Active Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1
Cat.No. : | UGT1A1-1118H |
Product Overview : | Human UGT1A1 (NP_000454, 1 a.a. ~ 154 a.a.) partial recombinant protein expressed in Escheri- chia coli. |
- Specification
- Gene Information
- Related Products
Cat. No. : | UGT1A1-1118H |
Description : | UGT-1A is a uridine diphosphate glucuronyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small li- pophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. |
Sequence : | MATKAVCVLKGDGPVQG IINFEQKESNGPVKVWGS IKGLTEGLHGFHVHEFGD NTAGCTSGPHFNPLSRKH GGPKDEERHVGDLGNVTA DKDGVADVSIEDSVISLSGD HCIIGRTLVVHEKADDLGKGGN EESTKTGNAGSRLACGVIGIAQ |
Theoretical MW (kDa) : | 15.9 |
Form : | Liquid |
Preparation Method : | Escherichia coli expression system |
Purity : | μ 95% by SDS-PAGE |
Activity : | Specific activity is > 90 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.8 at 25°C in a 1.5 ml reaction volume. |
Application : | SDS-PAGE; Functional Study |
Storage Buffer : | In 20 mM Tris, pH 7.5 (10% glycerol) |
Storage : | Store at 4°C for 1~2 weeks. For long term storage store at -20°C or -80°C.Aliquot to avoid repeated freezing and thawing. |
Unitprot ID : | Q5DT03 |
Pathways : | Ascorbate and aldarate metabolism; Biological oxidants; Drug metabolish-cytochrome P450; Estrogen metabolish; Irinotecan pathway; Metabolish of lipids and lipoproteins; Retinol metabolish; Starch and sucrose metabolish; Steroid hormone biosynthesis; metabolish pathway |
Functions : | enzyme binding; enzyme inhibitor activity; qlucuronosyltransfersase activity; protein heterodimerization activity; retinoic acid binding; steroid binding |
Gene Name : | UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens ] |
Official Symbol : | UGT1A1 |
Synonyms : | UGT1A1; GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; HUG-BR1; UDP glycosyltransferase 1 family, polypeptide A1; UGT1-01; UGT-1A; UGT1*1; UGT1.1; UDP-glucuronosyltransfersae 1-A1; UDPGT 1-1; EC 2.4.1.17; BILIQTL1; Hug-br1; UDP glucuronosyltransferase 1 family, polypeptide A1;Bilirubin-specific UDPGT isozyme 1; UDPGT; UDP-glucuronosyltransfersae 1-A; OTTHUMP000000651199 |
Gene ID : | 54658 |
mRNA Refseq : | NM_000463 |
Protein Refseq : | NP_000454 |
MIM : | 191740 |
Chromosome Location : | 2q37 |
Products Types
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UGT1A1-9885M | Recombinant Mouse UGT1A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
UGT1A1-513HCL | Recombinant Human UGT1A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionUGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.
Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.
UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.
UGT1A1 is mainly expressed in the liver.
Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.
Customer Reviews (2)
Write a reviewThe product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.
Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.
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