| Description : |
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. |
| Source : |
E.coli |
| Species : |
Human |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
54.7kDa (488aa) |
| AA Sequence : |
MGSSHHHHHHSSGLVPRGSHMGSHA GKILLIPVDGSHWLSMLGAIQQLQQ RGHEIVVLAPDASLYIRDGAFYTLK TYPVPFQREDVKESFVSLGHNVFEN DSFLQRVIKTYKKIKKDSAMLLSGC SHLLHNKELMASLAESSFDVMLTDP FLPCSPIVAQYLSLPTVFFLHALPC SLEFEATQCPNPFSYVPRPLSSHSD HMTFLQRVKNMLIAFSQNFLCDVVY SPYATLASEFLQREVTVQDLLSSAS VWLFRSDFVKDYPRPIMPNMVFVGG INCLHQNPLSQEFEAYINASGEHGI VVFSLGSMVSEIPEKKAMAIADALG KIPQTVLWRYTGTRPSNLANNTILV KWLPQNDLLGHPMTRAFITHAGSHG VYESICNGVPMVMMPLFGDQMDNAK RMETKGAGVTLNVLEMTSEDLENAL KAVINDKSYKENIMRLSSLHKDRPV EPLDLAVFWVEFVMRHKGAPHLRPA AHDLTWYQYHSLD |
| Purity : |
> 90% by SDS - PAGE |
| Notes : |
For research use only. This product is not intended or approved for human, diagnostics or veterinary use |
| Stability : |
Avoid repeated freezing and thawing cycles. |
| Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. |
| Concentration : |
1mg/ml (determined by Bradford assay) |
| Storage Buffer : |
In 20mM Tris-HCl (pH8.0) containing 10% glycerol |
