UGT1A1 Protein, UDP glucuronosyltransferase 1 family, polypeptide A1

UGT1A1

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UGT1A1

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A1
Background The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
Synonyms UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A1-1120H Recombinant Human UGT1A1 Protein, His-tagged E. coli His
    Human UGT1A1-18H Recombinant Human UGT1A1 Protein, His-tagged E.coli His
    Human UGT1A1-56H Recombinant Human UGT1A1 Protein, His-tagged Yeast His
    Human UGT1A1-1118H Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1 Human N/A
    Human UGT1A1-26H Recombinant Human UGT1A1, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A1-513HCL Recombinant Human UGT1A1 293 Cell Lysate HEK293 N/A
    Mouse UGT1A1-17804M Recombinant Mouse UGT1A1 Protein Mammalian Cell His
    Rhesus Macaque UGT1A1-5099R Recombinant Rhesus monkey UGT1A1 Protein, His-tagged Mammalian Cell His
    Zebrafish UGT1A1-3541Z Recombinant Zebrafish UGT1A1 Mammalian Cell His

    UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions ALDH1B1; CRYL1; AKR1B1L; UGT2A2; UGT1A1; UGT1A6; UGT1A6B; UGT2A1; UGT2A3; UGT1A7C
    Ascorbate and aldarate metabolism UGT2A1; UGT1A6A; UGT1A9; ALDH1B1; UGT1A2; UGT1AB; UGT1A7C; UGT5G1; ALDH9A1; RGN
    Steroid hormone biosynthesis CYP3A65; CYP2D26; CYP7A1A; UGT1A2; CYP11C1; HSD17B8; CYP19A1A; COMTB; CYP3A7-CYP3AP1; SULT2ST3
    Starch and sucrose metabolism TREH; AMY2A2; PGM1; UGDH; GPI1; ENPP1; AMY2A4; PYGMA; G6PCA.2; AGL
    Retinol metabolism CYP2C39; DHRS3B; CYP1A; DHRS9; CYP2A12; UGT1A6; CYP2B19; CYP2A4; SDR16C5B; ALDH1A2
    Porphyrin and chlorophyll metabolism UGT5G1; UGT1A2; UGT2A2; COX15; PPOX; HMBSA; UGT1A7; UGT1A3; ALAD; UGT1A6
    Metabolism of xenobiotics by cytochrome P UGT1A3; GSTT2; UGT1A6B; DHDH; UGT1A6A; GSTA3; UGT1AB; AKR7A3; MGST3; ALDH3A1
    Drug metabolism - cytochrome P UGT1A9; AOX4; FMO4; GSTP1; GSTA; UGT1A2; GSTT2B; MAOB; MGST1.1; GSTT1B
    Drug metabolism - other enzymes IMPDH2; GUSB; UCK2; TPMT; UGT1A7; PNAT3; UGT1A2; UGT1A1; ITPA; UGT1A4
    Metabolic pathways DHRS4L2; GK2; CRLS1; SLC33A1; PAFAH1B2; NAMPT; PNPO; CYP7A1A; GGPS1; FASN
    Chemical carcinogenesis UGT1A4; CYP2C54; SULT1A1; CYP1B1; ADH6; CYP2C19; AKR1C2; UGT1A6B; ADH2-1; UGT1A6

    UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding KIAA1967; LYN; ITGB3; RPA2; C2orf56; AKT1; CASP2; CD40; TMBIM6; THRB
    enzyme inhibitor activity CALU; ATPIF1A; WDTC1; ARRB1; TXNIP; UGT1A9; KIAA1967; OAZ2B; APOV1; DGKZ
    glucuronosyltransferase activity UGT5A5; UGT2B3; LARGE; UGT5A1; UGT1A6B; UGT5B4; UGT1B5; UGT5G1; UGT2B5; B3GNT1
    NOT glucuronosyltransferase activity UGT1A7; UGT1A4; UGT1A1; UGT1A3; UGT1A6; UGT1A9
    protein heterodimerization activity ARNT2; H2-Q10; PVALB; H3F3C; CLNS1A; NFYC; POLE3; OSTB; BTBD11; HIST1H2AM
    protein homodimerization activity NR4A2; TNNC1; GPD1; E2F8; S100A16; CEBPE; NADK2; GYS2; DNTTIP1; HELT
    retinoic acid binding UGT1A1; PTGDSB; CRABP2; CYP26A1; CRABP1; LRAT; UGT1A9; CYP26B1; CRABP1B; UGT1A7
    steroid binding Ar; PAQR7; HSD11B2; SERPINA6; NR3C2; ESRRA; PAQR7A; PAQR8; CYP21A2; HSD17B10

    UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.

    UGDH; q9wmx2-pro_0000037550

    Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
    Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).

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