrafish SP1 Mammalian Cell His

    SP1 involved in several pathways and played different roles in them. We selected most pathways SP1 participated on our site, such as TGF-beta signaling pathway, Estrogen signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TGF-beta signaling pathway TGFB2; TGFB1A; LFT2; CUL1; INHBE; BMP7A; PPP2CB; NDR1; BMPR1AA; SP1
    Estrogen signaling pathway SHC2; SHC4; CREB3L3; PIK3R2; CREB5; PIK3R1; MAP2K2; GNAI1; SHC3; PLCB1
    Huntingtons disease SLC25A31; SLC25A5; DCTN1; POLR2F; CREB3L1; ATP5D; COX6B1; NDUFB2; CREB3L2; COX4I1
    Transcriptional misregulation in cancer FUT8; DEFA3; HIST2H3C2; PER2; MMP3; RUNX1T1; PDGFA; BMI1; TMPRSS2; ETV4
    Choline metabolism in cancer RAC3; PIP5K1A; GRB2; NRAS; PRKCG; RALGDS; PDGFRB; RPS6KB1; PIK3CA; MAP2K2

    SP1 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP1 itself. We selected most functions SP1 had, and list some proteins which have the same functions with SP1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding MSXB; TBX5B; ZFP93; JRK; HOXD13A; PARP2; TCEA3; SIX6B; FOXO3B; SALL1
    HMG box domain binding GATA3; POU3F3; DLX5; ALX4; CEBPA; PRRX1; UTF1; HOXC4; HHEX; HOXA3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding TCF3A; NRF1; TBX3; FOXI1; SPI1; MYF5; ZNF695; MEIS1; PGR; NR6A1
    RNA polymerase II core promoter sequence-specific DNA binding TAL1; PAX8; RUNX2; NR4A2; MTF1; RREB1; WBP2; NSD1; YAP1; H2AFZ
    RNA polymerase II regulatory region sequence-specific DNA binding NME2; ZSCAN2; HMX3; HOXD9; ZNF583; STAT4; GATA1A; NEUROD2; ZMYND11; GATA2
    RNA polymerase II repressing transcription factor binding GSC; BBS2; SIN3A; TTC8; SP1; MTA1; BBS1; PROL1; HDAC2; HDAC1
    RNA polymerase II transcription factor activity, sequence-specific DNA binding PLAGX; ETS1; TFDP1B; TFAP2A; TFAP2E; MEF2D; SP4; FOXN1; ELF3; PAX6A
    bHLH transcription factor binding TCF4; TCF3B; TCF3; USF2; HAND1; IKZF4; TCF12; SP1; ASCL1; ISL1
    core promoter sequence-specific DNA binding NR1D2; SP1; NR4A3; SOX9; CREM; SOX4; SOHLH1; MTA1; NFYA; ZFHX3
    double-stranded DNA binding RAD51AP1; HES2; PNKP; MTERFD1; MRE11A; HMGB2; KLF6; NKX2-8; FBXO18; SETMAR
    enhancer binding AHR; TIPARP; TCF3; SMAD3; SP1; FOXH1; ARNT; ELL3; LEF1; TCF12
    histone acetyltransferase binding SIRT2; PAX6; EPAS1; EID1; ETS1; TAF7L; ZBTB7A; MEF2A; MYOCD; EGR1
    histone deacetylase binding SFPQ; GLI3; RELA; MECP2; DNMT3B; HES1; TOP2A; HDAC1; KPNA2; USF1
    metal ion binding TRIM41; PDE1B; ZFP354C; TRP53; ZC4H2; ZNF584; NCALDB; ZNF263; CH25HL2; EGR4
    protein C-terminus binding HAND2; SCLT1; CTBP1; SREBF2; XRCC4; DYNLL1; MRE11A; MKI67; AXIN1; YEATS4
    protein binding SHOX; CREB3L3; LUC7L2; TRAF6; LANCL2; CEP120; STX8; FNBP1; PAPOLA; CD300LG
    protein homodimerization activity CRYAB; LRRK2; SLC26A5; SLC24A6; HAND1; TYRP1; SLC9A7; GDF7; EXT1; TBX18
    sequence-specific DNA binding PKNOX1.1; PBX1B; ESRRB; DMRT3; HOXC13A; RXRGA; ATF5; FOXJ1B; NFIL3-2; DLX2A
    transcription factor activity, sequence-specific DNA binding ZNF649; ZNF317; PPARD; STAT2; ZNF16; SNAPC4; KDM3A; SIN3A; NR1D1; FOXI3B
    transcription factor binding PPRC1; NFATC3; APBB1; BCL10; IFT172; RARA; PELP1; HDAC8; FOS; ARRB1
    transcription regulatory region DNA binding BCOR; MEF2C; XRCC5; BCL11AB; SALL4; ZFP161; CTCFL; CCNT1; RBBP5; SREBF1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ONECUT2; ZFP292; NRF1; MZF1; SPI1; PHOX2B; MYB; ZFAT; SMAD1; FOXI1

    SP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP1.

    POU2F1; STAT3; HCFC1; SREBF2; tf65_human_gc-box3_dna-probe

    Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).
    Shen, L; Kapsogeorgou, EK; et al. Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome. CLINICAL IMMUNOLOGY 155:42-46(2014).

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