TRIM21
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Official Full Name
tripartite motif containing 21
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Overview
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. -
Synonyms
TRIM21; tripartite motif containing 21; SSA; RO52; SSA1; RNF81; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; OTTHUMP00000230775; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro);
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cow
- Human
- Mouse
- Rat
- Rhesus Macaque
- Bovine Thymus
- Confidential
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- TRIM21 Related Articles
- TRIM21 Related Research Area
TRIM21 involved in several pathways and played different roles in them. We selected most pathways TRIM21 participated on our site, such as Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Systemic lupus erythematosus | HIST3H2BB-PS;CD28;HIST1H2BB;C6;GM14479;H2AFX;C5;HIST1H4F;HLA-DQA2 |
TRIM21 has several biochemical functions, for example, DNA binding, RNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM21 itself. We selected most functions TRIM21 had, and list some proteins which have the same functions with TRIM21. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | NPAS1;ZNF180;HER13;SMC1B;POGK;HMGA1B;ZFP687;NFAT5A;IRF2 |
| RNA binding | KHDC1A;AGFG1A;D19BWG1357E;SAMHD1;RBMY1B;RPL3;RBM39A;PRAC;PCBP1 |
| identical protein binding | KHDRBS1;LEPR;MID1;APOE;ZNF3;GLE1;FBP1;NONO;IGF1R |
| ligase activity | RC3H2;LRSAM1;TRIM63;ACSL1;RNF138;TRIM38;RNF144AA;PRP19;HERC6 |
| protein binding | KIAA1530;TYROBP;TOM1L1;POSTN;RPL23;JUN;INO80E;KRT7;RGP1 |
| ubiquitin-protein transferase activity | UBE3C;RNF130;MYCBP2;RNF144AB;PDZRN3;TRIM23;FBXO7;RNF41;FBXL21 |
| zinc ion binding | DPEP1;SHANK3;ZRANB2;USP20;MARCH7;NR3C1;ADAMTS5;FHL1A;PDZRN3B |
TRIM21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM21.
TRIM39; 3500; GRAP; UBE2I; TXN2
- Q&As
- Reviews
Q&As (5)
Ask a questionTRIM21 has demonstrated efficacy against a broad range of viruses, including but not limited to influenza, herpes simplex virus, and adenovirus.
TRIM21 acts as an intracellular antibody receptor, binding to antibodies that have attached to viruses inside the cell. This binding triggers a process that leads to the destruction of the virus.
TRIM21 has promising applications in various clinical settings, particularly in the development of therapies for viral infections and autoimmune diseases.
TRIM21's role in regulating immune responses makes it a potential target for therapies aimed at modulating the immune system in autoimmune diseases.
Yes, TRIM21's ability to target and degrade antibody-bound viruses makes it a potential candidate for antiviral therapies.
Customer Reviews (3)
Write a reviewThey can provide fast and efficient delivery services, minimizing any potential delays and allowing researchers to proceed with their studies in a timely manner.
The manufacturer can provide researchers with a high-quality, purified form of TRIM21 protein, ensuring its integrity and functionality for experimental use.
A manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.
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