tardbp
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  • Official Full Name
  • TAR DNA binding protein
  • Background
  • HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TARDBP; TAR DNA binding protein; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43;
Cat.#:TARDBP-2192HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human TARDBP Protein (1-396 aa), His-tagged
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Cat.#:TARDBP-22HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP Protein
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Cat.#:TARDBP-2993HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TAR DNA Binding Protein, T7-tagged
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Cat.#:TARDBP-30150THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP
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Cat.#:TARDBP-3114HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP, His-tagged
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Cat.#:TARDBP-35HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TARDBP, MYC/DDK-tagged
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Cat.#:TARDBP-36HTag:DDK
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TARDBP, DDK-tagged
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Cat.#:TARDBP-39HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP protein, GST-tagged
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Cat.#:TARDBP-40HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP protein, GST-tagged
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Cat.#:TARDBP-4735HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TARDBP, GST-tagged
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Cat.#:TARDBP-7588HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP, His-tagged
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Cat.#:TARDBP-85HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TARDBP, His-tagged
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Cat.#:Tardbp-2006MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tardbp protein, His-tagged
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Cat.#:TARDBP-2569CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TARDBP
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Cat.#:TARDBP-11522ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TARDBP
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Cat.#:TARDBP-1251HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TARDBP 293 Cell Lysate
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Protein Function

TARDBP has several biochemical functions, for example, RNA binding, double-stranded DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TARDBP itself. We selected most functions TARDBP had, and list some proteins which have the same functions with TARDBP. You can find most of the proteins on our site.
Function
Related Protein
Function RNA binding
Related Protein SNRPD1; CSTF1; CELF6; PATL1; PAPOLB; SPI1; XPO1; TTC6; FAU; SKIV2L
Function double-stranded DNA binding
Related Protein HMGB2; HLF; RAD51B; AFF3; USF1; EGFR; TEF; RAD51L3; PRKDC; PIN4
Function identical protein binding
Related Protein PHYKPL; GOT2A; MPST; SCUBE1; DYNLT1F; RGMB; CLDN9; SIAH1A; SHANK1; TRA@
Function mRNA 3-UTR binding
Related Protein CIRBP; RIMS2; IGF2BP3; ZNF385A; ELAVL1; FXR1; PARN; RNF20; TARDBP; ELAVL2
Function nucleotide binding
Related Protein RAB34A; GNAV1; RHOAB; CDC42L2; CHD1L; GNAO1B; RALAB; MAT2AB; UBE2L3A; VDAC2
Function poly(A) RNA binding
Related Protein EIF3A; EIF5A; FKBP3; SCG3; THRAP3; TFRC; HIST1H47; PCSK9; ZC3H11A; RPS19
Function protein binding
Related Protein CCL20; MT1G; KEAP1; CACNA1SB; MPZL1; RGS2; MLST8; GAS6; RAB38; MLPH
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZKSCAN1; ZFP110; ZFP28; MNX1; ZNF263; ZBTB17; PHF5A; NR4A2A; MGAA; SMAD9
Function transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein SIX6; NFE2L1; FUBP1; PBX3; NFKB1; PROP1; MEOX2; HCFC1; NFATC1; NFE2L2

Interacting Protein

TARDBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TARDBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TARDBP.
IRAK2; HLA-B

TARDBP Related Articles

Droppelmann, CA; Wang, J; et al. Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis. AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION 14:444-451(2013).
El-Assaad, I; Di Bari, JA; et al. Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker. VETERINARY RESEARCH COMMUNICATIONS 36:221-226(2012).