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TARDBP

  • Official Full Name

    TAR DNA binding protein

  • Overview

    HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
  • Synonyms

    TARDBP; TAR DNA binding protein; ALS10; TDP-43; TAR DNA-binding protein 43; TAR DNA-binding protein-43;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • Sf9 insect cells
  • Wheat Germ
  • Yeast
  • DDK
  • Flag
  • GST
  • His
  • SUMO
  • Myc
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TARDBP-85H Recombinant Human TARDBP, His-tagged E.coli His
Human TARDBP-2993H Recombinant Human TAR DNA Binding Protein, T7-tagged E.coli T7
Human TARDBP-4735H Recombinant Human TARDBP, GST-tagged Wheat Germ GST
Human TARDBP-36H Recombinant Human TARDBP, DDK-tagged Sf9 Insect Cell DDK
Human TARDBP-3114H Recombinant Human TARDBP, His-tagged E.coli His C-term-154aa
Human TARDBP-30150TH Recombinant Human TARDBP E.coli N/A
Human TARDBP-40H Recombinant Human TARDBP protein, GST-tagged E.coli GST 261-414aa
Human TARDBP-7588H Recombinant Human TARDBP, His-tagged E.coli His 1-260aa
Human TARDBP-35H Recombinant Human TARDBP, MYC/DDK-tagged HEK293 Myc/DDK
Human TARDBP-39H Recombinant Human TARDBP protein, GST-tagged E.coli GST 1 - 260 aa
Human TARDBP-1251HCL Recombinant Human TARDBP 293 Cell Lysate HEK293 N/A
Human TARDBP-41H Recombinant Human TARDBP Protein (Full length), N-GST-tagged Sf9 insect cells N-GST Full Length
Human TARDBP-1429H Recombinant Human TARDBP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human TARDBP-22H Recombinant Human TARDBP Protein E.coli N/A
Human TARDBP-3552H Recombinant Human TARDBP protein, His-SUMO-tagged E.coli His-SUMO 1-396aa
Human TARDBP-0740H Active Recombinant Human TARDBP protein, His-tagged E.coli His Met1-Met414
Human TARDBP-116H Recombinant Human TARDBP Protein, GST-tagged E.coli GST
Human TARDBP-2192H Recombinant Human TARDBP Protein (1-396 aa), His-tagged Yeast His 1-396 aa
Human TARDBP-5776H Recombinant Human TARDBP Protein (Ser104-Pro262), N-His tagged E.coli N-His Ser104-Pro262
Human TARDBP-3345HFL Recombinant Full Length Human TARDBP, Flag-tagged Mamanlian cells Flag
Mouse Tardbp-2006M Recombinant Mouse Tardbp protein, His-tagged E.coli His Ser104~Pro262 (Accession # Q921F2)
Mouse Tardbp-6294M Recombinant Mouse Tardbp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish TARDBP-11522Z Recombinant Zebrafish TARDBP Mammalian Cell His
Chicken TARDBP-2569C Recombinant Chicken TARDBP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TARDBP Related Articles
  • TARDBP Related Research Area

TARDBP involved in several pathways and played different roles in them. We selected most pathways TARDBP participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TARDBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

TARDBP has several biochemical functions, for example, RNA binding, double-stranded DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TARDBP itself. We selected most functions TARDBP had, and list some proteins which have the same functions with TARDBP. You can find most of the proteins on our site.

Function Related Protein
RNA bindingIFIT5;THOC6;ZNF638;SNRPE;U2SURP;RALY;SKIV2L;THOC1;SPI1
double-stranded DNA bindingTP63;APTX;ZNF638;MTERFD1;DMC1;FBXO18;TDP1;RAD51C;CGGBP1
identical protein bindingRASSF1;AMOTL2;CSNK2B;SMAD4;DYNLT1A;TK1;MSTN;SLIT2;TNN
mRNA 3-UTR bindingCSDA;HNRNPC;CPEB4;CPEB1B;KHSRP;RNF20;RBMS3;CRYZ;PARN
nucleotide bindingSCAF8;HPRT1;CDK12;TUBA2;PRKCHB;AKAP7;MAP2K4A;CAMK1DA;RBM10
poly(A) RNA bindingSRP54A;DEK;NQO1;PRDX1;PATL1;ZC3H15;FAM120B;CSRP1;SYF2
protein bindingTRIM50;PLEKHM1;KLC2;ARHGEF38;CFL1;FZD2;TRPV6;ARHGAP9;TPRGL
transcription factor activity, sequence-specific DNA bindingOTX1A;CLOCKA;BRD8;NFIA;MYCN;CEBPD;DMRTC1B;CNOT8;SMAD3B
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingNFKB1;MIXL1;PROP1;RELA;NFATC1;POU4F1;HMGA1;SFPI1;ARID3B

TARDBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TARDBP here. Most of them are supplied by our site. Hope this information will be useful for your research of TARDBP.

IRAK2; HLA-B

Droppelmann, CA; Wang, J; et al. Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis. AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION 14:444-451(2013).
El-Assaad, I; Di Bari, JA; et al. Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker. VETERINARY RESEARCH COMMUNICATIONS 36:221-226(2012).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
How does TARDBP affect the growth and survival of neurons? 10/20/2023

TARDBP may influence the growth and survival of neurons by regulating processes such as protein synthesis and intracellular transport. It may also be involved in regulating neuronal signaling and synaptic function.

Does the structure of TARDBP relate to its function? 07/19/2023

The structure of TARDBP determines its ability to bind to RNA and its interaction with ribosomes and other molecules. The study of its structure can help us understand its function and mechanism of action.

Is it possible to treat disease by modulating TARDBP expression? 10/24/2022

There are currently no therapies that directly regulate TARDBP expression. However, its function and interacting molecules can be studied to understand its mechanism of action and discover potential treatments.

What is the function of TARDBP in the nervous system? 10/24/2021

In the nervous system, TARDBP may be involved in the development and function of neurons. Studies have shown that its expression levels are associated with neurological disorders such as ALS and FTD.

Can TARDBP expression be regulated? 06/29/2021

The expression level of TARDBP can be regulated in a variety of ways, including transcription, post-transcriptional modification, and degradation. These processes may involve various molecules such as transcription factors, regulatory Rnas, and signal transduction pathways.

How is the expression level of TARDBP associated with disease? 11/22/2020

Studies have shown that TARDBP expression levels are associated with certain neurological diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These diseases may be related to the abnormal function of TARDBP.

Customer Reviews (3)

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Reviews
10/19/2021

    There is no interaction with other reagents, and there is no influence.

    07/10/2021

      The catalytic activity is very good, and the catalytic performance can be maintained in any environment.

      09/22/2020

        TARDBP has good solubility and can be easily dissolved in a variety of buffers.

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