Recombinant Human UGT1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | UGT1A1-1019H |
Product Overview : | UGT1A1 MS Standard C13 and N15-labeled recombinant protein (NP_000454) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Description : | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc&DDK |
Molecular Mass : | 59.6 kDa |
AA Sequence : | MAVESQGGRPLVLGLLLCVLGPVVS HAGKILLIPVDGSHWLSMLGAIQQL QQRGHEIVVLAPDASLYIRDGAFYT LKTYPVPFQREDVKESFVSLGHNVF ENDSFLQRVIKTYKKIKKDSAMLLS GCSHLLHNKELMASLAESSFDVMLT DPFLPCSPIVAQYLSLPTVFFLHAL PCSLEFEATQCPNPFSYVPRPLSSH SDHMTFLQRVKNMLIAFSQNFLCDV VYSPYATLASEFLQREVTVQDLLSS ASVWLFRSDFVKDYPRPIMPNMVFV GGINCLHQNPLSQEFEAYINASGEH GIVVFSLGSMVSEIPEKKAMAIADA LGKIPQTVLWRYTGTRPSNLANNTI LVKWLPQNDLLGHPMTRAFITHAGS HGVYESICNGVPMVMMPLFGDQMDN AKRMETKGAGVTLNVLEMTSEDLEN ALKAVINDKSYKENIMRLSSLHKDR PVEPLDLAVFWVEFVMRHKGAPHLR PAAHDLTWYQYHSLDVIGFLLAVVL TVAFITFKCCAYGYRKCLGKKGRVK KAHKSKTHTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | UGT1A1 UDP glucuronosyltransferase family 1 member A1 [ Homo sapiens (human) ] |
Official Symbol : | UGT1A1 |
Synonyms : | UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1, UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1; |
Gene ID : | 54658 |
mRNA Refseq : | NM_000463 |
Protein Refseq : | NP_000454 |
MIM : | 191740 |
UniProt ID : | P22309 |
Products Types
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◆ Lysates | ||
UGT1A1-513HCL | Recombinant Human UGT1A1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (2)
Write a reviewThe product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.
Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.
Q&As (5)
Ask a questionUGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.
Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.
UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.
UGT1A1 is mainly expressed in the liver.
Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.
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