Recombinant Human UBE3A Protein

• Cat.No.: UBE3A-315H
• Product Overview: Recombinant Human UBE3A Protein is produced by Bacteria expression system.

Specification

• Description: UbE3A (also called E6AP) is a 100 kDa HECT (homologous to E6AP carboxyl terminus) domain ubiquitin ligase containing two E2 binding sites for UbcH7 and UbcH8. UbE3A was found to bind to the human papillomavirus (HPV) oncoprotein E6 and mediate ubiquitination of p53. A frameshift mutation in the UbE3A gene leads to loss of function and causes Angelman Syndrome.
• Source: Bacteria
• Species: Human
• Form: 20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
• Molecular Mass: 100.7 kDa
• Purity: > 90 % by SDS-PAGE
• Storage: Store at -80 centigrade; avoid multiple freeze-thaw cycles.

Gene Information

• Gene Name: UBE3A ubiquitin protein ligase E3A ( Homo sapiens )
• Official Symbol: UBE3A
• Synonyms: AS; ANCR; E6-AP; E6AP; HPVE6A; EPVE6AP
• Gene ID: 7337
• mRNA Refseq: NM_000462.3
• Protein Refseq: NP_000453
• MIM: 601623
• UniProt ID: Q05086