sp1
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  • Official Full Name
  • Sp1 transcription factor
  • Background
  • The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • Synonyms
  • SP1; Sp1 transcription factor; transcription factor Sp1; specificity protein 1;
Cat.#:SP1-1159HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sp1 Transcription Factor, GST-tagged
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Cat.#:SP1-16HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP1 protein, His-tagged
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Cat.#:SP1-1956HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP1 protein, His & GST-tagged
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Cat.#:SP1-2093HTag:HA/Flag
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SP1, HA & Flag-tagged
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Cat.#:SP1-30608THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP1
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Cat.#:SP1-30987THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP1, His-tagged
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Cat.#:SP1-590HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sp1 Transcription Factor
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Cat.#:SP1-8511HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SP1, GST-tagged
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Cat.#:SP1-5677RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SP1 Protein
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Cat.#:SP1-4417RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SP1 Protein, His-tagged
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Cat.#:SP1-6172CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SP1
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Cat.#:SP1-11938ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SP1
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Cat.#:SP1-1157HTag:N/A
Source (Host):HeLa cellsSpecies:Human
Product nameRecombinant Human Sp1 Transcription Factor
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Cat.#:SP1-1158HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sp1 Transcription Factor, His-tagged
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Involved Pathway

SP1 involved in several pathways and played different roles in them. We selected most pathways SP1 participated on our site, such as TGF-beta signaling pathway, Estrogen signaling pathway, Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
ID2B; SMAD3A; TGFB2; ZFYVE16; RHOAC; SMAD1; RHOAB; INHBE; E2F5; CHRD
Estrogen signaling pathway
MAPK3; CALM1; AKT2; CALML5; PRKACA; NRAS; PLCB3; Adcy4; PLCB4; HSP90B1
Huntingtons disease
PLCB3; GRM5; COX5B; DNAH5; COX7A2L; NDUFB7; UQCRC2; NDUFV3; DNAH14; CASP8
Transcriptional misregulation in cancer
ZBTB17; H3F3C; TRP53; BCL2A1A; RXRB; DDX5; SFPI1; ERG; HIST2H3C1; FUS
Choline metabolism in cancer
PRKCA; MAPK10; MTOR; KRAS; Pdgfa&Pdgfb; PIK3CA; DGKZ; FOS; PLA2G4F; SLC44A1

Protein Function

SP1 has several biochemical functions, for example, DNA binding, HMG box domain binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SP1 itself. We selected most functions SP1 had, and list some proteins which have the same functions with SP1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZHX3; HIST1H110; ARHGAP35; VEPH1; ZNF653; SIM1A; HOXD11A; NR6A1; ZNF326; SMYD1
Function HMG box domain binding
Related Protein EGR2; HOXC4; HHEX; CEBPA; HOXA3; SP1; JUN; UTF1; POU3F3; GATA3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HNRNPC; ISL1; MYC; CEBPE; ZNF664; JUNBB; ZBTB7A; HNRNPK; DDN; ZGPAT
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein ZNF277; TRP53; HNF4A; EGR1; SOX8; TFAP2A; GATA6; FOS; NFIL3; RUVBL2
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein CREB3; NHLH2; LYL1; ATF6; ZNF561; EGR1; MEF2A; PRDM15; TAL1; PAX9
Function RNA polymerase II repressing transcription factor binding
Related Protein MIXL1; CHD4; TCERG1; TBP; MKKS; TTC8; PROL1; DMAP1; STAT3; RBPJ
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein SOX5; OVOL2; NPAS1; MITFB; FOXQ1B; FOXE1; FOXG1B; FOXD5; TAL2; HOXA13A
Function bHLH transcription factor binding
Related Protein SP1; HAND1; SOX9; FOXH1; RUNX2; TCF21; BHLHE40; EP300; ISL1; TWIST1
Function core promoter sequence-specific DNA binding
Related Protein C1orf51; NR1D2; SOHLH2; MYOCD; ZNF750; SOX9; SOHLH1; SOX4; MLL1; CHD2
Function double-stranded DNA binding
Related Protein APTX; FEN1; AFF3; EGFR; TEF; HES2; NEIL3; RAD51L1; DMC1; MTERFD2
Function enhancer binding
Related Protein TIPARP; TCF3; ELL3; RAI1; SMAD3; FOXH1; MESP1; TCF12; ARNT; AHR
Function histone acetyltransferase binding
Related Protein ZBTB7A; EPAS1; TRIP4; KAT2B; EGR1; TRP53; HIF1A; FOXP3; NR4A3; EID1
Function histone deacetylase binding
Related Protein SP1; HEY2; PARK2; TAL1; HDAC3; NRIP1; TFAP4; HIF1A; PRDM1; SIRT2
Function metal ion binding
Related Protein Adamts19; TRP63; ZBTB9; ZFP598; NGLY1; USP19; ZFP518A; SMG6; ZNFL2A; CSRP1B
Function protein C-terminus binding
Related Protein VGLL1; TCF4; DYNLL1; DLG3; SNF8; MAP3K7; JAK2; ID1; BCAM; XRCC5
Function protein binding
Related Protein TIMM50; USP44; SFTPC; SNRPA1; NR1H3; CASP10; NFASC; APBB1IP; DDX21; DYRK1A
Function protein homodimerization activity
Related Protein UBE4A; NR4A3; FLT3LG; DMBX1; CDA; CPOX; BLOC1S6; CADM1B; IKZF2; HRSP12
Function sequence-specific DNA binding
Related Protein FOXG1C; HLF; POU3F1; HOXB3A; RBPJ; NR1D2B; ZFP110; GLI2; TLX2; HOXA10B
Function transcription factor activity, sequence-specific DNA binding
Related Protein ASCL2; POU3F3B; FOXI3A; ENO1; STAT3; DMRT2B; HIVEP2A; ARNTL1B; FOSL1A; VDRA
Function transcription factor binding
Related Protein KAT2B; YWHAZ; HDAC11; FOSB; REST; PIAS2; HEYL; SORBS3; EPN1; NFATC3
Function transcription regulatory region DNA binding
Related Protein SFPQ; ERBB4; TFAP2A; BRD7; GABPB1; PPARG; HOXA13; WNT5A; BCL11AB; SNCA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein TCF12; NFKB2; NR4A2; RELA; MEIS3; FUBP3; CAMTA1; PITX3; KLF4; SIX1

Interacting Protein

SP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SP1.
POU2F1; STAT3; HCFC1; SREBF2; tf65_human_gc-box3_dna-probe

SP1 Related Articles

Wang, YD; Rajanbabu, V; et al. Transcriptome analysis of medaka following epinecidin-1 and TH1-5 treatment of NNV infection. FISH & SHELLFISH IMMUNOLOGY 42:121-131(2015).
Shen, L; Kapsogeorgou, EK; et al. Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome. CLINICAL IMMUNOLOGY 155:42-46(2014).