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Active Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1

Cat.No. : UGT1A1-1118H
Product Overview : Human UGT1A1 (NP_000454, 1 a.a. ~ 154 a.a.) partial recombinant protein expressed in Escheri- chia coli.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : UGT1A1-1118H
Description : UGT-1A is a uridine diphosphate glucuronyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small li- pophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
Sequence : MATKAVCVLKGDGPVQG IINFEQKESNGPVKVWGS IKGLTEGLHGFHVHEFGD NTAGCTSGPHFNPLSRKH GGPKDEERHVGDLGNVTA DKDGVADVSIEDSVISLSGD HCIIGRTLVVHEKADDLGKGGN EESTKTGNAGSRLACGVIGIAQ
Theoretical MW (kDa) : 15.9
Form : Liquid
Preparation Method : Escherichia coli expression system
Purity : μ 95% by SDS-PAGE
Activity : Specific activity is > 90 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.8 at 25°C in a 1.5 ml reaction volume.
Application : SDS-PAGE; Functional Study
Storage Buffer : In 20 mM Tris, pH 7.5 (10% glycerol)
Storage : Store at 4°C for 1~2 weeks. For long term storage store at -20°C or -80°C.Aliquot to avoid repeated freezing and thawing.
Unitprot ID : Q5DT03
Pathways : Ascorbate and aldarate metabolism; Biological oxidants; Drug metabolish-cytochrome P450; Estrogen metabolish; Irinotecan pathway; Metabolish of lipids and lipoproteins; Retinol metabolish; Starch and sucrose metabolish; Steroid hormone biosynthesis; metabolish pathway
Functions : enzyme binding; enzyme inhibitor activity; qlucuronosyltransfersase activity; protein heterodimerization activity; retinoic acid binding; steroid binding
Gene Name : UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens ]
Official Symbol : UGT1A1
Synonyms : UGT1A1; GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; HUG-BR1; UDP glycosyltransferase 1 family, polypeptide A1; UGT1-01; UGT-1A; UGT1*1; UGT1.1; UDP-glucuronosyltransfersae 1-A1; UDPGT 1-1; EC 2.4.1.17; BILIQTL1; Hug-br1; UDP glucuronosyltransferase 1 family, polypeptide A1;Bilirubin-specific UDPGT isozyme 1; UDPGT; UDP-glucuronosyltransfersae 1-A; OTTHUMP000000651199
Gene ID : 54658
mRNA Refseq : NM_000463
Protein Refseq : NP_000454
MIM : 191740
Chromosome Location : 2q37

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What is the function of UGT1A1? 07/14/2022

UGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.

What is the relationship between bilirubin and UGT1A1? 01/24/2022

Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.

What diseases is UGT1A1 involved in? 11/23/2021

UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.

Where is UGT1A1 mainly expressed? 03/11/2021

UGT1A1 is mainly expressed in the liver.

What are the effects of mutations in the UGT1A1 gene? 02/09/2021

Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.

Customer Reviews (2)

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08/12/2022

    The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

    05/14/2022

      Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.

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