usp2
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  • Official Full Name
  • ubiquitin specific peptidase 2
  • Background
  • This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Synonyms
  • USP2; ubiquitin specific peptidase 2; USP9; UBP41; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2;
Cat.#:USP2-1042HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP2
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Cat.#:USP2-153HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP2, His-tagged
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Cat.#:USP2-182HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP2, GST-tagged
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Cat.#:USP2-320HTag:FLAG
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human USP2 protein, FLAG-tagged
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Cat.#:USP2-3620HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP2, GST-tagged
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Cat.#:USP2-544HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human USP2 Protein, His-tagged
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Cat.#:Usp2-106MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Usp2 Protein, His-tagged
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Cat.#:USP2-17909MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse USP2 Protein
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Cat.#:USP2-6473RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat USP2 Protein
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Cat.#:Usp2-694RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Usp2 protein
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Cat.#:USP2-5124RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey USP2 Protein, His-tagged
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Cat.#:USP2-6487CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken USP2
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Cat.#:USP2-468HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human USP2 293 Cell Lysate
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Involved Pathway

USP2 involved in several pathways and played different roles in them. We selected most pathways USP2 participated on our site, such as Death Receptor Signalling, Regulation of TNFR1 signaling, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Death Receptor Signalling
OTULIN; CYLD; TAB1; TAX1BP1; TAX1BP1B; RNF31; OTUD7B; RBCK1; OTULINB; FAM105B
Regulation of TNFR1 signaling
CLIP3; USP4; OTULINB; RBCK1; OTULIN; SHRPRBCK1R; FAM105B; TAX1BP1; OTUD7B; TAX1BP1B
Signal Transduction
APOM; CRABP2A; KREMEN2; RGS10; TRH; FGD4A; RGS21; SHARPIN; RCA2.1; RGR
TNF signaling
TAX1BP1; RNF31; USP2; OTULINB; SHARPIN; SHRPRBCK1R; TAX1BP1B; FAM105B; CLIP3; RBCK1
TNF-alpha/NF-kB Signaling Pathway
DPF2; TNIP1; MCC; AKAP8; KIAA1967; UNC5CL; SMARCE1; KPNA6; PPP1R13L; LRPPRC
TNFR1-induced NFkappaB signaling pathway
USP4; OTUD7B; SHARPIN; RNF31; SHRPRBCK1R; USP2
TNFR1-induced proapoptotic signaling
USP4; OTUD7B; USP2

Protein Function

USP2 has several biochemical functions, for example, cyclin binding, cysteine-type endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP2 itself. We selected most functions USP2 had, and list some proteins which have the same functions with USP2. You can find most of the proteins on our site.
Function
Related Protein
Function cyclin binding
Related Protein FBXW7; PTCH1; PFTK1; HDAC3; INCA1; CDK14; USP2; CDK13; CDK12; CDK6
Function cysteine-type endopeptidase activity
Related Protein USP47; CTS7; CTSK; ESPL1; USP45; CTSF; USP50; CTSJ; CASP2; USP9X
Function identical protein binding
Related Protein ANXA4; ABCD1; AXIN1; RYR2; SAFB2; LCK; CAV1; ROBO2; G6PD; USP2
Function metal ion binding
Related Protein COL1A2; SOBPA; MINA; HIVEP2A; PRDM12B; OTUD7A; ZFP507; ROCK2B; CYP4A10; PMELA
Function protein binding
Related Protein PEX10; GLS; RGMA; KIAA1967; FOXR2; ZNF593; TBX5; ZEB1; CLDN8; C9orf43
Function ubiquitin protein ligase binding
Related Protein PPARGC1A; HSPA5; NKD2; DLG3; GGN; SMAD2; SMC6; TMEM189; TRIB3; CHEK2
Function ubiquitin-specific protease activity
Related Protein USP17L5; OTUB1; ATXN3; OTUD5A; OTUD7A; CYLD; USP9; OTUD6A; USP33; USP50

Interacting Protein

USP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP2.
KRT15; TRAF2; HOMER3; NEFL; TRIM27; GOLGA2

USP2 Related Articles

Stes, E; Laga, M; et al. A COFRADIC Protocol To Study Protein Ubiquitination. JOURNAL OF PROTEOME RESEARCH 13:3107-3113(2014).
Husted, RF; Lu, HY; et al. Oxygen regulation of the epithelial Na channel in the collecting duct. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 300:F412-F424(2011).