trim21
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  • Official Full Name
  • tripartite motif containing 21
  • Background
  • This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
  • Synonyms
  • TRIM21; tripartite motif containing 21; SSA; RO52; SSA1; RNF81; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; OTTHUMP00000230775; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
Cat.#:TRIM21-671HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human TRIM21 Protein (Met1-Tyr475), His-tagged
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Cat.#:TRIM21-105HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRIM21, MYC/DDK-tagged
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Cat.#:TRIM21-106HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRIM21, GST-tagged
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Cat.#:TRIM21-115HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TRIM21, His-tagged
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Cat.#:TRIM21-30033THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TRIM21
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Cat.#:TRIM21-543HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRIM21 Protein, His-tagged
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Cat.#:TRIM21-564HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human TRIM21 protein, His-tagged
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Cat.#:Trim21-542MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse TRIM21 Protein, His-tagged
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Cat.#:Trim21-1674RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Trim21 protein, His & T7-tagged
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Cat.#:TRIM21-4954RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRIM21 Protein, His-tagged
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Cat.#:TRIM21-196HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human tripartite motif-containing 21
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Cat.#:TRIM21-212BTag:
Source (Host):Bovine thymus tissueSpecies:Cow
Product nameNative Cow TRIM21
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Cat.#:TRIM21-791HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRIM21 293 Cell Lysate
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Involved Pathway

TRIM21 involved in several pathways and played different roles in them. We selected most pathways TRIM21 participated on our site, such as Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Systemic lupus erythematosus
HIST1H4D; SSB; H2AFX; HIST2H2AC; HLA-DRB4; HIST1H2BQ; HIST1H2AF; HIST1H4H; CD86; HLA-DOB

Protein Function

TRIM21 has several biochemical functions, for example, DNA binding, RNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM21 itself. We selected most functions TRIM21 had, and list some proteins which have the same functions with TRIM21. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RARAB; MEF2C; RNF6; HIST2H2L; ZFP521; ZNF574; C1D; SSH2; GLYR1; SIX6A
Function RNA binding
Related Protein NSUN5B; C14orf166; RNASEL3; ZNF74; RBM5; THOC1; RPL18; CNOT7; ETF1; AGFG1A
Function identical protein binding
Related Protein GRASP; UBQLN1; PKD2L1; PKD2; CD74; RALYL; TFRC; SH3GLB1; TMEM173; SERPINB1A
Function ligase activity
Related Protein FPGS; TRIM8; CCNB1IP1; MIB1; DZIP3; PIAS3; PCXA; TRIM6; GLULB; MARCH6
Function protein binding
Related Protein MED1; FAM189B; AK3; CLIC3; SF3A1; ATMIN; GFER; CIB3; ZNF792; ERCC2
Function ubiquitin-protein transferase activity
Related Protein UBE2K; LRSAM1; RNF115; RNF182; BRCA1; TRIM68; TRIM69; BIRC3; TRIM17; TRIM32
Function zinc ion binding
Related Protein ZNF346; MT2; DTX3L; LHX2; PPARD; ZNF598; Car12; NEURL3; ZDHHC5; ZFP326

Interacting Protein

TRIM21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM21.
TRIM39; 3500; GRAP; UBE2I; TXN2

TRIM21 Related Articles

Massie, C; Hudson, M; et al. Absence of an association between anti-Ro antibodies and prolonged QTc interval in systemic sclerosis: A multicenter study of 689 patients. SEMINARS IN ARTHRITIS AND RHEUMATISM 44:338-344(2014).
Rakebrandt, N; Lentes, S; et al. Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica. PATHOGENS AND DISEASE 72:131-137(2014).