Recombinant Human UGT1A1 Protein, His-tagged

• Cat.No.: UGT1A1-1120H
• Product Overview: Recombinant Human UGT1A1 Protein (His26~Gly276 (Accession # P22309)) was expressed in E. coli with N-terminal His tag.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Molecular Mass: 32.0kDa
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: > 97%
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Protein length: His26-Gly276

Gene Information

• Gene Name: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens ]
• Official Symbol: UGT1A1
• Synonyms: UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1
• Gene ID: 54658
• mRNA Refseq: NM_000463
• Protein Refseq: NP_000454
• MIM: 191740
• UniProt ID: P22309

Reviews

08/12/2022

The product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.

05/14/2022

Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.

Q&As

What is the function of UGT1A1?

UGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.

What is the relationship between bilirubin and UGT1A1?

Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.

What diseases is UGT1A1 involved in?

UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.

Where is UGT1A1 mainly expressed?

UGT1A1 is mainly expressed in the liver.

What are the effects of mutations in the UGT1A1 gene?

Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.