TARDBP
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Official Full Name
TAR DNA binding protein
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Overview
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008] -
Synonyms
TARDBP; TAR DNA binding protein; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Sf9 insect cells
- Wheat Germ
- Yeast
- DDK
- Flag
- GST
- His
- SUMO
- Myc
- Myc|DDK
- N/A
- N
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- TARDBP Related Articles
- TARDBP Related Research Area
TARDBP involved in several pathways and played different roles in them. We selected most pathways TARDBP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TARDBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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TARDBP has several biochemical functions, for example, RNA binding, double-stranded DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TARDBP itself. We selected most functions TARDBP had, and list some proteins which have the same functions with TARDBP. You can find most of the proteins on our site.
Function | Related Protein |
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RNA binding | RBM12B1;RBM4B;A1CF;RAD51AP1;NCL;SNRPA;BRCA1;RBMS3;AHCYL1 |
double-stranded DNA binding | FBXO18;RAD51D;RAD51B;HLF;PNKP;ERCC5;SP1;TRP53;NTHL1 |
identical protein binding | ATF3;HACL1;DYNLT1;ADORA2A;PNMA5;KCTD17;HCN2;ECI1;RAD52 |
mRNA 3-UTR binding | CPEB3;RNPS1;HNRNPC;CSDA;CPEB1A;CRYZ;CARHSP1;RBMS3;IGF2BP3 |
nucleotide binding | HNRNPA0;MAPK12B;PPRC1;JAK2A;ARL3L2;SRSF9;ABCG5;GNA11B;TLK1B |
poly(A) RNA binding | AGO3;FDPS;BZW1;C14orf21;ERAL1;SUMO2;H1FX;NOVA2;POLRMT |
protein binding | GATA5;TLE4;RNF34;BFSP1;PPP2R5D;TMEM190;TTC6;TIRAP;C1GALT1C1 |
transcription factor activity, sequence-specific DNA binding | RFX2;MYCS;HMGB2;NKX2-8;ASCL1;ZNF287;LHX8A;ZNF668;TEF |
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | HOXB5;PROP1;SPI1;SUB1;NFATC1;NFE2L1;CDX1;MIXL1;HMGA1 |
TARDBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TARDBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TARDBP.
IRAK2; HLA-B
- Q&As
- Reviews
Q&As (6)
Ask a questionTARDBP may influence the growth and survival of neurons by regulating processes such as protein synthesis and intracellular transport. It may also be involved in regulating neuronal signaling and synaptic function.
The structure of TARDBP determines its ability to bind to RNA and its interaction with ribosomes and other molecules. The study of its structure can help us understand its function and mechanism of action.
There are currently no therapies that directly regulate TARDBP expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.
In the nervous system, TARDBP may be involved in the development and function of neurons. Studies have shown that its expression levels are associated with neurological disorders such as ALS and FTD.
The expression level of TARDBP can be regulated in a variety of ways, including transcription, post-transcriptional modification, and degradation. These processes may involve various molecules such as transcription factors, regulatory Rnas, and signal transduction pathways.
Studies have shown that TARDBP expression levels are associated with certain neurological diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases may be related to the abnormal function of TARDBP.
Customer Reviews (3)
Write a reviewThere is no interaction with other reagents, and there is no influence.
The catalytic activity is very good, and the catalytic performance can be maintained in any environment.
TARDBP has good solubility and can be easily dissolved in a variety of buffers.
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