Recombinant Human UGT1A1 293 Cell Lysate
Cat.No. : | UGT1A1-513HCL |
- Specification
- Gene Information
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Description : | Antigen standard for UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens ] |
Official Symbol : | UGT1A1 |
Synonyms : | UGT1A1; UDP glucuronosyltransferase 1 family, polypeptide A1; GNT1, UDP glycosyltransferase 1 family, polypeptide A1 , UGT1; UDP-glucuronosyltransferase 1-1; UGT1A; UGT-1A; UGT1*1; UGT1.1; UGT1-01; UDP-glucuronosyltransferase 1-A; UDP-glucuronosyltransferase 1A1; bilirubin-specific UDPGT isozyme 1; bilirubin UDP-glucuronosyltransferase 1-1; bilirubin UDP-glucuronosyltransferase isozyme 1; UDP glycosyltransferase 1 family, polypeptide A1; GNT1; UGT1; UDPGT; HUG-BR1; BILIQTL1; UDPGT 1-1; |
Gene ID : | 54658 |
mRNA Refseq : | NM_000463 |
Protein Refseq : | NP_000454 |
MIM : | 191740 |
UniProt ID : | P22309 |
Chromosome Location : | 2q37 |
Pathway : | Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Ascorbate biosynthesis, animals, glucose-1P =>ascorbate, organism-specific biosystem; Ascorbate biosynthesis, animals, glucose-1P => ascorbate, conserved biosystem; Biological oxidations, organism-specific biosystem; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionUGT1A1 converts lipophilic small molecules, such as drugs, into water-soluble and excretable metabolites.
Bilirubin is a binding substrate for UGT1A1 and UGT1A1 is involved in bilirubin metabolism.
UGT1A1 is involved in lung cancer, colorectal cancer and hyperbilirubinemia, among other diseases.
UGT1A1 is mainly expressed in the liver.
Mutations in the UGT1A1 gene prevent the glucuronidation of free bilirubin and reduces bilirubin metabolism and increases serum free bilirubin levels.
Customer Reviews (2)
Write a reviewThe product was kept in perfect condition and delivered on time so that I got the perfect product in the shortest time possible.
Customer service contacted me in a timely manner and helped me solve a lot of problems that arose in my experiments.
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