UBE3A Protein, ubiquitin protein ligase E3A

UBE3A

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UBE3A

Official Full Name ubiquitin protein ligase E3A
Background UBE3A, also commonly referred to as E6AP (E6 Associated Protein), is an E3 ubiquitin protein ligase and founding member of the HECT (Homologous to the E6 Carboxyl Terminus) family of E3 ligases (1). UBE3A has been shown to be hijacked by the oncogenic E6
Synonyms UBE3A; ubiquitin protein ligase E3A; EPVE6AP, HPVE6A, human papilloma virus E6 associated protein; ubiquitin-protein ligase E3A; ANCR; Angelman syndrome; AS; E6 AP; FLJ26981; CTCL tumor antigen se37-2; E6AP ubiquitin-protein ligase; renal carcinoma antig; E6-AP; HPVE6A; EPVE6AP
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE3A-1657H Recombinant Human UBE3A Protein, His-tagged Insect cells His
    Mouse UBE3A-1986M Recombinant Mouse UBE3A Protein (542-870 aa), His-tagged E.coli His
    Mouse UBE3A-2022M Recombinant Mouse UBE3A Protein (542-870 aa), His-tagged Yeast His
    Human UBE3A-315H Recombinant Human UBE3A Protein E.coli N/A
    Human UBE3A-1463H Recombinant Human UBE3A protein, His-tagged E.coli His
    Human UBE3A-3550H Recombinant Human UBE3A, GST-tagged E.coli GST
    Human UBE3A-557HCL Recombinant Human UBE3A 293 Cell Lysate HEK293 N/A
    Rhesus Macaque UBE3A-5071R Recombinant Rhesus monkey UBE3A Protein, His-tagged Mammalian Cell His
    Zebrafish UBE3A-1710Z Recombinant Zebrafish UBE3A Mammalian Cell His

    UBE3A involved in several pathways and played different roles in them. We selected most pathways UBE3A participated on our site, such as Ubiquitin mediated proteolysis, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis UBE2D2; UBE2U; UBA2; RNF7; SIAH1A; SOCS3B; RHOBTB1; UBA1; UBE2J1; TCEB1B
    Viral carcinogenesis STAT5B; LYN; HDAC10; CREB3L3; PRKACA; CASP8; GTF2H2C; PRKACB; CREB3L2; BAX

    UBE3A has several biochemical functions, for example, ligase activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE3A itself. We selected most functions UBE3A had, and list some proteins which have the same functions with UBE3A. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity UBR3; RNF126; MKRN1; PIAS2; DTX4; UBOX5; ATG3; HERC5; RNF216; EGR2
    metal ion binding SRSF7A; TRIM71; TRIM36; ZNF74; ZBTB8A; SETDB1A; PLAGL2; FGD5; NUFIP1; KLF8
    protein binding CCNC; FEM1C; MST1R; PITPNC1; DAXX; RUSC1; SRI; DTNA; ACAA2; NMRK1
    ubiquitin protein ligase activity UHRF1; ZSWIM2; UBE2Z; UBE2W; UBE2V2; ARIH1; CCNC; RBBP6; HECW2; BTRC
    ubiquitin-protein transferase activity ZYG11B; UBE2G2; CDC34; UBE2O; PARK2; UBE2L6; TRIM71; RAG1; FBXO22; XIAP

    UBE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE3A.

    E6; E6; E6; E6; E6; TP53; JADE1

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