WEE1 Protein, WEE1 homolog


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Official Full Name WEE1 homolog
Background Entry of all eukaryotic cells into mitosis is regulated by activation of cdc2 kinase. The critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Thr14 (1,2). Phosphorylation at Tyr15 and Th
Synonyms WEE1; WEE1 homolog (S. pombe); wee1+ (S. pombe) homolog; wee1-like protein kinase; wee1A kinase; WEE1+ homolog; WEE1A; WEE1hu; FLJ16446; DKFZp686I18166
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Insect cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WEE1-001H Recombinant Human WEE1 Protein, GST-tagged E. coli GST
    Human WEE1-707H Recombinant Human WEE1 Protein, GST-HIS6-tagged Insect cell GST/His
    Human WEE1-1930HCL Recombinant Human WEE1 cell lysate N/A
    Human WEE1-36H Recombinant Human WEE1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human WEE1-3726H Recombinant Human WEE1, GST-tagged E.coli GST
    Mouse WEE1-18521M Recombinant Mouse WEE1 Protein Mammalian Cell His
    Rat Wee1-32R Recombinant Rat Wee1 protein, GST-tagged, active E.coli GST
    Rat WEE1-6584R Recombinant Rat WEE1 Protein Mammalian Cell His
    Chicken WEE1-2848C Recombinant Chicken WEE1 Mammalian Cell His
    Zebrafish WEE1-1445Z Recombinant Zebrafish WEE1 Mammalian Cell His

    WEE1 involved in several pathways and played different roles in them. We selected most pathways WEE1 participated on our site, such as Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with WEE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle TUBG1; SMAD3A; CDH1-A; ARF1; TTK; HDAC5; PLK1; MCM10; TFDP2; OIP5

    WEE1 has several biochemical functions, for example, ATP binding, magnesium ion binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WEE1 itself. We selected most functions WEE1 had, and list some proteins which have the same functions with WEE1. You can find most of the proteins on our site.

    Function Related Protein
    magnesium ion binding THTPA; NUAK2; AASDHPPT; STK36; PTENA; ATP9B; PPM1B; ATP8B3; STK4; IDH3B
    non-membrane spanning protein tyrosine kinase activity CLK1; MELK; ZAP70; EIF2AK2; WEE2; JAK3; JAK2; HCK; PTK2BB; FYNA
    protein binding MMP15; APOH; LPA; NCOR1; KPNA1; FAF2; ATG3; MPZL1L; GNL3; ATP6AP2
    protein tyrosine kinase activity MAP2K2; BCR; PTK2BB; KDR; IGF1RA; AXL; PTK2; JAK2B; MAP3K11; EPHA4B

    WEE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WEE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WEE1.

    YWHAB; FBXW11; YWHAZ; BTRC; N/A; PLK1; Cdk1; SFN; YWHAG; NEK6; czc8004

    Schmid, BC; Oehler, MK; et al. New perspectives in ovarian cancer treatment. MATURITAS 77:128-136(2014).
    Lehmann, BD; Pietenpol, JA; et al. Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. JOURNAL OF PATHOLOGY 232:142-150(2014).

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