ugt1a1
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  • Official Full Name
  • UDP glucuronosyltransferase 1 family, polypeptide A1
  • Background
  • The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin.
  • Synonyms
  • UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
Cat.#:UGT1A1-1120HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UGT1A1 Protein, His-tagged
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Cat.#:UGT1A1-18HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human UGT1A1 Protein, His-tagged
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Cat.#:UGT1A1-56HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human UGT1A1 Protein, His-tagged
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Cat.#:UGT1A1-1118HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1
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Cat.#:UGT1A1-26HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human UGT1A1, MYC/DDK-tagged
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Cat.#:UGT1A1-17804MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UGT1A1 Protein
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Cat.#:UGT1A1-5099RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey UGT1A1 Protein, His-tagged
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Cat.#:UGT1A1-3541ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UGT1A1
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Cat.#:UGT1A1-513HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UGT1A1 293 Cell Lysate
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Involved Pathway

UGT1A1 involved in several pathways and played different roles in them. We selected most pathways UGT1A1 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Pentose and glucuronate interconversions
Akr1b3; UGT1A9; UGT2B15; UGT1A3; UGP2A; UGT5G1; AKR1A1B; OXSR1; UGT1A1; AKR1A1A
Ascorbate and aldarate metabolism
UGDH; UGT1A7C; UGT1AB; UGT2A3; UGT2A2; ALDH1B1; UGT1A1; UGT1A2; GKUP; ALDH9A1A.1
Steroid hormone biosynthesis
UGT2A3; HSD3B4; HSD3B6; COMTB; CYP3A7-CYP3AP1; CYP2C70; UGT1AB; SRD5A1; CYP2C50; HSD17B8
Starch and sucrose metabolism
UGDH; UGT2B15; GANC; AGLA; PYGMA; PGM2; AMY2A4; AMY1B; UGT1A7; AMY2A
Retinol metabolism
CYP4A12A; UGT2A1; RPE65; BCMO1; CYP2C70; DHRS3; RDH8A; CYP2A12; AOX3L1; UGT1A9
Porphyrin and chlorophyll metabolism
ALAD; BLVRB; UGT2B15; HMBSA; HCCSA.1; CPOX; CP; ALAS2; HMOX2; HCCS
Metabolism of xenobiotics by cytochrome P
UGT1A7; GSTO1; GSTP2; CYP2F2; GSTA1; CBR1L; SULT2A1; GSTA; GSTM7; GSTM
Drug metabolism - cytochrome P
GSTA1; UGT1A1; GSTP2; UGT2A1; GSTT2B; UGT2A3; ALDH3B2; GSTT1B; MAOA; GSTT1
Drug metabolism - other enzymes
UCK2; UGT1A6B; TPMT; UMPS; Ces2e; UGT1A9; Ces2c; UGT2B7; UGT1A6A; CDA
Metabolic pathways
KYNU; CERS2A; NDUFB5; MAN1A1; COMTB; TPK1; MCCC2; HSD3B6; ACLY; TKT
Chemical carcinogenesis
PTGS2; CYP2C54; SULT1A3; CHRNA7; GSTM2; UGT2A2; GSTA3; ALDH3B2; ADH1A; CYP1A1

Protein Function

UGT1A1 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A1 itself. We selected most functions UGT1A1 had, and list some proteins which have the same functions with UGT1A1. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein KIAA1967; NLRP1; NR5A1; BCL10; HIST1H2AI; RPS2; UBE4B; HYAL2; LDB2; HIST1H2AG
Function enzyme inhibitor activity
Related Protein CALU; PDE6H; UGT1A9; PRPSAP1; TXNIP; GCHFR; PLN; ANGPTL3; ATPIF1; UGT1A7
Function glucuronosyltransferase activity
Related Protein UGT2B1; UGT1A9; UGT5A4; UGT5G2; UGT1AB; UGT2B15; UGT2A4; EXT2; UGT1B3; UGT5D1
Function NOT glucuronosyltransferase activity
Related Protein UGT1A7; UGT1A3; UGT1A1; UGT1A4; UGT1A9; UGT1A6
Function protein heterodimerization activity
Related Protein SLC51B; DDIT3; SMC1A; VOX; POLE4; CLCF1; THRA; SUPT5H; NKX2; ARNT
Function protein homodimerization activity
Related Protein VIL1; GIPC1; Bcl2a1b; SNX6; CIDEA; PTPRE; DMBX1; SLC51A; CADM1B; TPD52L2
Function retinoic acid binding
Related Protein LCN12; CYP26A1; CYP26B1; CRABP2; CRABP2B; PTGDSB; NR2F2; UGT1A2; UGT1A1; LRAT
Function steroid binding
Related Protein HSD11B2; SERPINA6; PAQR8; FAM84B; NR3C2; PDIA2; ESRRB; ESRRGA; NR3C1; GPR30

Interacting Protein

UGT1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A1.
UGDH; q9wmx2-pro_0000037550

UGT1A1 Related Articles

Muhsain, SNF; Lang, MA; et al. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. TOXICOLOGY AND APPLIED PHARMACOLOGY 282:77-89(2015).
Lech, G; Slotwinski, R; et al. The role of tumour markers and biomarkers in colorectal cancer. NEOPLASMA 61:1-8(2014).