"UGT1A1" Related Products

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Recombinant Human UGT1A1 Protein, His-tagged

Cat.No.: UGT1A1-18H
Product Overview: Recombinant human uGT1A1(26-490aa), fused with His-tag at N-terminus, was expressed in E.coli.
Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
Source: E.coli
Species: Human
Tag : His
Form: Liquid
Molecular Mass: 54.7kDa (488aa)
AA Sequence: MGSSHHHHHHSSGLVPRGSHMGSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLD
Purity: > 90% by SDS - PAGE
Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use
Stability: Avoid repeated freezing and thawing cycles.
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade.
Concentration: 1mg/ml (determined by Bradford assay)
Storage Buffer: In 20mM Tris-HCl (pH8.0) containing 10% glycerol
Gene Name: UGT1A1
Official Symbol: UGT1A1 UDP glucuronosyltransferase family 1 member A1 [ Homo sapiens (human) ]
Synonyms: UGT1A1; UDP glucuronosyltransferase family 1 member A1; GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; UDP-glucuronosyltransferase 1-1; UDP glucuronosyltransferase 1 family, polypeptide A1; UDP glycosyltransferase 1 family, polypeptide A1; UDP-glucuronosyltransferase 1-A; DP-glucuronosyltransferase 1A1; UGT-1A; UGT1*1; UGT1-01; UGT1.1; bilirubin UDP-glucuronosyltranserase; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; bilirubin-specific UDPGT isozyme 1; EC 2.4.1.17
Gene ID: 54658
mRNA Refseq: NM_000463
Protein Refseq: NP_000454
MIM: 191740
UniProt ID: P22309

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